The Cytokines of Asthma
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TLDR
The cytokine networks driving asthma are reviewed, placing these in cellular context and incorporating insights from cytokine-targeting therapies in the clinic, to argue that the development of new and improved therapeutics will require understanding the diverse mechanisms underlying the spectrum of asthma pathologies.About:
This article is published in Immunity.The article was published on 2019-04-16 and is currently open access. It has received 501 citations till now. The article focuses on the topics: Bronchial hyperresponsiveness & Systemic inflammation.read more
Citations
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Does the epithelial barrier hypothesis explain the increase in allergy, autoimmunity and other chronic conditions?
TL;DR: Akdis et al. as discussed by the authors introduced an extended "epithelial barrier hypothesis" which proposes that the increase in epithelial barrier-damaging agents linked to industrialization, urbanization and modern life underlies the rise in allergic, autoimmune and other chronic conditions.
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The basic immunology of asthma
Hamida Hammad,Bart N. Lambrecht +1 more
TL;DR: In this article, the underlying immunological basis of various asthma endotypes by discussing results obtained from animal studies as well as results generated in clinical studies targeting specific immune pathways is discussed.
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The cytokine network involved in the host immune response to periodontitis
TL;DR: This review begins with an up-to-date aetiological hypothesis of periodontal disease and summarize the roles of cytokines in the host immune response and the latest cytokine-related therapeutic measures for periodontic disease.
Journal ArticleDOI
Type 2 immunity in the skin and lungs.
Cezmi A. Akdis,Peter D. Arkwright,Marie-Charlotte Brüggen,William W. Busse,Massimo Gadina,Emma Guttman-Yassky,Emma Guttman-Yassky,Kenji Kabashima,Kenji Kabashima,Yasutaka Mitamura,Laura Vian,Jianni Wu,Jianni Wu,Oscar Palomares +13 more
TL;DR: The present review aims to highlight recent advances in type 2 immunity and discuss the cellular sources, targets, and roles of type 2 mechanisms in asthma and AD.
Posted ContentDOI
FinnGen: Unique genetic insights from combining isolated population and national health register data
Mitja I. Kurki,Juha Karjalainen,Priit Palta,T. P. Sipilampauml,Kati Kristiansson,Kati Donner,Mary Pat Reeve,Hannele Laivuori,Mervi Aavikko,Mari A. Kaunisto,Anu Loukola,Elisa Lahtela,Hannele Mattsson,Päivi Laiho,P. della Briotta Parolo,Arto Lehisto,Masahiro Kanai,Nina Mars,J. RaÌmoÌ,Tuomo Kiiskinen,Henrike O. Heyne,Kumar Veerapen,S. RuÌeger,S. LemmelaÌ,W. Zhou,Sanni Ruotsalainen,K. PaÌrn,Tero Hiekkalinna,Sami Koskelainen,Tuula A. Paajanen,Victor Llorens,Javier Gracia-Tabuenca,Harri Siirtola,Katherine Reis,Adel Elnahas,K. Aalto-SetaÌlaÌ,Kaur Alasoo,Muhammed Ikbal Arvas,Kirsi Auro,Shrayashi Biswas,A. Bizaki-Vallaskangas +40 more
TL;DR: The power of bottlenecked populations to find unique entry points into the biology of common diseases through low-frequency, high impact variants is demonstrated.
References
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Pulmonary neuroendocrine cells amplify allergic asthma responses
Pengfei Sui,Pengfei Sui,Darin L. Wiesner,Jinhao Xu,Jinhao Xu,Yan Zhang,Yan Zhang,Jinwoo Lee,Steven J. Van Dyken,Amber J. Lashua,Chuyue Yu,Bruce S. Klein,Richard M. Locksley,Gail H. Deutsch,Xin Sun,Xin Sun +15 more
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Environmental allergens induce allergic inflammation through proteolytic maturation of IL-33
Corinne Cayrol,Anais Duval,Pauline Schmitt,Stéphane Roga,Mylène Camus,Alexandre Stella,Odile Burlet-Schiltz,Anne Gonzalez-de-Peredo,Jean-Philippe Girard +8 more
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Increased frequency of dual-positive TH2/TH17 cells in bronchoalveolar lavage fluid characterizes a population of patients with severe asthma.
Chaoyu Irvin,Iram Zafar,James T. Good,Donald Rollins,Christina A. Christianson,Magdalena M. Gorska,Richard J. Martin,Rafeul Alam +7 more
TL;DR: Asthma is associated with a higher frequency of dual-positive TH2/TH17 cells in BAL fluid, and the TH2-predominant subgroup manifested the most severe form of asthma, whereas the TH-2-TH17(low) subgroup had the mildest asthma.
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Interleukin-2-Dependent Allergen-Specific Tissue-Resident Memory Cells Drive Asthma
Brian D. Hondowicz,Dowon An,Jason M. Schenkel,Karen S. Kim,Holly R. Steach,Akshay T. Krishnamurty,Gladys J. Keitany,Esteban N. Garza,Kathryn A. Fraser,James J. Moon,William A. Altemeier,David Masopust,Marion Pepper +12 more
TL;DR: Investigation into the differentiation of pathogenic Trm cells revealed that interleukin-2 (IL-2) signaling was required for residency and directed a program of tissue homing migrational cues that identified IL-2-dependent resident Th2 memory cells as drivers of lung allergic responses.
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Chitin activates parallel immune modules that direct distinct inflammatory responses via innate lymphoid type 2 and γδ T cells.
Steven J. Van Dyken,Alexander Mohapatra,Jesse C. Nussbaum,Ari B. Molofsky,Emily E. Thornton,Steven F. Ziegler,Andrew N. J. McKenzie,Matthew F. Krummel,Hong-Erh Liang,Richard M. Locksley +9 more
TL;DR: Inhaled chitin elicited patterns of innate cytokines that targeted distinct populations of resident lymphoid cells, revealing divergent but interacting pathways underlying the tissue accumulation of specific types of inflammatory myeloid cells.
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