The Cytokines of Asthma
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TLDR
The cytokine networks driving asthma are reviewed, placing these in cellular context and incorporating insights from cytokine-targeting therapies in the clinic, to argue that the development of new and improved therapeutics will require understanding the diverse mechanisms underlying the spectrum of asthma pathologies.About:
This article is published in Immunity.The article was published on 2019-04-16 and is currently open access. It has received 501 citations till now. The article focuses on the topics: Bronchial hyperresponsiveness & Systemic inflammation.read more
Citations
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Omalizumab is effective in allergic and non-allergic patients with nasal polyps and asthma
Philippe Gevaert,Lien Calus,Thibaut Van Zele,Katrien Blomme,Natalie De Ruyck,Wouter Bauters,P Hellings,Dirk De Bacquer,Guy Brusselle,Paul Van Cauwenberge,Claus Bachert +10 more
TL;DR: Omalizumab is a human anti-IgE mAb with proved efficacy in patients with severe allergic asthma as mentioned in this paper, which could be a treatment option for patients with nasal polyps and asthma.
Journal ArticleDOI
CCR5 attenuates neutrophilic airway inflammation exacerbated by infection with rhinovirus
Ferdaus Mohd Altaf Hossain,Seong Ok Park,Hyo Jin Kim,Jun Cheol Eo,Jin Young Choi,Erdenebelig Uyangaa,Bumseok Kim,Koanhoi Kim,Seong Kug Eo +8 more
TL;DR: The results suggest that CCR5 attenuates hRV-induced neutrophilic airway inflammation through conserving the equilibrium of CD4+Foxp3+ Treg cells and IL-17+CD4+ Th17 cells in hRv-induced asthma exacerbation, along with suppressing Th2 responses.
Aspergillus fumigatus–Secreted Alkaline Protease 1 Mediates Airways Hyperresponsiveness in Severe Asthma
Jamie L Redes,Trisha Basu,Sumati Ram-Mohan,Chandra C. Ghosh,Eunice C. Chan,Albert C. Sek,Ming Zhao,Ramaswamy Krishnan,Helene F. Rosenberg,Kirk M. Druey +9 more
TL;DR: It is demonstrated that the serine protease Alp1 from the ubiquitous mold and allergen, Aspergillus fumigatus, can induce AHR in mice unable to generate eosinophilic inflammation and point to a new target for direct intervention of fungal-associated asthma.
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Dexmedetomidine alleviates airway hyperresponsiveness and allergic airway inflammation through the TLR4/NF-κB signaling pathway in mice
TL;DR: In the murine OVA-induced asthma model, DEX decreased AHR following Mch inhalation and reduced the infiltration of inflammatory cells, and it is suggested that DEX may represent a potential anti-inflammatory agent for the treatment and management of patients with asthma.
Journal ArticleDOI
A pathogenic integrated view explaining the different endotypes of asthma and allergic disorders
TL;DR: This review proposes some immunopathogenic scenarios characterizing the principal endotypes which can be associated with a precise phenotype of asthma, and indicates that similar concepts can also be applied to the inflammation of other non‐respiratory allergic disorders.
References
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Journal ArticleDOI
Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease
Paul M. Ridker,Brendan M. Everett,Tom Thuren,Jean G. MacFadyen,William Chang,Christie M. Ballantyne,Francisco H. Fonseca,Jose C. Nicolau,Wolfgang Koenig,Stefan D. Anker,John J.P. Kastelein,Jan H. Cornel,Prem Pais,Daniel Pella,Jacques Genest,Renata Cifkova,Alberto J. Lorenzatti,Tamás Forster,Zhanna Kobalava,Luminita Vida-Simiti,Marcus Flather,Hiroaki Shimokawa,Hisao Ogawa,Mikael Dellborg,Paulo Roberto Ferreira Rossi,Roland P.T. Troquay,Peter Libby,Robert J. Glynn +27 more
TL;DR: Antiinflammatory therapy targeting the interleukin‐1β innate immunity pathway with canakinumab at a dose of 150 mg every 3 months led to a significantly lower rate of recurrent cardiovascular events than placebo, independent of lipid‐level lowering.
Journal ArticleDOI
Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma
Douglas S. Robinson,Qutayba Hamid,Sun Ying,Anne Tsicopoulos,J. Barkans,Andrew Bentley,Christopher Corrigan,Stephen R. Durham,A. B. Kay +8 more
TL;DR: Atopic asthma is associated with activation in the bronchi of the interleukin-3, 4, and 5 and GM-CSF gene cluster, a pattern compatible with predominant activation of the TH2-like T-cell population.
Journal ArticleDOI
Interleukin-13: Central Mediator of Allergic Asthma
Marsha Wills-Karp,Jackie Luyimbazi,Xueying Xu,Brian Schofield,Tamlyn Neben,Christopher L. Karp,Debra D. Donaldson +6 more
TL;DR: In this paper, the type 2 cytokine IL-13, which shares a receptor component and signaling pathways with IL-4, was found to be necessary and sufficient for the expression of allergic asthma.
Journal ArticleDOI
Eosinophilic inflammation in asthma.
Jean Bousquet,Pascal Chanez,J.-Y. Lacoste,G. Barneon,N Ghavanian,I. Enander,Per Venge,Staffan Ahlstedt,J Simony-Lafontaine,P. Godard +9 more
TL;DR: Eosinophilic inflammation of the airways is correlated with the severity of asthma and these cells are likely to play a part in the epithelial damage seen in this disease.
Journal Article
Interleukin-13: Central mediator of allergic asthma
Marsha Wills-Karp,Jackie Luyimbazi,Xueying Xu,Brian Schofield,Tamlyn Neben,Christopher L. Karp,Debra D. Donaldson +6 more
TL;DR: In this article, the type 2 cytokine IL-13, which shares a receptor component and signaling pathways with IL-4, was found to be necessary and sufficient for the expression of allergic asthma.
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