The Cytokines of Asthma
Reads0
Chats0
TLDR
The cytokine networks driving asthma are reviewed, placing these in cellular context and incorporating insights from cytokine-targeting therapies in the clinic, to argue that the development of new and improved therapeutics will require understanding the diverse mechanisms underlying the spectrum of asthma pathologies.About:
This article is published in Immunity.The article was published on 2019-04-16 and is currently open access. It has received 501 citations till now. The article focuses on the topics: Bronchial hyperresponsiveness & Systemic inflammation.read more
Citations
More filters
Journal ArticleDOI
Fungal Aeroallergens—The Impact of Climate Change
TL;DR: In this paper , the role of fungi as causative agents in the development of various overreactivity-related diseases, mainly affecting the respiratory tract, is reviewed, and the basic information on the mechanisms of allergic reactions is described.
Journal ArticleDOI
[The impact of specialized management on allergic asthma outcomes].
N. Marcozzi,Angelica Tiotiu +1 more
TL;DR: In this paper , a retrospective study including allergic asthmatic adults conducted between 1/01/2016 and 31/12/2018 was conducted to characterize allergic asthma in patients followed at the Nancy University Hospital.
Journal ArticleDOI
Integrated Mechanisms of Polarity–Based Extracts of Cucumis melo L. Seed Kernels for Airway Smooth Muscle Relaxation via Key Signaling Pathways Based on WGCNA, In Vivo, and In Vitro Analyses
Muqeet Wahid,Fatima Saqib,Anam Ali,Abdulrahman Alshammari,Metab Alharbi,Abdur Rauf,Mohammad S. Mubarak +6 more
TL;DR: In this paper , the mechanisms responsible for calcium-mediated smooth muscle contraction in C. melo seeds were determined with the aid of Liquid Chromatography Electrospray Ionization Tandem Mass Spectrometric (LC/ESI-MS/MS) and high performance liquid chromatography (HPLC).
Journal ArticleDOI
Lung dopaminergic nerves facilitate the establishment of TH2 resident memory cells in early life
Peifang Wang,Simon Porcher +1 more
TL;DR: In this article , the authors identify nerve-derived signals that act in TH2 effector cells to regulate the tissue residency in the immature lung following early life allergen exposure and demonstrate that maturing sympathetic nerves enable a dopamine-enriched lung environment in early life that promotes the establishment of TH2-TRMs.
References
More filters
Journal ArticleDOI
Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease
Paul M. Ridker,Brendan M. Everett,Tom Thuren,Jean G. MacFadyen,William Chang,Christie M. Ballantyne,Francisco H. Fonseca,Jose C. Nicolau,Wolfgang Koenig,Stefan D. Anker,John J.P. Kastelein,Jan H. Cornel,Prem Pais,Daniel Pella,Jacques Genest,Renata Cifkova,Alberto J. Lorenzatti,Tamás Forster,Zhanna Kobalava,Luminita Vida-Simiti,Marcus Flather,Hiroaki Shimokawa,Hisao Ogawa,Mikael Dellborg,Paulo Roberto Ferreira Rossi,Roland P.T. Troquay,Peter Libby,Robert J. Glynn +27 more
TL;DR: Antiinflammatory therapy targeting the interleukin‐1β innate immunity pathway with canakinumab at a dose of 150 mg every 3 months led to a significantly lower rate of recurrent cardiovascular events than placebo, independent of lipid‐level lowering.
Journal ArticleDOI
Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma
Douglas S. Robinson,Qutayba Hamid,Sun Ying,Anne Tsicopoulos,J. Barkans,Andrew Bentley,Christopher Corrigan,Stephen R. Durham,A. B. Kay +8 more
TL;DR: Atopic asthma is associated with activation in the bronchi of the interleukin-3, 4, and 5 and GM-CSF gene cluster, a pattern compatible with predominant activation of the TH2-like T-cell population.
Journal ArticleDOI
Interleukin-13: Central Mediator of Allergic Asthma
Marsha Wills-Karp,Jackie Luyimbazi,Xueying Xu,Brian Schofield,Tamlyn Neben,Christopher L. Karp,Debra D. Donaldson +6 more
TL;DR: In this paper, the type 2 cytokine IL-13, which shares a receptor component and signaling pathways with IL-4, was found to be necessary and sufficient for the expression of allergic asthma.
Journal ArticleDOI
Eosinophilic inflammation in asthma.
Jean Bousquet,Pascal Chanez,J.-Y. Lacoste,G. Barneon,N Ghavanian,I. Enander,Per Venge,Staffan Ahlstedt,J Simony-Lafontaine,P. Godard +9 more
TL;DR: Eosinophilic inflammation of the airways is correlated with the severity of asthma and these cells are likely to play a part in the epithelial damage seen in this disease.
Journal Article
Interleukin-13: Central mediator of allergic asthma
Marsha Wills-Karp,Jackie Luyimbazi,Xueying Xu,Brian Schofield,Tamlyn Neben,Christopher L. Karp,Debra D. Donaldson +6 more
TL;DR: In this article, the type 2 cytokine IL-13, which shares a receptor component and signaling pathways with IL-4, was found to be necessary and sufficient for the expression of allergic asthma.
Related Papers (5)
Dupilumab Efficacy and Safety in Moderate-to-Severe Uncontrolled Asthma
Mario Castro,Jonathan Corren,Ian D. Pavord,Jorge Maspero,Sally E. Wenzel,Klaus F. Rabe,William W. Busse,Linda B. Ford,Lawrence Sher,J. Mark FitzGerald,Constance H. Katelaris,Yuji Tohda,Bingzhi Zhang,Heribert Staudinger,Gianluca Pirozzi,Nikhil Amin,Marcella Ruddy,Bolanle Akinlade,Asif Khan,Jingdong Chao,Renata Martincova,Neil M.H. Graham,Jennifer D. Hamilton,Brian N. Swanson,Neil Stahl,George D. Yancopoulos,Ariel Teper +26 more