Journal ArticleDOI
The core promoter: At the heart of gene expression.
TLDR
A broad spectrum of studies that highlight the importance of the core promoter and its pivotal role in the regulation of metazoan gene expression are reviewed and future research directions and challenges are suggested.About:
This article is published in Biochimica et Biophysica Acta.The article was published on 2015-08-01. It has received 140 citations till now. The article focuses on the topics: Enhancer RNAs & Transcription factor II D.read more
Citations
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Journal ArticleDOI
So close, no matter how far: multiple paths connecting transcription to mRNA translation in eukaryotes
Boris Slobodin,Rivka Dikstein +1 more
TL;DR: The emerging global picture suggests evolutionarily conserved regulation and coordination between transcription and mRNA translation, indicating the importance of this phenomenon for the fine‐tuning of gene expression and the adjustment to constantly changing conditions.
Journal ArticleDOI
SAGA and TFIID: Friends of TBP drifting apart.
TL;DR: Comparing the SAGA and TFIID complexes with respect to their shared subunits, structural organization, enzymatic activities and chromatin binding suggests that these complexes evolved to control the activity of TBP (TATA-binding protein) in directing the assembly of transcription initiation complexes.
Journal ArticleDOI
Modulating transcription through development of semi-synthetic yeast core promoters.
TL;DR: The core promoter structure of the well-characterized yeast TEF1 promoter was elucidated and the minimal length needed for sufficient protein expression was determined, which resulted in a group of short, 69 bp promoters with an 8.0-fold expression range.
Journal ArticleDOI
Evolution of Diverse Strategies for Promoter Regulation.
TL;DR: In this paper, the importance of DNA structure in the evolutionary adaptation of promoter sequences has been highlighted, highlighting the importance that DNA structure plays an important role in the evolution of gene transcription.
Journal ArticleDOI
The AtMYB12 activation domain maps to a short C-terminal region of the transcription factor.
TL;DR: The deletion of the last 46 C-terminal amino acids did not affect the activation capacity, but the deletion ofthe last 98 amino acids almost totally abolished transactivation of two different target promoters.
References
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Journal ArticleDOI
RNA-Seq: a revolutionary tool for transcriptomics
TL;DR: The RNA-Seq approach to transcriptome profiling that uses deep-sequencing technologies provides a far more precise measurement of levels of transcripts and their isoforms than other methods.
Journal ArticleDOI
Rapid production of full-length cDNAs from rare transcripts: amplification using a single gene-specific oligonucleotide primer
TL;DR: The efficacy of this cDNA cloning strategy was demonstrated by isolating cDNA clones of mRNA from int-2, a mouse gene that expresses four different transcripts at low abundance, the longest of which is approximately 2.9 kilobases.
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The Role of Chromatin during Transcription
TL;DR: This Review highlights advances in the understanding of chromatin regulation and discusses how such regulation affects the binding of transcription factors as well as the initiation and elongation steps of transcription.
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The mechanism of eukaryotic translation initiation and principles of its regulation
TL;DR: This work has provided a solid foundation for studying the regulation of translation initiation by mechanisms that include the modulation of initiation factor activity and through sequence-specific RNA-binding proteins and microRNAs (which affect individual mRNAs).
Journal ArticleDOI
RNA Maps Reveal New RNA Classes and a Possible Function for Pervasive Transcription
Philipp Kapranov,Jill Cheng,Sujit Dike,David A. Nix,Radharani Duttagupta,Aarron T. Willingham,Peter F. Stadler,Jana Hertel,Jörg Hackermüller,Ivo L. Hofacker,Ian Bell,Evelyn Cheung,Jorg Drenkow,Erica Dumais,Sandeep Patel,Gregg Helt,Madhavan Ganesh,Srinka Ghosh,Antonio Piccolboni,Victor Sementchenko,Hari Tammana,Thomas R. Gingeras +21 more
TL;DR: Three potentially functional classes of RNAs have been identified, two of which are syntenically conserved and correlate with the expression state of protein-coding genes and support a highly interleaved organization of the human transcriptome.
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