The Cytokines of Asthma
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TLDR
The cytokine networks driving asthma are reviewed, placing these in cellular context and incorporating insights from cytokine-targeting therapies in the clinic, to argue that the development of new and improved therapeutics will require understanding the diverse mechanisms underlying the spectrum of asthma pathologies.About:
This article is published in Immunity.The article was published on 2019-04-16 and is currently open access. It has received 501 citations till now. The article focuses on the topics: Bronchial hyperresponsiveness & Systemic inflammation.read more
Citations
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Eosinophils: Cells known for over 140 years with broad and new functions.
TL;DR: The molecular mechanisms underlying the development of eosinophils and the various functions of granules, including CLCs, during eosInophilic inflammation are reviewed and the double-edged roles of eOSinophil in tissue repair and type 2 immune inflammation are discussed.
Journal ArticleDOI
Real-Life effects of benralizumab on exacerbation number and lung hyperinflation in atopic patients with severe eosinophilic asthma.
Corrado Pelaia,Maria Teresa Busceti,Claudia Crimi,Giovanna Elisiana Carpagnano,Nicola Lombardo,Rosa Terracciano,Alessandro Vatrella,Girolamo Pelaia +7 more
TL;DR: The results suggest that via its anti-eosinophil actions benralizumab improved airflow limitation, lung hyperinflation, and respiratory symptoms, as well as lowered asthma exacerbation rate and abrogated OCS consumption in most patients.
Journal ArticleDOI
Pyruvate Kinase M2 Promotes Expression of Proinflammatory Mediators in House Dust Mite-Induced Allergic Airways Disease.
Cheryl van de Wetering,Cheryl van de Wetering,Reem Aboushousha,Allison M. Manuel,Shi B. Chia,Cuixia Erickson,Maximilian B. MacPherson,Jos van der Velden,Vikas Anathy,Anne E. Dixon,Charles G. Irvin,Matthew E. Poynter,Albert van der Vliet,Emiel F.M. Wouters,Niki L. Reynaert,Yvonne M. W. Janssen-Heininger +15 more
TL;DR: In this article, the authors examined the impact of pyruvate kinase M2 on the pathogenesis of house dust mite-induced allergic airway disease in C57BL/6NJ mice.
Journal ArticleDOI
Resolution of allergic asthma
TL;DR: Novel insights are considered into the immunopathogenesis of asthma and the protective and pathogenic roles of some innate and adaptive immune cells as well as the function of soluble mediators such as cytokines.
Journal ArticleDOI
Sesamol alleviates airway hyperresponsiveness and oxidative stress in asthmatic mice
Chian-Jiun Liou,Chian-Jiun Liou,Ya Ling Chen,Ming Chin Yu,Kuo Wei Yeh,Szu Chuan Shen,Wen Chung Huang,Wen Chung Huang +7 more
TL;DR: It is demonstrated that sesamol showed potential as a therapeutic agent for improving asthma by suppressing eosinophil infiltration in the lung, airway hyperresponsiveness, and T helper 2 cell-associated (Th2) cytokine expressions in bronchoalveolar lavage fluid and the lungs.
References
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Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease
Paul M. Ridker,Brendan M. Everett,Tom Thuren,Jean G. MacFadyen,William Chang,Christie M. Ballantyne,Francisco H. Fonseca,Jose C. Nicolau,Wolfgang Koenig,Stefan D. Anker,John J.P. Kastelein,Jan H. Cornel,Prem Pais,Daniel Pella,Jacques Genest,Renata Cifkova,Alberto J. Lorenzatti,Tamás Forster,Zhanna Kobalava,Luminita Vida-Simiti,Marcus Flather,Hiroaki Shimokawa,Hisao Ogawa,Mikael Dellborg,Paulo Roberto Ferreira Rossi,Roland P.T. Troquay,Peter Libby,Robert J. Glynn +27 more
TL;DR: Antiinflammatory therapy targeting the interleukin‐1β innate immunity pathway with canakinumab at a dose of 150 mg every 3 months led to a significantly lower rate of recurrent cardiovascular events than placebo, independent of lipid‐level lowering.
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Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma
Douglas S. Robinson,Qutayba Hamid,Sun Ying,Anne Tsicopoulos,J. Barkans,Andrew Bentley,Christopher Corrigan,Stephen R. Durham,A. B. Kay +8 more
TL;DR: Atopic asthma is associated with activation in the bronchi of the interleukin-3, 4, and 5 and GM-CSF gene cluster, a pattern compatible with predominant activation of the TH2-like T-cell population.
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Interleukin-13: Central Mediator of Allergic Asthma
Marsha Wills-Karp,Jackie Luyimbazi,Xueying Xu,Brian Schofield,Tamlyn Neben,Christopher L. Karp,Debra D. Donaldson +6 more
TL;DR: In this paper, the type 2 cytokine IL-13, which shares a receptor component and signaling pathways with IL-4, was found to be necessary and sufficient for the expression of allergic asthma.
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Eosinophilic inflammation in asthma.
Jean Bousquet,Pascal Chanez,J.-Y. Lacoste,G. Barneon,N Ghavanian,I. Enander,Per Venge,Staffan Ahlstedt,J Simony-Lafontaine,P. Godard +9 more
TL;DR: Eosinophilic inflammation of the airways is correlated with the severity of asthma and these cells are likely to play a part in the epithelial damage seen in this disease.
Journal Article
Interleukin-13: Central mediator of allergic asthma
Marsha Wills-Karp,Jackie Luyimbazi,Xueying Xu,Brian Schofield,Tamlyn Neben,Christopher L. Karp,Debra D. Donaldson +6 more
TL;DR: In this article, the type 2 cytokine IL-13, which shares a receptor component and signaling pathways with IL-4, was found to be necessary and sufficient for the expression of allergic asthma.
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