Journal ArticleDOI
The 2001 Bethesda System: terminology for reporting results of cervical cytology.
Diane Solomon,Diane D. Davey,Robert J. Kurman,Marianne U. Prey,Stephen S. Raab,Mark E. Sherman,David C. Wilbur,Nancy A. Young +7 more
TLDR
The 2001 Bethesda System terminology reflects important advances in biological understanding of cervical neoplasia and cervical screening technology.Abstract:
ObjectivesThe Bethesda 2001 Workshop was convened to evaluate and update the 1991
Bethesda System terminology for reporting the results of cervical cytology.
A primary objective was to develop a new approach to broaden participation
in the consensus process.ParticipantsForum groups composed of 6 to 10 individuals were responsible for developing
recommendations for discussion at the workshop. Each forum group included
at least 1 cytopathologist, cytotechnologist, clinician, and international
representative to ensure a broad range of views and interests. More than 400
cytopathologists, cytotechnologists, histopathologists, family practitioners,
gynecologists, public health physicians, epidemiologists, patient advocates,
and attorneys participated in the workshop, which was convened by the National
Cancer Institute and cosponsored by 44 professional societies. More than 20
countries were represented.EvidenceLiterature review, expert opinion, and input from an Internet bulletin
board were all considered in developing recommendations. The strength of evidence
of the scientific data was considered of paramount importance.Consensus ProcessBethesda 2001 was a year-long iterative review process. An Internet
bulletin board was used for discussion of issues and drafts of recommendations.
More than 1000 comments were posted to the bulletin board over the course
of 6 months. The Bethesda Workshop, held April 30-May 2, 2001, was open to
the public. Postworkshop recommendations were posted on the bulletin board
for a last round of critical review prior to finalizing the terminology.ConclusionsBethesda 2001 was developed with broad participation in the consensus
process. The 2001 Bethesda System terminology reflects important advances
in biological understanding of cervical neoplasia and cervical screening technology.read more
Citations
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Journal ArticleDOI
Follow-up study of patients with cervical intraepithelial neoplasia grade 1 overexpressing p16Ink4a.
Stefania Cortecchia,Giuseppe Galanti,Cecilia Sgadari,Silvano Costa,Margherita De Lillo,L. Caprara,Giovanni Barillari,Paolo Monini,Roberto Nannini,Barbara Ensoli,Lauro Bucchi +10 more
TL;DR: The patients with p16-positive CIN1 had an increased risk for progression that was concentrated in the first year of follow-up, and immunostaining of p16 could have a role in short-term surveillance of patients with CIN 1.
Journal ArticleDOI
Prognostic Value of HPV E6/E7 mRNA Assay in Women with Negative Colposcopy or CIN1 Histology Result: A Follow-Up Study
Paolo Giorgi Rossi,Maria Benevolo,Amina Vocaturo,Donatella Caraceni,Lucia Ciccocioppo,Antonio Frega,Irene Terrenato,Roberta Zappacosta,Deborah French,Sandra Rosini +9 more
TL;DR: E6/E7 mRNA over-expression appears to be a good candidate as a prognostic biomarker to manage HR-HPV DNA-positive women with negative colposcopy or histology, particularly in order to decrease follow-up intensity in those who are negative.
Journal ArticleDOI
Interobserver reproducibility of cytologic p16INK4a/Ki-67 dual immunostaining in human papillomavirus-positive women
Maria Benevolo,Elena Allia,Daniela Gustinucci,Francesca Rollo,Simonetta Bulletti,Elena Cesarini,Basilio Passamonti,Maria Rosaria Giovagnoli,Elisabetta Carico,Francesca Carozzi,Alessandra Mongia,Giulia Fantacci,Massimo Confortini,Teresa Rubino,Cristina Fodero,S. Prandi,Natalina Marchi,Angelo Farruggio,Anna Coccia,Luigia Macrì,B. Ghiringhello,Guglielmo Ronco,Emma Bragantini,Enzo Polla,Vincenzo Maccallini,Giovanni Negri,Paolo Giorgi Rossi +26 more
TL;DR: Dual staining for p16ink4a and Ki‐67 has been proposed as a triage test in cervical cancer screening for women who test positive for human papillomavirus DNA and interobserver reproducibility of the interpretation of this test was assessed.
Journal ArticleDOI
Clinical importance of “low-grade squamous intraepithelial lesion, cannot exclude high-grade squamous intraepithelial lesion (LSIL-H)” terminology for cervical smears: 5-year analysis of the positive predictive value of LSIL-H compared with ASC-H, LSIL, and HSIL in the detection of high-grade cervical lesions with a review of the literature
TL;DR: The results suggest that an LSIL-H diagnostic category would aid in more rapid detection and treatment in some patients with CIN 2+.
Journal ArticleDOI
Prevalence and Distribution of High-Risk Genotypes of HPV in Women with Severe Cervical Lesions in Madrid, Spain: Importance of Detecting Genotype 16 and Other High-Risk Genotypes
Maria Luisa Mateos Lindemann,Juan Manuel Sánchez Calvo,Jesús Chacón de Antonio,Itziar Huarte Sanz,Esperanza Diaz,Maria Dolores Rubio,Maria Luisa de la Morena +6 more
TL;DR: The data show that genotypes 16, 31, 58, and 52 are the most prevalent HR-HPV in cervical samples with severe intraepithelial lesion in Spain, and there may be some geographical variation in prevalence of carcinogenic types.
References
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Natural history of cervicovaginal papillomavirus infection in young women
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2001 Consensus Guidelines for the Management of Women With Cervical Cytological Abnormalities
TL;DR: Management of women with atypical squamous cells (ASC) depends on whether the Papanicolaou test is subcategorized as of undetermined significance (ASC-US) or as cannot exclude high-grade squamous intraepithelial lesion (HSIL) (asc-H).
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Comparison of Three Management Strategies for Patients With Atypical Squamous Cells of Undetermined Significance: Baseline Results From a Randomized Trial
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