The Cytokines of Asthma
Reads0
Chats0
TLDR
The cytokine networks driving asthma are reviewed, placing these in cellular context and incorporating insights from cytokine-targeting therapies in the clinic, to argue that the development of new and improved therapeutics will require understanding the diverse mechanisms underlying the spectrum of asthma pathologies.About:
This article is published in Immunity.The article was published on 2019-04-16 and is currently open access. It has received 501 citations till now. The article focuses on the topics: Bronchial hyperresponsiveness & Systemic inflammation.read more
Citations
More filters
Journal ArticleDOI
Does the epithelial barrier hypothesis explain the increase in allergy, autoimmunity and other chronic conditions?
TL;DR: Akdis et al. as discussed by the authors introduced an extended "epithelial barrier hypothesis" which proposes that the increase in epithelial barrier-damaging agents linked to industrialization, urbanization and modern life underlies the rise in allergic, autoimmune and other chronic conditions.
Journal ArticleDOI
The basic immunology of asthma
Hamida Hammad,Bart N. Lambrecht +1 more
TL;DR: In this article, the underlying immunological basis of various asthma endotypes by discussing results obtained from animal studies as well as results generated in clinical studies targeting specific immune pathways is discussed.
Journal ArticleDOI
The cytokine network involved in the host immune response to periodontitis
TL;DR: This review begins with an up-to-date aetiological hypothesis of periodontal disease and summarize the roles of cytokines in the host immune response and the latest cytokine-related therapeutic measures for periodontic disease.
Journal ArticleDOI
Type 2 immunity in the skin and lungs.
Cezmi A. Akdis,Peter D. Arkwright,Marie-Charlotte Brüggen,William W. Busse,Massimo Gadina,Emma Guttman-Yassky,Emma Guttman-Yassky,Kenji Kabashima,Kenji Kabashima,Yasutaka Mitamura,Laura Vian,Jianni Wu,Jianni Wu,Oscar Palomares +13 more
TL;DR: The present review aims to highlight recent advances in type 2 immunity and discuss the cellular sources, targets, and roles of type 2 mechanisms in asthma and AD.
Posted ContentDOI
FinnGen: Unique genetic insights from combining isolated population and national health register data
Mitja I. Kurki,Juha Karjalainen,Priit Palta,T. P. Sipilampauml,Kati Kristiansson,Kati Donner,Mary Pat Reeve,Hannele Laivuori,Mervi Aavikko,Mari A. Kaunisto,Anu Loukola,Elisa Lahtela,Hannele Mattsson,Päivi Laiho,P. della Briotta Parolo,Arto Lehisto,Masahiro Kanai,Nina Mars,J. RaÌmoÌ,Tuomo Kiiskinen,Henrike O. Heyne,Kumar Veerapen,S. RuÌeger,S. LemmelaÌ,W. Zhou,Sanni Ruotsalainen,K. PaÌrn,Tero Hiekkalinna,Sami Koskelainen,Tuula A. Paajanen,Victor Llorens,Javier Gracia-Tabuenca,Harri Siirtola,Katherine Reis,Adel Elnahas,K. Aalto-SetaÌlaÌ,Kaur Alasoo,Muhammed Ikbal Arvas,Kirsi Auro,Shrayashi Biswas,A. Bizaki-Vallaskangas +40 more
TL;DR: The power of bottlenecked populations to find unique entry points into the biology of common diseases through low-frequency, high impact variants is demonstrated.
References
More filters
Journal ArticleDOI
An Unexpected Role for Uric Acid as an Inducer of T Helper 2 Cell Immunity to Inhaled Antigens and Inflammatory Mediator of Allergic Asthma
Mirjam Kool,Monique Willart,Menno van Nimwegen,Ingrid M. Bergen,Philippe Pouliot,J. Christian Virchow,Neil C. Rogers,Fabiola Osorio,Caetano Reis e Sousa,Hamida Hammad,Bart N. Lambrecht,Bart N. Lambrecht +11 more
TL;DR: It is shown that UA is released in the airways of allergen-challenged asthmatic patients and mice, where it was necessary for mounting T helper 2 (Th2) cell immunity, airway eosinophilia, and bronchial hyperreactivity to inhaled harmless proteins and clinically relevant house dust mite allerGEN.
Journal ArticleDOI
Allergen-induced airway inflammation and bronchial responsiveness in wild-type and interleukin-4-deficient mice
TL;DR: It is indicated that repeated allergen exposure in sensitized mice induces airway inflammation and bronchial hyperresponsiveness, and that IL-4 plays a predominant role in the pathogenesis of both phenomena.
Journal ArticleDOI
Inflammatory triggers associated with exacerbations of COPD orchestrate plasticity of group 2 innate lymphoid cells in the lungs
Jonathan S. Silver,Jennifer Kearley,Alan M. Copenhaver,Caroline Sanden,Michiko Mori,Li Yu,Gretchen Harms Pritchard,Aaron A Berlin,Christopher A. Hunter,Russell P. Bowler,Jonas S. Erjefält,Roland Kolbeck,Alison A. Humbles +12 more
TL;DR: Functional plasticity of ILC2 cells exacerbates anti-viral immunity, which may have adverse consequences in respiratory diseases such as COPD.
Journal ArticleDOI
Phase 3 Study of Reslizumab in Patients With Poorly Controlled Asthma: Effects Across a Broad Range of Eosinophil Counts
TL;DR: Rlizumab was well tolerated in patients with inadequately controlled asthma, with fewer overall adverse events compared with placebo and Clinically meaningful effects on lung function and symptom control were not seen in patients unselected for baseline eosinophils.
Journal ArticleDOI
A Randomized, Controlled, Phase 2 Study of AMG 317, an IL-4Rα Antagonist, in Patients with Asthma
Jonathan Corren,William W. Busse,Eli O. Meltzer,Lyndon E. Mansfield,George W. Bensch,John Fahrenholz,Sally E. Wenzel,Yun Chon,Meleana Dunn,Haoling H. Weng,Shao-Lee Lin +10 more
TL;DR: Clinically significant improvements were observed in several outcome measures in patients with higher baseline ACQ scores, and AMG 317 did not demonstrate clinical efficacy across the overall group of patients.
Related Papers (5)
Dupilumab Efficacy and Safety in Moderate-to-Severe Uncontrolled Asthma
Mario Castro,Jonathan Corren,Ian D. Pavord,Jorge Maspero,Sally E. Wenzel,Klaus F. Rabe,William W. Busse,Linda B. Ford,Lawrence Sher,J. Mark FitzGerald,Constance H. Katelaris,Yuji Tohda,Bingzhi Zhang,Heribert Staudinger,Gianluca Pirozzi,Nikhil Amin,Marcella Ruddy,Bolanle Akinlade,Asif Khan,Jingdong Chao,Renata Martincova,Neil M.H. Graham,Jennifer D. Hamilton,Brian N. Swanson,Neil Stahl,George D. Yancopoulos,Ariel Teper +26 more