Journal ArticleDOI
The 2001 Bethesda System: terminology for reporting results of cervical cytology.
Diane Solomon,Diane D. Davey,Robert J. Kurman,Marianne U. Prey,Stephen S. Raab,Mark E. Sherman,David C. Wilbur,Nancy A. Young +7 more
TLDR
The 2001 Bethesda System terminology reflects important advances in biological understanding of cervical neoplasia and cervical screening technology.Abstract:
ObjectivesThe Bethesda 2001 Workshop was convened to evaluate and update the 1991
Bethesda System terminology for reporting the results of cervical cytology.
A primary objective was to develop a new approach to broaden participation
in the consensus process.ParticipantsForum groups composed of 6 to 10 individuals were responsible for developing
recommendations for discussion at the workshop. Each forum group included
at least 1 cytopathologist, cytotechnologist, clinician, and international
representative to ensure a broad range of views and interests. More than 400
cytopathologists, cytotechnologists, histopathologists, family practitioners,
gynecologists, public health physicians, epidemiologists, patient advocates,
and attorneys participated in the workshop, which was convened by the National
Cancer Institute and cosponsored by 44 professional societies. More than 20
countries were represented.EvidenceLiterature review, expert opinion, and input from an Internet bulletin
board were all considered in developing recommendations. The strength of evidence
of the scientific data was considered of paramount importance.Consensus ProcessBethesda 2001 was a year-long iterative review process. An Internet
bulletin board was used for discussion of issues and drafts of recommendations.
More than 1000 comments were posted to the bulletin board over the course
of 6 months. The Bethesda Workshop, held April 30-May 2, 2001, was open to
the public. Postworkshop recommendations were posted on the bulletin board
for a last round of critical review prior to finalizing the terminology.ConclusionsBethesda 2001 was developed with broad participation in the consensus
process. The 2001 Bethesda System terminology reflects important advances
in biological understanding of cervical neoplasia and cervical screening technology.read more
Citations
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Journal ArticleDOI
Time for evidence-based cytology
TL;DR: The various facets of EBC are sampling and specimen adequacy, morphological identification and computer based expert system, integrated reporting, identification of the controversial areas and high quality researches for evidences.
Journal Article
Assessment of the Association Between Micronuclei and the Degree of Uterine Lesions and Viral Load in Women with Human Papillomavirus
Mônica Lúcia Adam,Camila Pini,Siumara Túlio,Jeanne Cristina Lapenda Lins Cantalice,Rodrigo A. Torres,Maria Tereza dos Santos Correia +5 more
TL;DR: Assessment of the association between micronucleus expression and the degree of cytological lesions and viral load in patients with HPV demonstrates the efficacy of micron nucleus analysis in monitoring risks to human health.
Journal ArticleDOI
Aberrant expression of α-dystroglycan in cervical and vulvar cancer
Alessandro Sgambato,Elisabetta Tarquini,Federica Resci,Barbara De Paola,Beatrice Faraglia,Andrea Camerini,Alessandro Rettino,Mario Migaldi,Achille Cittadini,Gian Franco Zannoni +9 more
TL;DR: Investigation of α-dystroglycan is frequently lost in human cervical and vulvar tumorigenesis and further studies are warranted to verify whether evaluation of this molecule might serve as marker of risk progression of preneoplastic lesions and to better understand its significance in terms of cancer development.
Journal ArticleDOI
Prevalence of cervical squamous intraepithelial lesions among HIV-positive women in Enugu, South-eastern Nigeria.
TL;DR: There is an association between HIV infection and SIL in Enugu, South-eastern Nigeria and cervical cancer screening should be incorporated into the antiretroviral clinics, so as to prevent the impending surge in the burden of cervical cancer in Nigeria.
Journal ArticleDOI
Comparison of the accuracy of Hybrid Capture II and polymerase chain reaction in detecting clinically important cervical dysplasia: a systematic review and meta-analysis.
Hung N. Luu,Kristina R. Dahlstrom,Patricia Dolan Mullen,Helena M. VonVille,Michael E. Scheurer +4 more
TL;DR: Based on higher test accuracy, the results support the use of HCII in cervical cancer screening programs and the role of HPV type distribution should be explored to determine the worldwide comparability of HPV test accuracy.
References
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2001 Consensus Guidelines for the Management of Women With Cervical Cytological Abnormalities
TL;DR: Management of women with atypical squamous cells (ASC) depends on whether the Papanicolaou test is subcategorized as of undetermined significance (ASC-US) or as cannot exclude high-grade squamous intraepithelial lesion (HSIL) (asc-H).
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Comparison of Three Management Strategies for Patients With Atypical Squamous Cells of Undetermined Significance: Baseline Results From a Randomized Trial
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