Journal ArticleDOI
The 2001 Bethesda System: terminology for reporting results of cervical cytology.
Diane Solomon,Diane D. Davey,Robert J. Kurman,Marianne U. Prey,Stephen S. Raab,Mark E. Sherman,David C. Wilbur,Nancy A. Young +7 more
TLDR
The 2001 Bethesda System terminology reflects important advances in biological understanding of cervical neoplasia and cervical screening technology.Abstract:
ObjectivesThe Bethesda 2001 Workshop was convened to evaluate and update the 1991
Bethesda System terminology for reporting the results of cervical cytology.
A primary objective was to develop a new approach to broaden participation
in the consensus process.ParticipantsForum groups composed of 6 to 10 individuals were responsible for developing
recommendations for discussion at the workshop. Each forum group included
at least 1 cytopathologist, cytotechnologist, clinician, and international
representative to ensure a broad range of views and interests. More than 400
cytopathologists, cytotechnologists, histopathologists, family practitioners,
gynecologists, public health physicians, epidemiologists, patient advocates,
and attorneys participated in the workshop, which was convened by the National
Cancer Institute and cosponsored by 44 professional societies. More than 20
countries were represented.EvidenceLiterature review, expert opinion, and input from an Internet bulletin
board were all considered in developing recommendations. The strength of evidence
of the scientific data was considered of paramount importance.Consensus ProcessBethesda 2001 was a year-long iterative review process. An Internet
bulletin board was used for discussion of issues and drafts of recommendations.
More than 1000 comments were posted to the bulletin board over the course
of 6 months. The Bethesda Workshop, held April 30-May 2, 2001, was open to
the public. Postworkshop recommendations were posted on the bulletin board
for a last round of critical review prior to finalizing the terminology.ConclusionsBethesda 2001 was developed with broad participation in the consensus
process. The 2001 Bethesda System terminology reflects important advances
in biological understanding of cervical neoplasia and cervical screening technology.read more
Citations
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Journal ArticleDOI
A Phase II, Prospective, Randomized, Multicenter, Open-Label Study of GX-188E, an HPV DNA Vaccine, in Patients with Cervical Intraepithelial Neoplasia 3
Youn Jin Choi,Soo Young Hur,Tae Jin Kim,Sung Ran Hong,Jae Kwan Lee,Chi Heum Cho,Ki Seok Park,Jung Won Woo,Young Chul Sung,You Suk Suh,Jong Sup Park +10 more
TL;DR: GX-188E is an effective therapeutic vaccine against a cohort containing only CIN3 patients, and the HPV type 16 E6/E7 variants D25E, V83L, and N29S were inversely associated with histopathologic regression at V8.
Journal ArticleDOI
The epidemiology of human papillomavirus infection in HIV-positive and HIV-negative high-risk women in Kigali, Rwanda
Nienke J. Veldhuijzen,Sarah L. Braunstein,Joseph Vyankandondera,Chantal M. Ingabire,Justin Ntirushwa,Evelyne Kestelyn,Coosje J. Tuijn,Ferdinand W. N. M. Wit,Aline Umutoni,Mireille Uwineza,Tania Crucitti,Janneke van de Wijgert +11 more
TL;DR: High HPV prevalence, incidence and persistence were found among high-risk women in Kigali, Rwanda; HPV52 had the highest incidence; and, together with HPV33 and HPV58, were strongly associated with acquisition of other HR-HPV types in HIV-negative women.
Journal ArticleDOI
Analysis of abnormal epithelial lesions in cervical Pap smears in Mid-Western Nepal
TL;DR: At least one Pap screening test of the cervix of all women between the ages of 40-50 years is recommended and eighty per cent of all the abnormal epithelial lesions were found in women above the age of 40 years.
Journal ArticleDOI
Recommendations for cervical cancer screening programs in developing countries: the need for equity and technological development
TL;DR: The cervical cancer screening programs (CCSP) have not been very efficient in the developing countries, so the need to foster changes on policies, standards, quality control mechanisms, evaluation and integration of new screening alternatives considered as low and high cost, as well as to regulate colposcopy practices and the foundation of HPV laboratories.
Journal ArticleDOI
Clinicopathological importance of Papanicolaou smears for the diagnosis of premalignant and malignant lesions of the cervix.
Mulazim Hussain Bukhari,Kanwal Saba,Samina Qamar,Muhammad Muddasar Majeed,Shahida Niazi,Samina Naeem +5 more
TL;DR: It is clear that cervical neoplastic lesions are becoming a problem in Pakistan and conventional Papanicolaou (Pap) smears are well suited for diagnosing neoplastics disease.
References
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Journal ArticleDOI
Natural history of cervicovaginal papillomavirus infection in young women
TL;DR: An increased risk of HPV infection was significantly associated with younger age, Hispanic ethnicity, black race, an increased number of vaginal-sex partners, high frequencies of vaginal sex and alcohol consumption, anal sex, and certain characteristics of partners.
Journal ArticleDOI
Natural History of Cervicovaginal Papillomavirus Infection in Young Women Gyf Ho
TL;DR: The incidence of HPV infection in sexually active young college women is high and the short duration of most HPV infections in these women suggests that the associated cervical dysplasia should be managed conservatively.
Journal ArticleDOI
Papillomaviruses Causing Cancer: Evasion From Host-Cell Control in Early Events in Carcinogenesis
TL;DR: Modifications in host-cell genes, most likely engaged in the control of HPV gene expression in proliferating cells, emerge as important events in HPV-mediated carcinogenesis.
Journal ArticleDOI
2001 Consensus Guidelines for the Management of Women With Cervical Cytological Abnormalities
TL;DR: Management of women with atypical squamous cells (ASC) depends on whether the Papanicolaou test is subcategorized as of undetermined significance (ASC-US) or as cannot exclude high-grade squamous intraepithelial lesion (HSIL) (asc-H).
Journal ArticleDOI
Comparison of Three Management Strategies for Patients With Atypical Squamous Cells of Undetermined Significance: Baseline Results From a Randomized Trial
TL;DR: HC 2 testing for cancer-associated HPV DNA is a viable option in the management of women with ASCUS and has greater sensitivity to detect CIN3 or above and specificity comparable to a single additional cytologic test indicating ASCUS or above.