Journal ArticleDOI
The 2001 Bethesda System: terminology for reporting results of cervical cytology.
Diane Solomon,Diane D. Davey,Robert J. Kurman,Marianne U. Prey,Stephen S. Raab,Mark E. Sherman,David C. Wilbur,Nancy A. Young +7 more
TLDR
The 2001 Bethesda System terminology reflects important advances in biological understanding of cervical neoplasia and cervical screening technology.Abstract:
ObjectivesThe Bethesda 2001 Workshop was convened to evaluate and update the 1991
Bethesda System terminology for reporting the results of cervical cytology.
A primary objective was to develop a new approach to broaden participation
in the consensus process.ParticipantsForum groups composed of 6 to 10 individuals were responsible for developing
recommendations for discussion at the workshop. Each forum group included
at least 1 cytopathologist, cytotechnologist, clinician, and international
representative to ensure a broad range of views and interests. More than 400
cytopathologists, cytotechnologists, histopathologists, family practitioners,
gynecologists, public health physicians, epidemiologists, patient advocates,
and attorneys participated in the workshop, which was convened by the National
Cancer Institute and cosponsored by 44 professional societies. More than 20
countries were represented.EvidenceLiterature review, expert opinion, and input from an Internet bulletin
board were all considered in developing recommendations. The strength of evidence
of the scientific data was considered of paramount importance.Consensus ProcessBethesda 2001 was a year-long iterative review process. An Internet
bulletin board was used for discussion of issues and drafts of recommendations.
More than 1000 comments were posted to the bulletin board over the course
of 6 months. The Bethesda Workshop, held April 30-May 2, 2001, was open to
the public. Postworkshop recommendations were posted on the bulletin board
for a last round of critical review prior to finalizing the terminology.ConclusionsBethesda 2001 was developed with broad participation in the consensus
process. The 2001 Bethesda System terminology reflects important advances
in biological understanding of cervical neoplasia and cervical screening technology.read more
Citations
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Journal Article
Genotyping for Human Papillomavirus Types 16 and 18 in Women With Minor Cervical Lesions
Marc Arbyn,Lan Xu,Freija Verdoodt,Jack Cuzick,Anne Szarewski,Jerome L. Belinson,Nicolas Wentzensen,Julia C. Gage,Michelle J. Khan +8 more
TL;DR: Testing for HPV 16/18 to triage women with minor abnormal cytology is poorly sensitive but may be useful as a second triage test after hrHPV testing, with direct referral if the woman is positive for HPV 15/18.
Journal ArticleDOI
HPV testing in first-void urine provides sensitivity for CIN2+ detection comparable with a smear taken by a clinician or a brush-based self-sample: cross-sectional data from a triage population
Annemiek Leeman,M del Pino,Anco Molijn,Agata Rodriguez,Aureli Torné,M. de Koning,Jaume Ordi,F. J. van Kemenade,David G. Jenkins,W. G. V. Quint +9 more
TL;DR: To compare the sensitivity of high‐risk human papillomavirus (hrHPV) and genotype detection in self‐collected urine samples in the morning, and later on, brush‐based self‐samples, and clinician‐taken smears for detecting cervical intraepithelial neoplasia grade 2+ (CIN2+) in a colposcopic referral population.
Journal ArticleDOI
Human papillomavirus prevalence and type-distribution among women in Zhejiang Province, Southeast China: a cross-sectional study
TL;DR: Overall HPV prevalence increased with the severity of the cytologic result, and the cervical lesion risk of HPV-infected women increased to about 26-fold of uninfected women.
Journal ArticleDOI
Precision in gynecologic cytologic interpretation: a study from the College of American Pathologists Interlaboratory Comparison Program in Cervicovaginal Cytology.
Andrew A. Renshaw,Diane D. Davey,George G. Birdsong,Molly K. Walsh,Patricia E. Styer,Dina R. Mody,Terence J. Colgan +6 more
TL;DR: The cytologic interpretations of the most significant categories (HSIL, squamous cell carcinoma, and adenocarcinoma) are less precise than those of specific infection, negative, and LSIL categories.
References
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TL;DR: The incidence of HPV infection in sexually active young college women is high and the short duration of most HPV infections in these women suggests that the associated cervical dysplasia should be managed conservatively.
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2001 Consensus Guidelines for the Management of Women With Cervical Cytological Abnormalities
TL;DR: Management of women with atypical squamous cells (ASC) depends on whether the Papanicolaou test is subcategorized as of undetermined significance (ASC-US) or as cannot exclude high-grade squamous intraepithelial lesion (HSIL) (asc-H).
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Comparison of Three Management Strategies for Patients With Atypical Squamous Cells of Undetermined Significance: Baseline Results From a Randomized Trial
TL;DR: HC 2 testing for cancer-associated HPV DNA is a viable option in the management of women with ASCUS and has greater sensitivity to detect CIN3 or above and specificity comparable to a single additional cytologic test indicating ASCUS or above.