The Galα1,3Galβ1,4GlcNAc-R (α-Gal) epitope: A carbohydrate of unique evolution and clinical relevance
Bruce A. Macher,Uri Galili +1 more
TLDR
This review covers topics and new avenues of clinical importance related to this unique antigen/antibody system (α-gal epitope/anti-Gal) in improving the efficacy of viral vaccines and in immunotherapy against cancer.About:
This article is published in Biochimica et Biophysica Acta.The article was published on 2008-02-01 and is currently open access. It has received 348 citations till now. The article focuses on the topics: Epitope & Antibody.read more
Citations
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Cetuximab-Induced Anaphylaxis and IgE Specific for Galactose-α-1,3-Galactose
Christine H. Chung,Beloo Mirakhur,Emily Chan,Quynh-Thu Le,Jordan Berlin,Michael A. Morse,Barbara A. Murphy,S.M. Satinover,Jacob D. Hosen,David J. Mauro,Robbert J.C. Slebos,Qinwei Zhou,Diane R. Gold,Tina Hatley,Daniel J. Hicklin,Thomas A.E. Platts-Mills +15 more
TL;DR: In most subjects who had a hypersensitivity reaction to cetuximab, IgE antibodies against cetUXimab were present in serum before therapy, and the antibodies were specific for galactose-alpha-1,3-galactose.
Journal ArticleDOI
Glycosylation as a strategy to improve antibody-based therapeutics
TL;DR: Current knowledge of methods and avenues for their exploitation in the clinic are summarized, which allow the production of rMAbs bearing pre-selected oligosaccharides — glycoforms — to provide maximum efficacy for a given disease indication.
Journal ArticleDOI
The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line
Xun Xu,Harish Nagarajan,Nathan E. Lewis,Shengkai Pan,Zhiming Cai,Xin Liu,Wenbin Chen,Min Xie,Wenliang Wang,Stephanie Hammond,Mikael Rørdam Andersen,Norma F. Neff,Benedetto Passarelli,Winston Koh,H. Christina Fan,Jianbin Wang,Yaoting Gui,Kelvin H. Lee,Michael J. Betenbaugh,Michael J. Betenbaugh,Stephen R. Quake,Iman Famili,Bernhard O. Palsson,Jun Wang +23 more
TL;DR: A draft genomic sequence of the CHO-K1 ancestral cell line is presented and it is discussed how the availability of this genome sequence may facilitate genome-scale science for the optimization of biopharmaceutical protein production.
Journal ArticleDOI
Mammalian glycosylation in immunity
TL;DR: This Review focuses on the emerging immunological roles of the mammalian glycome, which is one of the four fundamental macromolecular components of all cells, and is highly regulated in the immune system.
Journal ArticleDOI
Delayed anaphylaxis, angioedema, or urticaria after consumption of red meat in patients with IgE antibodies specific for galactose-α-1,3-galactose.
Scott P. Commins,S.M. Satinover,Jacob D. Hosen,J. Mozena,Larry Borish,Barrett D. Lewis,Judith A. Woodfolk,Thomas A.E. Platts-Mills +7 more
TL;DR: A novel and severe food allergy related to IgE antibodies to the carbohydrate epitope alpha-gal is reported from patients who experience delayed symptoms of anaphylaxis, angioedema, or urticaria associated with eating beef, pork, or lamb.
References
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A simple method for the isolation and purification of total lipides from animal tissues.
TL;DR: In this paper, the authors described a simplified version of the method and reported the results of a study of its application to different tissues, including the efficiency of the washing procedure in terms of the removal from tissue lipides of some non-lipide substances of special biochemical interest.
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Production of α-1,3-Galactosyltransferase Knockout Pigs by Nuclear Transfer Cloning
Liangxue Lai,Donna Kolber-Simonds,Kwang-Wook Park,Hee-Tae Cheong,Julia L. Greenstein,Gi-Sun Im,Melissa Samuel,Aaron Bonk,August Rieke,Billy N. Day,Clifton N. Murphy,David B. Carter,Robert J. Hawley,Randall S. Prather +13 more
TL;DR: The production of four live pigs in which one allele of the α-1,3-galactosyltransferase locus has been knocked out is reported, paving the way for xenotransplantation of pigs from clonal fetal fibroblast cell lines.
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Assignment of intrachain disulfide bonds and characterization of potential glycosylation sites of the type 1 recombinant human immunodeficiency virus envelope glycoprotein (gp120) expressed in Chinese hamster ovary cells.
TL;DR: All 24 sites of gp120 are utilized, including 13 that contain complex- type oligosaccharides as the predominant structures, and 11 that contain primarily high mannose-type and/or hybrid-type oligosACcharide structures.
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Production of α1,3-Galactosyltransferase-Deficient Pigs
Carol Phelps,Chihiro Koike,Todd Vaught,Jeremy Boone,Kevin D. Wells,Shu-Hung Chen,Suyapa Ball,Susan Specht,Irina A. Polejaeva,Jeff A. Monahan,Pete M. Jobst,Sugandha B. Sharma,Ashley E. Lamborn,Amy S. Garst,Marilyn Moore,Anthony J. Demetris,William A. Rudert,Rita Bottino,Suzanne Bertera,Massimo Trucco,Thomas E. Starzl,Yifan Dai,David Ayares +22 more
TL;DR: The piglets carrying a point mutation in the α1,3GT gene hold significant value, as they would allow production of α1-3Gal-deficient pigs free of antibiotic-resistance genes and thus have the potential to make a safer product for human use.
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Fcγ Receptor–mediated Induction of Dendritic Cell Maturation and Major Histocompatibility Complex Class I–restricted Antigen Presentation after Immune Complex Internalization
Armelle Regnault,Danielle Lankar,Valérie Lacabanne,Ana Rodriguez,Clotilde Théry,Maria Rescigno,Takashi Saito,J. Sjef Verbeek,Christian Bonnerot,Paola Ricciardi-Castagnoli,Sebastian Amigorena +10 more
TL;DR: It is shown that FcγRs have two additional specific attributes in murine DCs: the induction of DC maturation and the promotion of efficient MHC class I–restricted presentation of peptides from exogenous, IgG-complexed antigens.