Journal ArticleDOI
The 2001 Bethesda System: terminology for reporting results of cervical cytology.
Diane Solomon,Diane D. Davey,Robert J. Kurman,Marianne U. Prey,Stephen S. Raab,Mark E. Sherman,David C. Wilbur,Nancy A. Young +7 more
TLDR
The 2001 Bethesda System terminology reflects important advances in biological understanding of cervical neoplasia and cervical screening technology.Abstract:
ObjectivesThe Bethesda 2001 Workshop was convened to evaluate and update the 1991
Bethesda System terminology for reporting the results of cervical cytology.
A primary objective was to develop a new approach to broaden participation
in the consensus process.ParticipantsForum groups composed of 6 to 10 individuals were responsible for developing
recommendations for discussion at the workshop. Each forum group included
at least 1 cytopathologist, cytotechnologist, clinician, and international
representative to ensure a broad range of views and interests. More than 400
cytopathologists, cytotechnologists, histopathologists, family practitioners,
gynecologists, public health physicians, epidemiologists, patient advocates,
and attorneys participated in the workshop, which was convened by the National
Cancer Institute and cosponsored by 44 professional societies. More than 20
countries were represented.EvidenceLiterature review, expert opinion, and input from an Internet bulletin
board were all considered in developing recommendations. The strength of evidence
of the scientific data was considered of paramount importance.Consensus ProcessBethesda 2001 was a year-long iterative review process. An Internet
bulletin board was used for discussion of issues and drafts of recommendations.
More than 1000 comments were posted to the bulletin board over the course
of 6 months. The Bethesda Workshop, held April 30-May 2, 2001, was open to
the public. Postworkshop recommendations were posted on the bulletin board
for a last round of critical review prior to finalizing the terminology.ConclusionsBethesda 2001 was developed with broad participation in the consensus
process. The 2001 Bethesda System terminology reflects important advances
in biological understanding of cervical neoplasia and cervical screening technology.read more
Citations
More filters
Journal ArticleDOI
The Bethesda System 2001 recommendation for reporting of benign appearing endometrial cells in Pap tests of women age 40 years and older leads to unwarranted surveillance when followed without clinical qualifiers
TL;DR: The Bethesda System 2001 led to increased reporting of BEC only in premenopausal women, leading to biopsies performed solely for BEC in these women with no pathology detected, and immediate biopsy is a valid consideration.
Journal ArticleDOI
The Role of Polymerase Chain Reaction of High-Risk Human Papilloma Virus in the Screening of High-Grade Squamous Intraepithelial Lesions in the Anal Mucosa of Human Immunodeficiency Virus-Positive Males Having Sex with Males
Carmen Hidalgo-Tenorio,Mar Rivero-Rodriguez,Concepción Gil-Anguita,Javier Esquivias,Rodrigo López-Castro,Jessica Ramírez-Taboada,Mercedes Lopez De Hierro,Miguel A. López-Ruiz,R. Javier Martínez,Juan P. Llaño +9 more
TL;DR: When cytology and PCR HR-HPV findings are normal, the diagnosis of pre-malignant HSIL can be reliably ruled-out in HIV-positive patients.
Journal ArticleDOI
prevalence of Anal Cytologic Abnormalities in a French Referral Population: A Prospective Study with Special Emphasis on Hiv, Hpv, and Smoking
Isabelle Etienney,Sarra Vuong,Fady Daniel,Benoit Mory,Milad Taouk,S. Sultan,Christian Thomas,Josée Bourguignon,Vincent de Parades,Nathalie Meary,André Balaton,Patrick Atienza,Pierre Bauer +12 more
TL;DR: In this paper, the frequency of low-grade squamous intraepithelial lesion is raised in HIV seropositive males and also where there is a history of condyloma, which corroborates the necessity for regular monitoring and screening of these patients at risk.
Journal ArticleDOI
Which test is a better strategy to determine the outcome of atypical glandular cell-categorized Pap smears? Immunocytochemical p16INK4A expression or human papillomavirus test--a retrospective cohort study.
TL;DR: Pathogenic activity of HR-HPV was indicated by p16 expression on smears and tissue sections, which appears to be a better strategy than HR- HPV viral load test for the detection of clinically insignificant lesions from AGC-categorized Pap smears.
Journal ArticleDOI
Prevalence and distribution of cervical high-risk human papillomavirus and cytological abnormalities in women living with HIV in Denmark: the SHADE
Kristina Thorsteinsson,Kristina Thorsteinsson,Merete Storgaard,Terese L. Katzenstein,Terese L. Katzenstein,Steen Ladelund,Frederikke Falkencrone Rönsholt,Isik Somuncu Johansen,Gitte Pedersen,Lailoma Hashemi,Lars Nørregård Nielsen,Lisbeth Nilas,Lisbeth Nilas,Niels Obel,Niels Obel,Jesper Bonde,Anne-Mette Lebech,Anne-Mette Lebech +17 more
TL;DR: Cervical hrHPV and cytological abnormalities were predicted by short duration of HAART, and WLWH presented with more cervical HRHPV infections and cytology abnormalities, and a different distribution of hrHPVs genotypes compared with WGP.
References
More filters
Journal ArticleDOI
Natural history of cervicovaginal papillomavirus infection in young women
TL;DR: An increased risk of HPV infection was significantly associated with younger age, Hispanic ethnicity, black race, an increased number of vaginal-sex partners, high frequencies of vaginal sex and alcohol consumption, anal sex, and certain characteristics of partners.
Journal ArticleDOI
Natural History of Cervicovaginal Papillomavirus Infection in Young Women Gyf Ho
TL;DR: The incidence of HPV infection in sexually active young college women is high and the short duration of most HPV infections in these women suggests that the associated cervical dysplasia should be managed conservatively.
Journal ArticleDOI
Papillomaviruses Causing Cancer: Evasion From Host-Cell Control in Early Events in Carcinogenesis
TL;DR: Modifications in host-cell genes, most likely engaged in the control of HPV gene expression in proliferating cells, emerge as important events in HPV-mediated carcinogenesis.
Journal ArticleDOI
2001 Consensus Guidelines for the Management of Women With Cervical Cytological Abnormalities
TL;DR: Management of women with atypical squamous cells (ASC) depends on whether the Papanicolaou test is subcategorized as of undetermined significance (ASC-US) or as cannot exclude high-grade squamous intraepithelial lesion (HSIL) (asc-H).
Journal ArticleDOI
Comparison of Three Management Strategies for Patients With Atypical Squamous Cells of Undetermined Significance: Baseline Results From a Randomized Trial
TL;DR: HC 2 testing for cancer-associated HPV DNA is a viable option in the management of women with ASCUS and has greater sensitivity to detect CIN3 or above and specificity comparable to a single additional cytologic test indicating ASCUS or above.