The Cytokines of Asthma
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TLDR
The cytokine networks driving asthma are reviewed, placing these in cellular context and incorporating insights from cytokine-targeting therapies in the clinic, to argue that the development of new and improved therapeutics will require understanding the diverse mechanisms underlying the spectrum of asthma pathologies.About:
This article is published in Immunity.The article was published on 2019-04-16 and is currently open access. It has received 501 citations till now. The article focuses on the topics: Bronchial hyperresponsiveness & Systemic inflammation.read more
Citations
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Does the epithelial barrier hypothesis explain the increase in allergy, autoimmunity and other chronic conditions?
TL;DR: Akdis et al. as discussed by the authors introduced an extended "epithelial barrier hypothesis" which proposes that the increase in epithelial barrier-damaging agents linked to industrialization, urbanization and modern life underlies the rise in allergic, autoimmune and other chronic conditions.
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The basic immunology of asthma
Hamida Hammad,Bart N. Lambrecht +1 more
TL;DR: In this article, the underlying immunological basis of various asthma endotypes by discussing results obtained from animal studies as well as results generated in clinical studies targeting specific immune pathways is discussed.
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The cytokine network involved in the host immune response to periodontitis
TL;DR: This review begins with an up-to-date aetiological hypothesis of periodontal disease and summarize the roles of cytokines in the host immune response and the latest cytokine-related therapeutic measures for periodontic disease.
Journal ArticleDOI
Type 2 immunity in the skin and lungs.
Cezmi A. Akdis,Peter D. Arkwright,Marie-Charlotte Brüggen,William W. Busse,Massimo Gadina,Emma Guttman-Yassky,Emma Guttman-Yassky,Kenji Kabashima,Kenji Kabashima,Yasutaka Mitamura,Laura Vian,Jianni Wu,Jianni Wu,Oscar Palomares +13 more
TL;DR: The present review aims to highlight recent advances in type 2 immunity and discuss the cellular sources, targets, and roles of type 2 mechanisms in asthma and AD.
Posted ContentDOI
FinnGen: Unique genetic insights from combining isolated population and national health register data
Mitja I. Kurki,Juha Karjalainen,Priit Palta,T. P. Sipilampauml,Kati Kristiansson,Kati Donner,Mary Pat Reeve,Hannele Laivuori,Mervi Aavikko,Mari A. Kaunisto,Anu Loukola,Elisa Lahtela,Hannele Mattsson,Päivi Laiho,P. della Briotta Parolo,Arto Lehisto,Masahiro Kanai,Nina Mars,J. RaÌmoÌ,Tuomo Kiiskinen,Henrike O. Heyne,Kumar Veerapen,S. RuÌeger,S. LemmelaÌ,W. Zhou,Sanni Ruotsalainen,K. PaÌrn,Tero Hiekkalinna,Sami Koskelainen,Tuula A. Paajanen,Victor Llorens,Javier Gracia-Tabuenca,Harri Siirtola,Katherine Reis,Adel Elnahas,K. Aalto-SetaÌlaÌ,Kaur Alasoo,Muhammed Ikbal Arvas,Kirsi Auro,Shrayashi Biswas,A. Bizaki-Vallaskangas +40 more
TL;DR: The power of bottlenecked populations to find unique entry points into the biology of common diseases through low-frequency, high impact variants is demonstrated.
References
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Journal ArticleDOI
In vivo blockade of OX40 ligand inhibits thymic stromal lymphopoietin driven atopic inflammation
Dhaya Seshasayee,Wyne P. Lee,Meijuan Zhou,Jean Shu,Eric Suto,Juan Zhang,Laurie Diehl,Cary D. Austin,Y. Gloria Meng,Martha Tan,Sherron Bullens,Stefan Seeber,Maria E. Fuentes,Aran F. Labrijn,Yvo Graus,Lisa A. Miller,Edward S. Schelegle,Dallas M. Hyde,Lawren C. Wu,Sarah G. Hymowitz,Sarah G. Hymowitz,Flavius Martin +21 more
TL;DR: It is shown that OX40 ligand (OX40L) is a critical in vivo mediator of TSLP-mediated Th2 responses and presents a promising strategy for the treatment of allergic diseases associated with pathologic Th2 immune responses.
Journal ArticleDOI
Involvement of il-5 in a murine model of allergic pulmonary inflammation :prophylactic and therapeutic effect of an anti-il-5 antibody
Ted T. Kung,D. Stelts,J. A. Zurcher,G K Adams,Robert W. Egan,William Kreutner,Arthur S. Watnick,Howard Jones,Richard W. Chapman +8 more
TL;DR: An important role for IL-5 is demonstrated in the development of eosinophilic inflammation of the airways and for the migration of eOSinophils from the bone marrow into blood in response to antigen challenge.
Journal ArticleDOI
Steroid resistance of airway type 2 innate lymphoid cells from patients with severe asthma: The role of thymic stromal lymphopoietin.
Sucai Liu,Mukesh Verma,Lidia Michalec,Weimin Liu,Anand Sripada,Donald Rollins,James T. Good,Yoko Ito,HongWei Chu,Magdalena M. Gorska,Richard J. Martin,Rafeul Alam +11 more
TL;DR: IL‐7 and TSLP abrogated this inhibition and induced steroid resistance of ILC2s in a MEK‐ and STAT5‐dependent manner, which was reversed by clinically available inhibitors of MEK andSTAT5.
Journal ArticleDOI
IL-9 governs allergen-induced mast cell numbers in the lung and chronic remodeling of the airways.
Jennifer Kearley,Jonas S. Erjefält,Cecilia Andersson,Ebony Benjamin,Carla P. Jones,Annette Robichaud,Sophie Pegorier,Yambasu A. Brewah,Timothy Burwell,Leif Bjermer,Peter A. Kiener,Roland Kolbeck,Clare M. Lloyd,Anthony J. Coyle,Alison A. Humbles +14 more
TL;DR: The data suggest an important role for an IL-9-MC axis in the pathology associated with chronic asthma and demonstrate that an impact on this axis could lead to a reduction in chronic inflammation and improved lung function in patients with asthma.
Journal ArticleDOI
Th17 responses in chronic allergic airway inflammation abrogate regulatory T-cell-mediated tolerance and contribute to airway remodeling
TL;DR: It is demonstrated that both parenteral and mucosalAllergen sensitization, followed by allergen inhalation, leads to Th17-biased lung immune responses, and targeting the Th17/Treg axis might therefore be therapeutic in neutrophilic and glucocorticoid-refractory asthma.
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