Journal ArticleDOI
The 2001 Bethesda System: terminology for reporting results of cervical cytology.
Diane Solomon,Diane D. Davey,Robert J. Kurman,Marianne U. Prey,Stephen S. Raab,Mark E. Sherman,David C. Wilbur,Nancy A. Young +7 more
TLDR
The 2001 Bethesda System terminology reflects important advances in biological understanding of cervical neoplasia and cervical screening technology.Abstract:
ObjectivesThe Bethesda 2001 Workshop was convened to evaluate and update the 1991
Bethesda System terminology for reporting the results of cervical cytology.
A primary objective was to develop a new approach to broaden participation
in the consensus process.ParticipantsForum groups composed of 6 to 10 individuals were responsible for developing
recommendations for discussion at the workshop. Each forum group included
at least 1 cytopathologist, cytotechnologist, clinician, and international
representative to ensure a broad range of views and interests. More than 400
cytopathologists, cytotechnologists, histopathologists, family practitioners,
gynecologists, public health physicians, epidemiologists, patient advocates,
and attorneys participated in the workshop, which was convened by the National
Cancer Institute and cosponsored by 44 professional societies. More than 20
countries were represented.EvidenceLiterature review, expert opinion, and input from an Internet bulletin
board were all considered in developing recommendations. The strength of evidence
of the scientific data was considered of paramount importance.Consensus ProcessBethesda 2001 was a year-long iterative review process. An Internet
bulletin board was used for discussion of issues and drafts of recommendations.
More than 1000 comments were posted to the bulletin board over the course
of 6 months. The Bethesda Workshop, held April 30-May 2, 2001, was open to
the public. Postworkshop recommendations were posted on the bulletin board
for a last round of critical review prior to finalizing the terminology.ConclusionsBethesda 2001 was developed with broad participation in the consensus
process. The 2001 Bethesda System terminology reflects important advances
in biological understanding of cervical neoplasia and cervical screening technology.read more
Citations
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Journal ArticleDOI
Cervical Precancer Risk in HIV-Infected Women Who Test Positive for Oncogenic Human Papillomavirus Despite a Normal Pap Test
Marla J. Keller,Robert D. Burk,L. Stewart Massad,Isam-Eldin Eltoum,Nancy A. Hessol,Philip E. Castle,Kathryn Anastos,Xianhong Xie,Howard Minkoff,Xiaonan Xue,Gypsyamber D'Souza,Lisa Flowers,Alexandra M. Levine,Christine Colie,Lisa Rahangdale,Margaret A. Fischl,Joel M. Palefsky,Howard D. Strickler +17 more
TL;DR: HIV-infected women with a normal Pap result who test HPV16 positive have high precancer risk (similar to those with LSIL), possibly warranting immediate colposcopy.
Journal ArticleDOI
Prevalence, Incidence, and Clearance of Anal High-Risk Human Papillomavirus Infection Among HIV-Infected Men in the SUN Study
Pragna Patel,Tim Bush,Erna M. Kojic,Lois Conley,Elizabeth R. Unger,Teresa M. Darragh,Keith Henry,John A. Hammer,Gerome Escota,Joel M. Palefsky,John T. Brooks +10 more
TL;DR: MSM had higher prevalence and incidence of HPV than MSW, but similar clearance, and receptive anal sex was associated with persistent HPV 16, which may predict cancer risk among HIV-infected MSM.
Journal ArticleDOI
Liquid-Based Papanicolaou Tests in Endometrial Carcinoma Diagnosis Performance, Error Root Cause Analysis, and Quality Improvement
TL;DR: It is concluded that system redesign of liquid-based Pap test screening processes has the potential to improve sensitivity in endometrial carcinoma diagnosis.
Journal ArticleDOI
Atypical glandular cells--an update.
TL;DR: The diagnostic category of atypical glandular cells (AGC) in the Bethesda system for the reporting of cervicovaginal cytology has undergone significant modification since its inception in 1988 and this article provides a comprehensive clinicopathologic review of the category.
Journal ArticleDOI
Conventional Pap smear and liquid-based cytology as screening tools in low-resource settings in Latin America: experience of the Latin American screening study.
Adhemar Longatto-Filho,Marina Yoshiê Sakamoto Maeda,Mojca Erzen,Margherita Branca,Cecilia Roteli-Martins,Paulo Naud,Sophie Françoise Mauricette Derchain,Luciano Serpa Hammes,Jean Carlos de Matos,Renata Clementino Gontijo,Luis Otávio Sarian,Temístocles P. Lima,Silvio Tatti,Stina Syrjänen,Kari Syrjänen +14 more
TL;DR: The detection rates for high grade lesions after an atypical squamous cells of undetermined significance diagnosis were similar with the 3 techniques, and the conventional Pap smear had the highest SE, while Autocyte PREP had 100% SP and PPV in detecting CIN3 with the HSIL cutoff.
References
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Natural history of cervicovaginal papillomavirus infection in young women
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Journal ArticleDOI
2001 Consensus Guidelines for the Management of Women With Cervical Cytological Abnormalities
TL;DR: Management of women with atypical squamous cells (ASC) depends on whether the Papanicolaou test is subcategorized as of undetermined significance (ASC-US) or as cannot exclude high-grade squamous intraepithelial lesion (HSIL) (asc-H).
Journal ArticleDOI
Comparison of Three Management Strategies for Patients With Atypical Squamous Cells of Undetermined Significance: Baseline Results From a Randomized Trial
TL;DR: HC 2 testing for cancer-associated HPV DNA is a viable option in the management of women with ASCUS and has greater sensitivity to detect CIN3 or above and specificity comparable to a single additional cytologic test indicating ASCUS or above.