Journal ArticleDOI
The 2001 Bethesda System: terminology for reporting results of cervical cytology.
Diane Solomon,Diane D. Davey,Robert J. Kurman,Marianne U. Prey,Stephen S. Raab,Mark E. Sherman,David C. Wilbur,Nancy A. Young +7 more
TLDR
The 2001 Bethesda System terminology reflects important advances in biological understanding of cervical neoplasia and cervical screening technology.Abstract:
ObjectivesThe Bethesda 2001 Workshop was convened to evaluate and update the 1991
Bethesda System terminology for reporting the results of cervical cytology.
A primary objective was to develop a new approach to broaden participation
in the consensus process.ParticipantsForum groups composed of 6 to 10 individuals were responsible for developing
recommendations for discussion at the workshop. Each forum group included
at least 1 cytopathologist, cytotechnologist, clinician, and international
representative to ensure a broad range of views and interests. More than 400
cytopathologists, cytotechnologists, histopathologists, family practitioners,
gynecologists, public health physicians, epidemiologists, patient advocates,
and attorneys participated in the workshop, which was convened by the National
Cancer Institute and cosponsored by 44 professional societies. More than 20
countries were represented.EvidenceLiterature review, expert opinion, and input from an Internet bulletin
board were all considered in developing recommendations. The strength of evidence
of the scientific data was considered of paramount importance.Consensus ProcessBethesda 2001 was a year-long iterative review process. An Internet
bulletin board was used for discussion of issues and drafts of recommendations.
More than 1000 comments were posted to the bulletin board over the course
of 6 months. The Bethesda Workshop, held April 30-May 2, 2001, was open to
the public. Postworkshop recommendations were posted on the bulletin board
for a last round of critical review prior to finalizing the terminology.ConclusionsBethesda 2001 was developed with broad participation in the consensus
process. The 2001 Bethesda System terminology reflects important advances
in biological understanding of cervical neoplasia and cervical screening technology.read more
Citations
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Journal ArticleDOI
Predictors of persistent cytologic abnormalities after treatment of cervical intraepithelial neoplasia in Soweto, South Africa: a cohort study in a HIV high prevalence population
Yasmin Adam,Yasmin Adam,Cyril J. Van Gelderen,Cyril J. Van Gelderen,Guy de Bruyn,James McIntyre,Diane A Turton,Diane A Turton,Neil A. Martinson,Neil A. Martinson +9 more
TL;DR: extremely high risk of cytological abnormality at follow-up after treatment more so in patients with incomplete excision and in the presence of immunocompromise is shown.
Journal ArticleDOI
Effect of HIV Infection on Atypical Squamous Cells of Undetermined Significance
Ann Duerr,Pangaja Paramsothy,Denise J. Jamieson,Charles M. Heilig,Robyn S. Klein,Susan Cu-Uvin,Paula Schuman,Jean Anderson +7 more
TL;DR: Higher risk of SIL following the appearance of ASCUS among HIV-infected women, especially women with low CD4+ lymphocyte counts, supports the need for follow up with colposcopy and histologic examination, as indicated, to allow early detection and treatment of SIL.
Journal ArticleDOI
Aberrant gene-specific DNA methylation signature analysis in cervical cancer.
Samatha Bhat,Shama Prasada Kabekkodu,Vinay Koshy Varghese,Sanjiban Chakrabarty,Sandeep Mallya,Harish Rotti,Deeksha Pandey,Pralhad Kushtagi,Kapaettu Satyamoorthy +8 more
TL;DR: The global and gene-specific methylation of the panel of genes identified in this study may serve as useful biomarkers for the early detection and clinical management of cervical cancer.
Journal ArticleDOI
Keeping collecting device in liquid medium is mandatory to ensure optimized liquid-based cervical cytologic sampling.
Gilbert Bigras,Malgorzata Anna Rieder,Jean-marc Lambercy,Bernard Kunz,Jean-Paul Chatelain,Olivier Reymond,Daniel Cornaz +6 more
TL;DR: The more intense the rinsing process, the less the loss, but the latter is never zero and is poorly predictable, which may have an impact on cervical cancer detection.
Journal ArticleDOI
CIN 2/3 and cervical cancer after an ASCUS pap smear. A 7-year, prospective study of the Norwegian population-based, coordinated screening program.
TL;DR: P smear follow-up of women with an ASCUS smear does not identify all women at higher risk of CIN 2/3 and ICC, and other diagnostic procedures should be implemented to improve the screening program.
References
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Natural history of cervicovaginal papillomavirus infection in young women
TL;DR: An increased risk of HPV infection was significantly associated with younger age, Hispanic ethnicity, black race, an increased number of vaginal-sex partners, high frequencies of vaginal sex and alcohol consumption, anal sex, and certain characteristics of partners.
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Natural History of Cervicovaginal Papillomavirus Infection in Young Women Gyf Ho
TL;DR: The incidence of HPV infection in sexually active young college women is high and the short duration of most HPV infections in these women suggests that the associated cervical dysplasia should be managed conservatively.
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Papillomaviruses Causing Cancer: Evasion From Host-Cell Control in Early Events in Carcinogenesis
TL;DR: Modifications in host-cell genes, most likely engaged in the control of HPV gene expression in proliferating cells, emerge as important events in HPV-mediated carcinogenesis.
Journal ArticleDOI
2001 Consensus Guidelines for the Management of Women With Cervical Cytological Abnormalities
TL;DR: Management of women with atypical squamous cells (ASC) depends on whether the Papanicolaou test is subcategorized as of undetermined significance (ASC-US) or as cannot exclude high-grade squamous intraepithelial lesion (HSIL) (asc-H).
Journal ArticleDOI
Comparison of Three Management Strategies for Patients With Atypical Squamous Cells of Undetermined Significance: Baseline Results From a Randomized Trial
TL;DR: HC 2 testing for cancer-associated HPV DNA is a viable option in the management of women with ASCUS and has greater sensitivity to detect CIN3 or above and specificity comparable to a single additional cytologic test indicating ASCUS or above.