Journal ArticleDOI
The 2001 Bethesda System: terminology for reporting results of cervical cytology.
Diane Solomon,Diane D. Davey,Robert J. Kurman,Marianne U. Prey,Stephen S. Raab,Mark E. Sherman,David C. Wilbur,Nancy A. Young +7 more
TLDR
The 2001 Bethesda System terminology reflects important advances in biological understanding of cervical neoplasia and cervical screening technology.Abstract:
ObjectivesThe Bethesda 2001 Workshop was convened to evaluate and update the 1991
Bethesda System terminology for reporting the results of cervical cytology.
A primary objective was to develop a new approach to broaden participation
in the consensus process.ParticipantsForum groups composed of 6 to 10 individuals were responsible for developing
recommendations for discussion at the workshop. Each forum group included
at least 1 cytopathologist, cytotechnologist, clinician, and international
representative to ensure a broad range of views and interests. More than 400
cytopathologists, cytotechnologists, histopathologists, family practitioners,
gynecologists, public health physicians, epidemiologists, patient advocates,
and attorneys participated in the workshop, which was convened by the National
Cancer Institute and cosponsored by 44 professional societies. More than 20
countries were represented.EvidenceLiterature review, expert opinion, and input from an Internet bulletin
board were all considered in developing recommendations. The strength of evidence
of the scientific data was considered of paramount importance.Consensus ProcessBethesda 2001 was a year-long iterative review process. An Internet
bulletin board was used for discussion of issues and drafts of recommendations.
More than 1000 comments were posted to the bulletin board over the course
of 6 months. The Bethesda Workshop, held April 30-May 2, 2001, was open to
the public. Postworkshop recommendations were posted on the bulletin board
for a last round of critical review prior to finalizing the terminology.ConclusionsBethesda 2001 was developed with broad participation in the consensus
process. The 2001 Bethesda System terminology reflects important advances
in biological understanding of cervical neoplasia and cervical screening technology.read more
Citations
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Journal ArticleDOI
Triage of atypical squamous cells of undetermined significance with hybrid capture II: colposcopy and histologic human papillomavirus correlation.
TL;DR: Hybrid Capture II returned negative in 25% of cases with biopsy-proven high-grade CIN with associated high-risk HPV DNA by PCR (non-Premalignant ASCUS subset), and positive in 39.3% of Cases with normal results; this limits its clinical utility.
Journal ArticleDOI
Screening anal dysplasia in HIV-infected patients: is there an agreement between anal pap smear and high-resolution anoscopy-guided biopsy?
Caio Sergio Rizkallah Nahas,Edesio Vieira da Silva Filho,Aluísio Augusto Cotrim Segurado,Raphael F.F. Genevcius,Renê Gerhard,Eliana Battaggia Gutierrez,Carlos Frederico Sparapan Marques,Ivan Cecconello,Sergio Carlos Nahas +8 more
TL;DR: Anal Pap smears alone were not sensitive enough to rule out anal dysplasia, and high-resolution anoscopy-guided biopsy should be incorporated as a complementary screening test for anal Dysplasia in high-risk patients.
Journal ArticleDOI
Human papillomavirus oncogenic mRNA testing for cervical cancer screening: baseline and longitudinal results from the CLEAR study.
Jennifer Reid,Thomas C. Wright,Mark H. Stoler,Jack Cuzick,Philip E. Castle,Janel Dockter,Damon K. Getman,Cristina Giachetti +7 more
TL;DR: These results support the use of AHPV as a safe and effective adjunctive cervical cancer screening method and suggest a very low risk of CIN2+ in women negative by either human papillomavirus test after 3 years of follow-up.
Journal ArticleDOI
Prevalence of human papillomavirus infection in women in Benin, West Africa.
Franca Piras,Michela Piga,Antonella De Montis,Ahissou R F Zannou,Luigi Minerba,Maria Teresa Perra,Daniela Murtas,Manuela Atzori,Marco Pittau,Cristina Maxia,Paola Sirigu +10 more
TL;DR: This study provides the first estimates of the prevalence of HPV and type-specific distribution among women from Benin and demonstrates that the epidemiology of HPV infection in Benin is different from that of other world regions.
Journal ArticleDOI
New Bethesda terminology and evidence-based management guidelines for cervical cytology findings.
TL;DR: The Atypical Squamous Cells of Undetermined Significance–Low-grade Squamous Intraepithelial Lesion Triage Study (ALTS), which is sponsored by the National Cancer Institute, has published several articles presenting long-awaited data regarding the utility of human papillomavirus testing in the context of cervical cancer screening.
References
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Journal ArticleDOI
Natural history of cervicovaginal papillomavirus infection in young women
TL;DR: An increased risk of HPV infection was significantly associated with younger age, Hispanic ethnicity, black race, an increased number of vaginal-sex partners, high frequencies of vaginal sex and alcohol consumption, anal sex, and certain characteristics of partners.
Journal ArticleDOI
Natural History of Cervicovaginal Papillomavirus Infection in Young Women Gyf Ho
TL;DR: The incidence of HPV infection in sexually active young college women is high and the short duration of most HPV infections in these women suggests that the associated cervical dysplasia should be managed conservatively.
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Papillomaviruses Causing Cancer: Evasion From Host-Cell Control in Early Events in Carcinogenesis
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Journal ArticleDOI
2001 Consensus Guidelines for the Management of Women With Cervical Cytological Abnormalities
TL;DR: Management of women with atypical squamous cells (ASC) depends on whether the Papanicolaou test is subcategorized as of undetermined significance (ASC-US) or as cannot exclude high-grade squamous intraepithelial lesion (HSIL) (asc-H).
Journal ArticleDOI
Comparison of Three Management Strategies for Patients With Atypical Squamous Cells of Undetermined Significance: Baseline Results From a Randomized Trial
TL;DR: HC 2 testing for cancer-associated HPV DNA is a viable option in the management of women with ASCUS and has greater sensitivity to detect CIN3 or above and specificity comparable to a single additional cytologic test indicating ASCUS or above.