Journal ArticleDOI
The core promoter: At the heart of gene expression.
TLDR
A broad spectrum of studies that highlight the importance of the core promoter and its pivotal role in the regulation of metazoan gene expression are reviewed and future research directions and challenges are suggested.About:
This article is published in Biochimica et Biophysica Acta.The article was published on 2015-08-01. It has received 140 citations till now. The article focuses on the topics: Enhancer RNAs & Transcription factor II D.read more
Citations
More filters
Posted ContentDOI
Selective activation of alternative MYC core promoters by Wnt-responsive enhancers
TL;DR: It is found that P1 and P2 can be differentially regulated across cell-types, and that their selective usage is largely mediated by distal regulatory sequences.
Posted ContentDOI
Transcription start site heterogeneity and its role in RNA fate determination distinguish HIV-1 from other retroviruses and are mediated by core promoter elements
TL;DR: HIV-1 uses heterogeneous transcription start sites (TSSs) to generate two RNA 5' isoforms that adopt radically different structures and perform distinct replication functions as mentioned in this paper .
Journal ArticleDOI
The association of gene polymorphisms with milk production and mastitis resistance phenotypic traits in dairy cattle
TL;DR: In this article , the association between gene polymorphisms (SNPs) and mastitis indicators and their relationship with milk production profitability in dairy herd was evaluated. But none of the five studied SNPs were related to protein content.
Journal ArticleDOI
Synthesis of tetrahedron DNA nanostructures for detecting the activation of cell signal transduction via their specific binding to transcriptional factors.
TL;DR: Tetrahedron DNA nanostructures which contain specific binding sequences of TFs could specifically bind to activated TFs of hypoxia signaling or TGF-β signaling and this work develops a novel and effective tool to examine the activation of intracellular signaling pathways via nanotechnology.
References
More filters
Journal ArticleDOI
RNA-Seq: a revolutionary tool for transcriptomics
TL;DR: The RNA-Seq approach to transcriptome profiling that uses deep-sequencing technologies provides a far more precise measurement of levels of transcripts and their isoforms than other methods.
Journal ArticleDOI
Rapid production of full-length cDNAs from rare transcripts: amplification using a single gene-specific oligonucleotide primer
TL;DR: The efficacy of this cDNA cloning strategy was demonstrated by isolating cDNA clones of mRNA from int-2, a mouse gene that expresses four different transcripts at low abundance, the longest of which is approximately 2.9 kilobases.
Journal ArticleDOI
The Role of Chromatin during Transcription
TL;DR: This Review highlights advances in the understanding of chromatin regulation and discusses how such regulation affects the binding of transcription factors as well as the initiation and elongation steps of transcription.
Journal ArticleDOI
The mechanism of eukaryotic translation initiation and principles of its regulation
TL;DR: This work has provided a solid foundation for studying the regulation of translation initiation by mechanisms that include the modulation of initiation factor activity and through sequence-specific RNA-binding proteins and microRNAs (which affect individual mRNAs).
Journal ArticleDOI
RNA Maps Reveal New RNA Classes and a Possible Function for Pervasive Transcription
Philipp Kapranov,Jill Cheng,Sujit Dike,David A. Nix,Radharani Duttagupta,Aarron T. Willingham,Peter F. Stadler,Jana Hertel,Jörg Hackermüller,Ivo L. Hofacker,Ian Bell,Evelyn Cheung,Jorg Drenkow,Erica Dumais,Sandeep Patel,Gregg Helt,Madhavan Ganesh,Srinka Ghosh,Antonio Piccolboni,Victor Sementchenko,Hari Tammana,Thomas R. Gingeras +21 more
TL;DR: Three potentially functional classes of RNAs have been identified, two of which are syntenically conserved and correlate with the expression state of protein-coding genes and support a highly interleaved organization of the human transcriptome.
Related Papers (5)
Metazoan promoters: emerging characteristics and insights into transcriptional regulation
Genome-wide analysis of mammalian promoter architecture and evolution
Piero Carninci,Albin Sandelin,Boris Lenhard,Boris Lenhard,Shintaro Katayama,Kazuro Shimokawa,Jasmina Ponjavic,Colin A. Semple,Martin S. Taylor,Pär G. Engström,Martin C. Frith,Alistair R. R. Forrest,Wynand Alkema,Sin Lam Tan,Charles Plessy,Rimantas Kodzius,Timothy Ravasi,Timothy Ravasi,Takeya Kasukawa,Shiro Fukuda,Mutsumi Kanamori-Katayama,Yayoi Kitazume,Hideya Kawaji,Chikatoshi Kai,Mari M. Nakamura,Hideaki Konno,Kenji Nakano,Salim Mottagui-Tabar,Salim Mottagui-Tabar,Salim Mottagui-Tabar,Peter Arner,Alessandra Chesi,Stefano Gustincich,Francesca Persichetti,Harukazu Suzuki,Sean M. Grimmond,Christine A. Wells,Valerio Orlando,Claes Wahlestedt,Claes Wahlestedt,Edison T. Liu,Matthias Harbers,Jun Kawai,Vladimir B. Bajic,Vladimir B. Bajic,David A. Hume,Yoshihide Hayashizaki,Yoshihide Hayashizaki +47 more