Journal ArticleDOI
The 2001 Bethesda System: terminology for reporting results of cervical cytology.
Diane Solomon,Diane D. Davey,Robert J. Kurman,Marianne U. Prey,Stephen S. Raab,Mark E. Sherman,David C. Wilbur,Nancy A. Young +7 more
TLDR
The 2001 Bethesda System terminology reflects important advances in biological understanding of cervical neoplasia and cervical screening technology.Abstract:
ObjectivesThe Bethesda 2001 Workshop was convened to evaluate and update the 1991
Bethesda System terminology for reporting the results of cervical cytology.
A primary objective was to develop a new approach to broaden participation
in the consensus process.ParticipantsForum groups composed of 6 to 10 individuals were responsible for developing
recommendations for discussion at the workshop. Each forum group included
at least 1 cytopathologist, cytotechnologist, clinician, and international
representative to ensure a broad range of views and interests. More than 400
cytopathologists, cytotechnologists, histopathologists, family practitioners,
gynecologists, public health physicians, epidemiologists, patient advocates,
and attorneys participated in the workshop, which was convened by the National
Cancer Institute and cosponsored by 44 professional societies. More than 20
countries were represented.EvidenceLiterature review, expert opinion, and input from an Internet bulletin
board were all considered in developing recommendations. The strength of evidence
of the scientific data was considered of paramount importance.Consensus ProcessBethesda 2001 was a year-long iterative review process. An Internet
bulletin board was used for discussion of issues and drafts of recommendations.
More than 1000 comments were posted to the bulletin board over the course
of 6 months. The Bethesda Workshop, held April 30-May 2, 2001, was open to
the public. Postworkshop recommendations were posted on the bulletin board
for a last round of critical review prior to finalizing the terminology.ConclusionsBethesda 2001 was developed with broad participation in the consensus
process. The 2001 Bethesda System terminology reflects important advances
in biological understanding of cervical neoplasia and cervical screening technology.read more
Citations
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Journal ArticleDOI
Adolescent cervical dysplasia: histologic evaluation, treatment, and outcomes
Kathleen N. Moore,Amanda Cofer,Leslie Elliot,Grainger Lanneau,Joan L. Walker,Michael A. Gold +5 more
TL;DR: The observation supports continued vigilance in the evaluation of adolescents but suggests that less intervention for CIN 2 may be acceptable, which is present in 35% of the cohort.
Journal ArticleDOI
Adherence to guidelines for follow-up of low-grade cytologic abnormalities among medically underserved women.
TL;DR: More than one half of the women studied were not followed up in accordance with the established guidelines for managing abnormal cervical cytology, and factors such as age and race or ethnicity influence whether women with cytologic abnormalities receive appropriate follow-up.
Journal ArticleDOI
Efficacy, Safety, and Immunogenicity of an Escherichia coli-Produced Bivalent Human Papillomavirus Vaccine: An Interim Analysis of a Randomized Clinical Trial
You-Lin Qiao,Ting Wu,Rong-Cheng Li,Yuemei Hu,Lihui Wei,Changgui Li,Wen Chen,Shoujie Huang,Fang-Hui Zhao,Mingqiang Li,Qin-Jing Pan,Xun Zhang,Qing Li,Ying Hong,Chao Zhao,Wen-hua Zhang,Yanping Li,Kai Chu,Mei Li,Yun-Fei Jiang,Juan Li,Hui Zhao,Zhijie Lin,Xuelian Cui,Wen-Yu Liu,Caihong Li,Dong-Ping Guo,Li-Dong Ke,Xin Wu,Jie Tang,Guo-Qi Gao,Ba-Yi Li,Bin Zhao,Fengxian Zheng,Cui-Hong Dai,Meng Guo,Jun Zhao,Yingying Su,Junzhi Wang,Fengcai Zhu,Shaowei Li,Huirong Pan,Yimin Li,Jun Zhang,Ningshao Xia +44 more
TL;DR: The Escherichia coli-produced HPV- 16/18 vaccine is well tolerated and highly efficacious against HPV-16/18 associated high-grade genital lesions and persistent infection in women.
Journal ArticleDOI
Measurement characteristics of anal cytology, histopathology, and high-resolution anoscopic visual impression in an anal dysplasia screening program.
TL;DR: The reproducibility of key screening measures is moderate at best but of similar magnitude to that of other studies of anal and cervical dysplasia screening, which suggests standardization and improvement of measurement methods are essential.
Journal ArticleDOI
Five-year risks of CIN 3+ and cervical cancer among women with HPV testing of ASC-US Pap results.
Hormuzd A. Katki,Mark Schiffman,Philip E. Castle,Barbara Fetterman,Nancy Poitras,Thomas Lorey,Li C. Cheung,Tina Raine-Bennett,Julia C. Gage,Walter Kinney +9 more
TL;DR: The findings support the equal management of women with HPV-negative/ASC-US and those with Pap-negative alone, except for exiting women from screening because cancer risks at ages 60 to 64 years may be higher for women testing HPV- negative/ ASC-US.
References
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Natural history of cervicovaginal papillomavirus infection in young women
TL;DR: An increased risk of HPV infection was significantly associated with younger age, Hispanic ethnicity, black race, an increased number of vaginal-sex partners, high frequencies of vaginal sex and alcohol consumption, anal sex, and certain characteristics of partners.
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Journal ArticleDOI
2001 Consensus Guidelines for the Management of Women With Cervical Cytological Abnormalities
TL;DR: Management of women with atypical squamous cells (ASC) depends on whether the Papanicolaou test is subcategorized as of undetermined significance (ASC-US) or as cannot exclude high-grade squamous intraepithelial lesion (HSIL) (asc-H).
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Comparison of Three Management Strategies for Patients With Atypical Squamous Cells of Undetermined Significance: Baseline Results From a Randomized Trial
TL;DR: HC 2 testing for cancer-associated HPV DNA is a viable option in the management of women with ASCUS and has greater sensitivity to detect CIN3 or above and specificity comparable to a single additional cytologic test indicating ASCUS or above.