The Feline Genome Project.
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TLDR
The advantages, rationale, and present strategy of a feline genome project are reviewed, and the disease models, comparative genomics, and biological applications posed by the full resolution of the cat's genome are described.Abstract:
The compilation of a dense gene map and eventually a whole genome sequence (WGS) of the domestic cat holds considerable value for human genome annotation, for veterinary medicine, and for insight into the evolution of genome organization among mammals. Human association and veterinary studies of the cat, its domestic breeds, and its charismatic wild relatives of the family Felidae have rendered the species a powerful model for human hereditary diseases, for infectious disease agents, for adaptive evolutionary divergence, for conservation genetics, and for forensic applications. Here we review the advantages, rationale, and present strategy of a feline genome project, and we describe the disease models, comparative genomics, and biological applications posed by the full resolution of the cat's genome.read more
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Journal ArticleDOI
Initial sequence and comparative analysis of the cat genome
Joan Pontius,James C. Mullikin,Douglas Smith,Agencourt Sequencing Team,Kerstin Lindblad-Toh,Sante Gnerre,Michele Clamp,Jean Chang,Robert M. Stephens,Beena Neelam,Natalia Volfovsky,Alejandro A. Schäffer,Richa Agarwala,Kristina Narfström,William J. Murphy,Urs Giger,Alfred L. Roca,Agostinho Antunes,Agostinho Antunes,Marilyn Menotti-Raymond,Naoya Yuhki,Jill Pecon-Slattery,Warren E. Johnson,Guillaume Bourque,Glenn Tesler,Nisc Comparative Sequencing Program,Stephen J. O'Brien +26 more
TL;DR: The genome sequence of an inbred Abyssinian domestic cat was assembled, mapped, and annotated with a comparative approach that involved cross-reference to annotated genome assemblies of six mammals, shedding new light on the tempo and mode of gene/genome evolution in mammals and promising several research applications for the cat.
Journal ArticleDOI
Functions, structure, and read-through alternative splicing of feline APOBEC3 genes
Carsten Münk,Thomas William Beck,Jörg Zielonka,Agnes Hotz-Wagenblatt,Sarah Chareza,Marion Battenberg,Jens Thielebein,Klaus Cichutek,Ignacio G. Bravo,Stephen J. O'Brien,Martin Löchelt,Naoya Yuhki +11 more
TL;DR: The data support a complex evolutionary history of expansion, divergence, selection and individual extinction of antiviral A3 genes that parallels the early evolution of Placentalia, becoming more intricate in taxa in which the arms race between host and retroviruses is harsher.
Journal ArticleDOI
The impact and potential etiology of teratospermia in the domestic cat and its wild relatives.
TL;DR: It now is clear that gain in sperm quantity is achieved at the expense of sperm quality, suggesting an extensive disruption of normal testicular function in teratospermic donors.
Journal ArticleDOI
Second-Generation Integrated Genetic Linkage/Radiation Hybrid Maps of the Domestic Cat (Felis catus)
Marilyn Menotti-Raymond,Victor A. David,Zhao-hong Chen,K. A. Menotti,Shouheng Sun,Alejandro A. Schäffer,Richa Agarwala,James F. Tomlin,Stephen J. O'Brien,William J. Murphy +9 more
TL;DR: The integrated linkage and RH maps reveal approximately 110 conserved segments ordered between the human and feline genomes, and provide extensive anchored reference marker homologues that connect to the more gene dense human and mouse sequence maps, suitable for positional cloning applications.
Journal Article
Spontaneous feline mammary carcinoma is a model of HER2 overexpressing poor prognosis human breast cancer.
Raffaella De Maria,Martina Olivero,Selina Iussich,Munekazu Nakaichi,Tomoaki Murata,Bartolomeo Biolatti,Maria Flavia Di Renzo +6 more
TL;DR: The identified and studied the feline orthologue of the HER2 gene, which is both an important prognostic marker and therapeutic target in human cancer, and showed that an anti-human HER2 antibody recognized a protein comigrating with the human p185HER2 in FMC cell lines.
References
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Initial sequencing and analysis of the human genome.
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TL;DR: The results of an international collaboration to produce and make freely available a draft sequence of the human genome are reported and an initial analysis is presented, describing some of the insights that can be gleaned from the sequence.
Book
The Metabolic and Molecular Bases of Inherited Disease
TL;DR: In this paper, the authors present a list of disorders of MITOCHONDRIAL FUNCTION, including the following: DISORDERS OF MIOCHONDRIC FERTILITY XIX, XVI, XIX.
Journal ArticleDOI
Dystrophin: The protein product of the duchenne muscular dystrophy locus
TL;DR: The identification of the mdx mouse as an animal model for DMD has important implications with regard to the etiology of the lethal DMD phenotype, and the protein dystrophin is named because of its identification via the isolation of the Duchenne muscular dystrophy locus.
Book
Introduction to Conservation Genetics
TL;DR: Using molecular genetics in forensics and to understand species biology, the broader context: Population Viability Analysis (PVA) is examined.
Journal ArticleDOI
The Complete Sequence of Dystrophin Predicts a Rod-Shaped Cytoskeletal Protein
M. Koenig,M. Koenig,Anthony P. Monaco,Anthony P. Monaco,Louis M. Kunkel,Louis M. Kunkel,Louis M. Kunkel +6 more
TL;DR: The complete sequence of the human Duchenne muscular dystrophy cDNA has been determined and dystrophin shares many features with the cytoskeletal protein spectrin and alpha-actinin and is likely to adopt a rod shape about 150 nm in length.
Related Papers (5)
Initial sequence and comparative analysis of the cat genome
Joan Pontius,James C. Mullikin,Douglas Smith,Agencourt Sequencing Team,Kerstin Lindblad-Toh,Sante Gnerre,Michele Clamp,Jean Chang,Robert M. Stephens,Beena Neelam,Natalia Volfovsky,Alejandro A. Schäffer,Richa Agarwala,Kristina Narfström,William J. Murphy,Urs Giger,Alfred L. Roca,Agostinho Antunes,Agostinho Antunes,Marilyn Menotti-Raymond,Naoya Yuhki,Jill Pecon-Slattery,Warren E. Johnson,Guillaume Bourque,Glenn Tesler,Nisc Comparative Sequencing Program,Stephen J. O'Brien +26 more