Journal ArticleDOI
The 2001 Bethesda System: terminology for reporting results of cervical cytology.
Diane Solomon,Diane D. Davey,Robert J. Kurman,Marianne U. Prey,Stephen S. Raab,Mark E. Sherman,David C. Wilbur,Nancy A. Young +7 more
TLDR
The 2001 Bethesda System terminology reflects important advances in biological understanding of cervical neoplasia and cervical screening technology.Abstract:
ObjectivesThe Bethesda 2001 Workshop was convened to evaluate and update the 1991
Bethesda System terminology for reporting the results of cervical cytology.
A primary objective was to develop a new approach to broaden participation
in the consensus process.ParticipantsForum groups composed of 6 to 10 individuals were responsible for developing
recommendations for discussion at the workshop. Each forum group included
at least 1 cytopathologist, cytotechnologist, clinician, and international
representative to ensure a broad range of views and interests. More than 400
cytopathologists, cytotechnologists, histopathologists, family practitioners,
gynecologists, public health physicians, epidemiologists, patient advocates,
and attorneys participated in the workshop, which was convened by the National
Cancer Institute and cosponsored by 44 professional societies. More than 20
countries were represented.EvidenceLiterature review, expert opinion, and input from an Internet bulletin
board were all considered in developing recommendations. The strength of evidence
of the scientific data was considered of paramount importance.Consensus ProcessBethesda 2001 was a year-long iterative review process. An Internet
bulletin board was used for discussion of issues and drafts of recommendations.
More than 1000 comments were posted to the bulletin board over the course
of 6 months. The Bethesda Workshop, held April 30-May 2, 2001, was open to
the public. Postworkshop recommendations were posted on the bulletin board
for a last round of critical review prior to finalizing the terminology.ConclusionsBethesda 2001 was developed with broad participation in the consensus
process. The 2001 Bethesda System terminology reflects important advances
in biological understanding of cervical neoplasia and cervical screening technology.read more
Citations
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Journal ArticleDOI
Anal human papillomavirus infection: prevalence, diagnosis and treatment of related lesions
TL;DR: This review summarizes the current understanding of anal HPV infection, discussing its epidemiology and risk factors in various populations, and the state of the art in the detection of anus HPV infection and its related lesions through both cytology and histology.
Journal ArticleDOI
Prevalence of human papillomavirus genotypes in cytologic abnormalities from unvaccinated women living in north-western Spain
Ana Pastora Otero-Motta,José Luis Ordóñez,Rafael González-Celador,Belen Rivas,María Del Carmen García Macías,Agustín Bullón,María Del Mar Abad +6 more
TL;DR: The prevalence of human papillomavirus genotypes in cytologic abnormalities from unvaccinated women living in north‐western Spain is low, but the number of cases is high and the risks of adverse events are high.
Journal ArticleDOI
Interaction between glutathione-S-transferase polymorphisms, smoking habit, and HPV infection in cervical cancer risk.
Selena Palma,Flavia Novelli,Luca Padua,Aldo Venuti,Grazia Prignano,Luciano Mariani,Renata Cozzi,Donatella Tirindelli,Antonella Testa +8 more
TL;DR: It is suggested that the investigation of multiple gene polymorphisms, versus single genes, could contribute to a better understanding of the effect of susceptibility genes on cancer risk, and be related to a 5.7-fold increased risk of developing CLs.
Journal ArticleDOI
Impact of human papillomavirus vaccination on the clinical meaning of cervical screening results.
Philip E. Castle,Xianhong Xie,Xiaonan Xue,Nancy Poitras,Thomas Lorey,Walter Kinney,Nicolas Wentzensen,Howard D. Strickler,Emily A. Burger,Mark Schiffman +9 more
TL;DR: The data support initiating cervical screening at an older age or changing the management of a low-grade cytology result in women aged 21-24 years who were vaccinated against HPV younger than age of 18 years.
Journal ArticleDOI
Evaluation of the Oncogenic Human Papillomavirus DNA Test with Liquid-Based Cytology in Primary Cervical Cancer Screening and the Importance of the ASC/SIL Ratio: A Belgian Study
TL;DR: The prevalence in this study was similar to that derived from meta-analyses of European studies, and the ASC/SIL ratio was within the lower and upper limits proposed in the literature, which tends to prove the good quality diagnosis of cervical smears in the laboratory.
References
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Natural history of cervicovaginal papillomavirus infection in young women
TL;DR: An increased risk of HPV infection was significantly associated with younger age, Hispanic ethnicity, black race, an increased number of vaginal-sex partners, high frequencies of vaginal sex and alcohol consumption, anal sex, and certain characteristics of partners.
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Natural History of Cervicovaginal Papillomavirus Infection in Young Women Gyf Ho
TL;DR: The incidence of HPV infection in sexually active young college women is high and the short duration of most HPV infections in these women suggests that the associated cervical dysplasia should be managed conservatively.
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Papillomaviruses Causing Cancer: Evasion From Host-Cell Control in Early Events in Carcinogenesis
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Journal ArticleDOI
2001 Consensus Guidelines for the Management of Women With Cervical Cytological Abnormalities
TL;DR: Management of women with atypical squamous cells (ASC) depends on whether the Papanicolaou test is subcategorized as of undetermined significance (ASC-US) or as cannot exclude high-grade squamous intraepithelial lesion (HSIL) (asc-H).
Journal ArticleDOI
Comparison of Three Management Strategies for Patients With Atypical Squamous Cells of Undetermined Significance: Baseline Results From a Randomized Trial
TL;DR: HC 2 testing for cancer-associated HPV DNA is a viable option in the management of women with ASCUS and has greater sensitivity to detect CIN3 or above and specificity comparable to a single additional cytologic test indicating ASCUS or above.