Journal ArticleDOI
The 2001 Bethesda System: terminology for reporting results of cervical cytology.
Diane Solomon,Diane D. Davey,Robert J. Kurman,Marianne U. Prey,Stephen S. Raab,Mark E. Sherman,David C. Wilbur,Nancy A. Young +7 more
TLDR
The 2001 Bethesda System terminology reflects important advances in biological understanding of cervical neoplasia and cervical screening technology.Abstract:
ObjectivesThe Bethesda 2001 Workshop was convened to evaluate and update the 1991
Bethesda System terminology for reporting the results of cervical cytology.
A primary objective was to develop a new approach to broaden participation
in the consensus process.ParticipantsForum groups composed of 6 to 10 individuals were responsible for developing
recommendations for discussion at the workshop. Each forum group included
at least 1 cytopathologist, cytotechnologist, clinician, and international
representative to ensure a broad range of views and interests. More than 400
cytopathologists, cytotechnologists, histopathologists, family practitioners,
gynecologists, public health physicians, epidemiologists, patient advocates,
and attorneys participated in the workshop, which was convened by the National
Cancer Institute and cosponsored by 44 professional societies. More than 20
countries were represented.EvidenceLiterature review, expert opinion, and input from an Internet bulletin
board were all considered in developing recommendations. The strength of evidence
of the scientific data was considered of paramount importance.Consensus ProcessBethesda 2001 was a year-long iterative review process. An Internet
bulletin board was used for discussion of issues and drafts of recommendations.
More than 1000 comments were posted to the bulletin board over the course
of 6 months. The Bethesda Workshop, held April 30-May 2, 2001, was open to
the public. Postworkshop recommendations were posted on the bulletin board
for a last round of critical review prior to finalizing the terminology.ConclusionsBethesda 2001 was developed with broad participation in the consensus
process. The 2001 Bethesda System terminology reflects important advances
in biological understanding of cervical neoplasia and cervical screening technology.read more
Citations
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Journal ArticleDOI
The Accuracy of p16/Ki-67 and HPV Test in the Detection of CIN2/3 in Women Diagnosed with ASC-US or LSIL.
Júlio César Possati-Resende,José Humberto Tavares Guerreiro Fregnani,Ligia Maria Kerr,Edmundo Carvalho Mauad,Adhemar Longatto-Filho,Cristovam Scapulatempo-Neto +5 more
TL;DR: Both p16/Ki-67 double staining and the hr-HPV DNA test had similar performance in predicting high-grade cervical intraepithelial neoplasia among women with ASC-US and among women >30 years diagnosed with LSIL.
Journal ArticleDOI
Cervical screening in the 21st century: the case for human papillomavirus testing of self-collected specimens.
Brian J. Morris,Barbara Rose +1 more
TL;DR: A kit for self-collection and return to a testing laboratory, followed by practitioner notification and follow-up if required, should result in wider participation and the higher accuracy of HPV testing should lead to improved cervical cancer prevention.
Journal Article
Cervical cancer screening among HIV-positive women: Retrospective cohort study from a tertiary care HIV clinic
TL;DR: The hypothesis that those women who do not have primary care providers are less likely to undergo cervical screening is supported, as well as the high proportion of abnormal cervical screening test results among HIV-positive women.
Journal ArticleDOI
Deficiencies in myeloid antigen-presenting cells in women with cervical squamous intraepithelial lesions.
Bang Ning Lee,Michele Follen,Graciela Rodriquez,De Yu Shen,Anais Malpica,William T. Shearer,James M. Reuben +6 more
TL;DR: The functions of dendritic cells in the development of T‐cell immunity in women with cervical SILs were assessed and HPV‐related cervical squamous intraepithelial lesions were assessed.
Journal ArticleDOI
Significance of benign endometrial cells in papanicolaou tests from women aged ≥ 40 years†
TL;DR: The relative risk of hyperplasia or malignancy conferred by the presence versus the absence of BECs in Papanicolaou (Pap) tests of women aged ≥ 40 years is examined.
References
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Natural history of cervicovaginal papillomavirus infection in young women
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TL;DR: The incidence of HPV infection in sexually active young college women is high and the short duration of most HPV infections in these women suggests that the associated cervical dysplasia should be managed conservatively.
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Journal ArticleDOI
2001 Consensus Guidelines for the Management of Women With Cervical Cytological Abnormalities
TL;DR: Management of women with atypical squamous cells (ASC) depends on whether the Papanicolaou test is subcategorized as of undetermined significance (ASC-US) or as cannot exclude high-grade squamous intraepithelial lesion (HSIL) (asc-H).
Journal ArticleDOI
Comparison of Three Management Strategies for Patients With Atypical Squamous Cells of Undetermined Significance: Baseline Results From a Randomized Trial
TL;DR: HC 2 testing for cancer-associated HPV DNA is a viable option in the management of women with ASCUS and has greater sensitivity to detect CIN3 or above and specificity comparable to a single additional cytologic test indicating ASCUS or above.