Journal ArticleDOI
The 2001 Bethesda System: terminology for reporting results of cervical cytology.
Diane Solomon,Diane D. Davey,Robert J. Kurman,Marianne U. Prey,Stephen S. Raab,Mark E. Sherman,David C. Wilbur,Nancy A. Young +7 more
TLDR
The 2001 Bethesda System terminology reflects important advances in biological understanding of cervical neoplasia and cervical screening technology.Abstract:
ObjectivesThe Bethesda 2001 Workshop was convened to evaluate and update the 1991
Bethesda System terminology for reporting the results of cervical cytology.
A primary objective was to develop a new approach to broaden participation
in the consensus process.ParticipantsForum groups composed of 6 to 10 individuals were responsible for developing
recommendations for discussion at the workshop. Each forum group included
at least 1 cytopathologist, cytotechnologist, clinician, and international
representative to ensure a broad range of views and interests. More than 400
cytopathologists, cytotechnologists, histopathologists, family practitioners,
gynecologists, public health physicians, epidemiologists, patient advocates,
and attorneys participated in the workshop, which was convened by the National
Cancer Institute and cosponsored by 44 professional societies. More than 20
countries were represented.EvidenceLiterature review, expert opinion, and input from an Internet bulletin
board were all considered in developing recommendations. The strength of evidence
of the scientific data was considered of paramount importance.Consensus ProcessBethesda 2001 was a year-long iterative review process. An Internet
bulletin board was used for discussion of issues and drafts of recommendations.
More than 1000 comments were posted to the bulletin board over the course
of 6 months. The Bethesda Workshop, held April 30-May 2, 2001, was open to
the public. Postworkshop recommendations were posted on the bulletin board
for a last round of critical review prior to finalizing the terminology.ConclusionsBethesda 2001 was developed with broad participation in the consensus
process. The 2001 Bethesda System terminology reflects important advances
in biological understanding of cervical neoplasia and cervical screening technology.read more
Citations
More filters
Journal ArticleDOI
Systematic review of guidelines for the assessment and management of high-grade anal intraepithelial neoplasia (AIN II/III).
TL;DR: The aim of this review was to assess and compare international/national society guidelines currently available in the literature on the management, treatment and surveillance of AIN III and to clarify the terminology used in histological assessment.
Journal ArticleDOI
Presence of 20% or more clue cells: an accurate criterion for the diagnosis of bacterial vaginosis in Papanicolaou cervical smears.
Michelle Garcia Discacciati,José Antonio Simões,Rita Goreti Amaral,Eliane Melo Brolazo,Silvia Helena Rabelo-Santos,Silvia Helena Rabelo-Santos,Maria C.A. Westin,Eliana B.L. Montemor +7 more
TL;DR: The presence of 20% or more clue cells in the Papanicolaou smear is an accurate and reproducible criterion for the diagnosis of BV and may be used in screening for this infection, eliminating the need for further vaginal sample collection.
Journal ArticleDOI
History of high-risk HPV and Pap test results in a large cohort of patients with invasive cervical carcinoma: experience from the largest women's hospital in China.
Xiang Tao,Christopher C. Griffith,Xiangrong Zhou,Zhiheng Wang,Yabin Yan,Zaibo Li,Chengquan Zhao +6 more
TL;DR: Prior screening results in a population of Chinese patients with invasive cervical carcinoma were examined to gain further insight into the role of both Pap testing and hrHPV testing.
Journal ArticleDOI
p16/ki67 and E6/E7 mRNA Accuracy and Prognostic Value in Triaging HPV DNA-Positive Women
Paolo Giorgi Rossi,Francesca Carozzi,Guglielmo Ronco,Elena Allia,Simonetta Bisanzi,Anna Gillio-Tos,Laura De Marco,Raffaella Rizzolo,Daniela Gustinucci,Annarosa Del Mistro,Helena Frayle,Massimo Confortini,Anna Iossa,Elena Cesarini,Simonetta Bulletti,Basilio Passamonti,Silvia Gori,Laura Toniolo,Alessandra Barca,Laura Bonvicini,Pamela Mancuso,Francesco Venturelli,Maria Benevolo +22 more
TL;DR: E6/E7 mRNA showed the highest sensitivity, at the price of too high a positivity rate to be efficient for triage, however, when negative, it showed a good prognostic value for clearance and CIN2+ regression.
Journal ArticleDOI
Long‐term follow‐up of women with atypical squamous cells of undetermined significance (ASCUS)
TL;DR: It is found that among ASCUS patients followed for up to 9 yr, 20% develop only low‐grade SIL or mild dysplasia and 10% develop HSIL or moderate or severe Dysplasia.
References
More filters
Journal ArticleDOI
Natural history of cervicovaginal papillomavirus infection in young women
TL;DR: An increased risk of HPV infection was significantly associated with younger age, Hispanic ethnicity, black race, an increased number of vaginal-sex partners, high frequencies of vaginal sex and alcohol consumption, anal sex, and certain characteristics of partners.
Journal ArticleDOI
Natural History of Cervicovaginal Papillomavirus Infection in Young Women Gyf Ho
TL;DR: The incidence of HPV infection in sexually active young college women is high and the short duration of most HPV infections in these women suggests that the associated cervical dysplasia should be managed conservatively.
Journal ArticleDOI
Papillomaviruses Causing Cancer: Evasion From Host-Cell Control in Early Events in Carcinogenesis
TL;DR: Modifications in host-cell genes, most likely engaged in the control of HPV gene expression in proliferating cells, emerge as important events in HPV-mediated carcinogenesis.
Journal ArticleDOI
2001 Consensus Guidelines for the Management of Women With Cervical Cytological Abnormalities
TL;DR: Management of women with atypical squamous cells (ASC) depends on whether the Papanicolaou test is subcategorized as of undetermined significance (ASC-US) or as cannot exclude high-grade squamous intraepithelial lesion (HSIL) (asc-H).
Journal ArticleDOI
Comparison of Three Management Strategies for Patients With Atypical Squamous Cells of Undetermined Significance: Baseline Results From a Randomized Trial
TL;DR: HC 2 testing for cancer-associated HPV DNA is a viable option in the management of women with ASCUS and has greater sensitivity to detect CIN3 or above and specificity comparable to a single additional cytologic test indicating ASCUS or above.