Journal ArticleDOI
The 2001 Bethesda System: terminology for reporting results of cervical cytology.
Diane Solomon,Diane D. Davey,Robert J. Kurman,Marianne U. Prey,Stephen S. Raab,Mark E. Sherman,David C. Wilbur,Nancy A. Young +7 more
TLDR
The 2001 Bethesda System terminology reflects important advances in biological understanding of cervical neoplasia and cervical screening technology.Abstract:
ObjectivesThe Bethesda 2001 Workshop was convened to evaluate and update the 1991
Bethesda System terminology for reporting the results of cervical cytology.
A primary objective was to develop a new approach to broaden participation
in the consensus process.ParticipantsForum groups composed of 6 to 10 individuals were responsible for developing
recommendations for discussion at the workshop. Each forum group included
at least 1 cytopathologist, cytotechnologist, clinician, and international
representative to ensure a broad range of views and interests. More than 400
cytopathologists, cytotechnologists, histopathologists, family practitioners,
gynecologists, public health physicians, epidemiologists, patient advocates,
and attorneys participated in the workshop, which was convened by the National
Cancer Institute and cosponsored by 44 professional societies. More than 20
countries were represented.EvidenceLiterature review, expert opinion, and input from an Internet bulletin
board were all considered in developing recommendations. The strength of evidence
of the scientific data was considered of paramount importance.Consensus ProcessBethesda 2001 was a year-long iterative review process. An Internet
bulletin board was used for discussion of issues and drafts of recommendations.
More than 1000 comments were posted to the bulletin board over the course
of 6 months. The Bethesda Workshop, held April 30-May 2, 2001, was open to
the public. Postworkshop recommendations were posted on the bulletin board
for a last round of critical review prior to finalizing the terminology.ConclusionsBethesda 2001 was developed with broad participation in the consensus
process. The 2001 Bethesda System terminology reflects important advances
in biological understanding of cervical neoplasia and cervical screening technology.read more
Citations
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Journal ArticleDOI
Clinical significance of atypical glandular cells by the 2001 Bethesda System in cytohistologic correlation.
TL;DR: A diagnosis of AGC is more clinically significant by the 2001 Bethesda System, especially the "AGC, favor neoplastic" category, and some characteristic background cytologic findings were noticed in most cases of endometrial, fallopian tube and endocervical adenocarcinoma.
Journal ArticleDOI
Neoplasia intra-epitelial cervical: diagnóstico e tratamento
TL;DR: Several aspects of cervical cancer screening and its viable treatment are reviewed, including the type of viral infection, severity of the cervical intraepithelial neoplasia and its histological type.
Journal ArticleDOI
Genomic amplification of the human telomerase RNA gene for differential diagnosis of cervical disorders
Zheng Tu,Aipeng Zhang,Ruifang Wu,Jing Jiang,Yali Li,Na Wulan,Jingran Li,Yongmei Zhang,Yi-bing Li,Zhong Chen,Lihui Wei +10 more
TL;DR: FISH detection of TERC amplification may provide an effective, noninvasive approach in conjunction with cytopathologic or histopathologic evaluation for differential diagnosis of low- and high-grade cervical disorders.
Journal ArticleDOI
High prevalence of hpv multiple genotypes in women with persistent chlamydia trachomatis infection
Silva Seraceni,Francesco De Seta,Claudia Colli,Rossella Del Savio,Giuliano Pesel,Valentina Zanin,Pierlanfranco D'Agaro,Carlo Contini,Manola Comar +8 more
TL;DR: A high prevalence of HPV multiple infections have been found in young women affected with a C. trachomatis chronic infection and the expression of CHSP60-1, interfering with both apoptotic and cellular senescence pathways, may promote a favourable local microenvironment for HPV infection.
Journal ArticleDOI
DNA Ploidy Cytometry Testing for Cervical Cancer Screening in China (DNACIC Trial): a Prospective Randomized, Controlled Trial
Hua Tong,Rong Shen,Wang Zhuming,YanJing Kan,Yiquan Wang,FengShan Li,Fuzhou Wang,Jie Yang,XiRong Guo +8 more
TL;DR: The results highlight the benefit of the DNA cytometry testing strategy in mass cervical cancer screening with greater sensitivity and positive predicted value than the conventional cytologic testing in developing settings.
References
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TL;DR: The incidence of HPV infection in sexually active young college women is high and the short duration of most HPV infections in these women suggests that the associated cervical dysplasia should be managed conservatively.
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Papillomaviruses Causing Cancer: Evasion From Host-Cell Control in Early Events in Carcinogenesis
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Journal ArticleDOI
2001 Consensus Guidelines for the Management of Women With Cervical Cytological Abnormalities
TL;DR: Management of women with atypical squamous cells (ASC) depends on whether the Papanicolaou test is subcategorized as of undetermined significance (ASC-US) or as cannot exclude high-grade squamous intraepithelial lesion (HSIL) (asc-H).
Journal ArticleDOI
Comparison of Three Management Strategies for Patients With Atypical Squamous Cells of Undetermined Significance: Baseline Results From a Randomized Trial
TL;DR: HC 2 testing for cancer-associated HPV DNA is a viable option in the management of women with ASCUS and has greater sensitivity to detect CIN3 or above and specificity comparable to a single additional cytologic test indicating ASCUS or above.