Journal ArticleDOI
The core promoter: At the heart of gene expression.
TLDR
A broad spectrum of studies that highlight the importance of the core promoter and its pivotal role in the regulation of metazoan gene expression are reviewed and future research directions and challenges are suggested.About:
This article is published in Biochimica et Biophysica Acta.The article was published on 2015-08-01. It has received 140 citations till now. The article focuses on the topics: Enhancer RNAs & Transcription factor II D.read more
Citations
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Journal ArticleDOI
Detoxification and antioxidant functions and regulatory mechanisms of two Delta-class GSTs in paddy crayfish (Procambarus clarkii) after imidacloprid stress.
TL;DR: In this article , two Delta-class Glutathione S-transferases (GSTs) cDNA sequences were cloned from Procambarus clarkii (PCGSTD1 and PcGSTD2).
Journal ArticleDOI
Functional identification and evolutionary conservation of the yme1L1 mitochondrial integrity gene promoter
TL;DR: Bioinformatics analyses allowed for the identification of the mouse yme1L1 promoter, several conserved and potentially important transcription factor binding sites, the promoter as a CpG island, and confirmation of evolutionary conservation among ten orthologous species promoter regions.
Posted ContentDOI
Androgen-dmrt1 positive feedback programs the rice field eel (Monopterus albus) sex transdifferentiation
TL;DR: Overall, androgen-dmrt1 positive feedback programs the M. albus sex reversal, leading to the promotion of dmrt1 transcription, and thus, gonadal somatic cells transdifferetiation.
Journal ArticleDOI
Effect of functional single nucleotide polymorphism g.-572 A > G of apolipoprotein A1 gene on resistance to ketosis in Chinese Holstein cows.
Ling Yang,Jiachen Bai,Zhihua Ju,Qiang Jiang,Jinpeng Wang,Gao Yaping,Zhang Yaran,Wei Xiaochao,Jinming Huang +8 more
TL;DR: It is reported for the first time that the genetic variant g.-572 A > G in the core promoter region of APOA1 gene was associated with the ketosis in Chinese Holstein cows, and g-572 A->-G may be used as a genetic marker for ketosis prevention.
Posted ContentDOI
Intron-driven gene expression in the absence of a core promoter in Arabidopsis thaliana
Jenna E. Gallegos,Alan B. Rose +1 more
TL;DR: The results suggest that certain introns play unexpectedly large roles in directing transcription initiation and represent a previously unrecognized type of downstream regulatory elements for genes transcribed by RNA polymerase II.
References
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Journal ArticleDOI
RNA-Seq: a revolutionary tool for transcriptomics
TL;DR: The RNA-Seq approach to transcriptome profiling that uses deep-sequencing technologies provides a far more precise measurement of levels of transcripts and their isoforms than other methods.
Journal ArticleDOI
Rapid production of full-length cDNAs from rare transcripts: amplification using a single gene-specific oligonucleotide primer
TL;DR: The efficacy of this cDNA cloning strategy was demonstrated by isolating cDNA clones of mRNA from int-2, a mouse gene that expresses four different transcripts at low abundance, the longest of which is approximately 2.9 kilobases.
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The Role of Chromatin during Transcription
TL;DR: This Review highlights advances in the understanding of chromatin regulation and discusses how such regulation affects the binding of transcription factors as well as the initiation and elongation steps of transcription.
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The mechanism of eukaryotic translation initiation and principles of its regulation
TL;DR: This work has provided a solid foundation for studying the regulation of translation initiation by mechanisms that include the modulation of initiation factor activity and through sequence-specific RNA-binding proteins and microRNAs (which affect individual mRNAs).
Journal ArticleDOI
RNA Maps Reveal New RNA Classes and a Possible Function for Pervasive Transcription
Philipp Kapranov,Jill Cheng,Sujit Dike,David A. Nix,Radharani Duttagupta,Aarron T. Willingham,Peter F. Stadler,Jana Hertel,Jörg Hackermüller,Ivo L. Hofacker,Ian Bell,Evelyn Cheung,Jorg Drenkow,Erica Dumais,Sandeep Patel,Gregg Helt,Madhavan Ganesh,Srinka Ghosh,Antonio Piccolboni,Victor Sementchenko,Hari Tammana,Thomas R. Gingeras +21 more
TL;DR: Three potentially functional classes of RNAs have been identified, two of which are syntenically conserved and correlate with the expression state of protein-coding genes and support a highly interleaved organization of the human transcriptome.
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