Journal ArticleDOI
The core promoter: At the heart of gene expression.
TLDR
A broad spectrum of studies that highlight the importance of the core promoter and its pivotal role in the regulation of metazoan gene expression are reviewed and future research directions and challenges are suggested.About:
This article is published in Biochimica et Biophysica Acta.The article was published on 2015-08-01. It has received 140 citations till now. The article focuses on the topics: Enhancer RNAs & Transcription factor II D.read more
Citations
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Journal ArticleDOI
The RNA Polymerase II Core Promoter in Drosophila
TL;DR: The properties of the RNA polymerase II core promoter in Drosophila indicate that the core promoter is a central component of the transcriptional apparatus that regulates gene expression.
Journal ArticleDOI
DNA structural features of eukaryotic TATA-containing and TATA-less promoters.
TL;DR: Characteristic differences in promoter sequences and associated structural properties of the two categories of genes in six different eukaryotes are reported, revealing that while the two classes of gene promoters are distinctly different from each other, the properties are also distinguishable across the six organisms.
Journal ArticleDOI
Adeno-Associated Virus Serotype-Specific Inverted Terminal Repeat Sequence Role in Vector Transgene Expression
Lauriel F. Earley,Laura Conatser,Victoria M. Lue,Amanda Lee Dobbins,Chengwen Li,Matthew L. Hirsch,R. Jude Samulski +6 more
TL;DR: The collective results demonstrate that the serotype ITR sequence may have multiple levels of influences on transgene expression cassettes independent of promoter selection.
Journal ArticleDOI
Enhancer Sharing Promotes Neighborhoods of Transcriptional Regulation Across Eukaryotes.
TL;DR: Cross-organismic evidence is presented suggesting that most EP pairs are compatible, largely determined by physical proximity rather than specific interactions, and that EP distance is an important layer of information in gene regulation.
Journal ArticleDOI
Interferons Induce Expression of SAMHD1 in Monocytes through Down-regulation of miR-181a and miR-30a.
Maximilian Riess,Nina V. Fuchs,Adam Idica,Matthias Hamdorf,Egbert Flory,Irene M. Pedersen,Renate König +6 more
TL;DR: It is suggested that SAMHD1 is a non-classical interferon-stimulated gene regulated through cell type-dependent down-regulation of miR-181a andMiR-30a in innate sentinel cells.
References
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Journal ArticleDOI
RNA-Seq: a revolutionary tool for transcriptomics
TL;DR: The RNA-Seq approach to transcriptome profiling that uses deep-sequencing technologies provides a far more precise measurement of levels of transcripts and their isoforms than other methods.
Journal ArticleDOI
Rapid production of full-length cDNAs from rare transcripts: amplification using a single gene-specific oligonucleotide primer
TL;DR: The efficacy of this cDNA cloning strategy was demonstrated by isolating cDNA clones of mRNA from int-2, a mouse gene that expresses four different transcripts at low abundance, the longest of which is approximately 2.9 kilobases.
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The Role of Chromatin during Transcription
TL;DR: This Review highlights advances in the understanding of chromatin regulation and discusses how such regulation affects the binding of transcription factors as well as the initiation and elongation steps of transcription.
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The mechanism of eukaryotic translation initiation and principles of its regulation
TL;DR: This work has provided a solid foundation for studying the regulation of translation initiation by mechanisms that include the modulation of initiation factor activity and through sequence-specific RNA-binding proteins and microRNAs (which affect individual mRNAs).
Journal ArticleDOI
RNA Maps Reveal New RNA Classes and a Possible Function for Pervasive Transcription
Philipp Kapranov,Jill Cheng,Sujit Dike,David A. Nix,Radharani Duttagupta,Aarron T. Willingham,Peter F. Stadler,Jana Hertel,Jörg Hackermüller,Ivo L. Hofacker,Ian Bell,Evelyn Cheung,Jorg Drenkow,Erica Dumais,Sandeep Patel,Gregg Helt,Madhavan Ganesh,Srinka Ghosh,Antonio Piccolboni,Victor Sementchenko,Hari Tammana,Thomas R. Gingeras +21 more
TL;DR: Three potentially functional classes of RNAs have been identified, two of which are syntenically conserved and correlate with the expression state of protein-coding genes and support a highly interleaved organization of the human transcriptome.
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