The Mutational Landscape of Prostate Cancer
Christopher E. Barbieri,Chris H. Bangma,Anders Bjartell,James W.F. Catto,Zoran Culig,Henrik Grönberg,Jun Luo,Tapio Visakorpi,Mark A. Rubin +8 more
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TLDR
The possibility that PCa could soon transition from being a poorly understood, heterogeneous disease with a variable clinical course to being a collection of homogenous subtypes identifiable by molecular criteria, associated with distinct risk profiles, and perhaps amenable to specific management strategies or targeted therapies is raised.About:
This article is published in European Urology.The article was published on 2013-10-01 and is currently open access. It has received 231 citations till now.read more
Citations
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Journal ArticleDOI
The 2016 WHO Classification of Tumours of the Urinary System and Male Genital Organs-Part B: Prostate and Bladder Tumours.
TL;DR: Modifications to the Gleason grading system are incorporated into the 2016 WHO section on grading of prostate cancer, and it is recommended that the percentage of pattern 4 should be reported for Gleason score 7.
Journal ArticleDOI
Tracking the origins and drivers of subclonal metastatic expansion in prostate cancer
Matthew K.H. Hong,Geoff Macintyre,David C. Wedge,Peter Van Loo,Keval M. Patel,Sebastian Lunke,Ludmil B. Alexandrov,Clare Sloggett,Marek Cmero,Francesco Marass,Dana W.Y. Tsui,Stefano Mangiola,Andrew Lonie,Haroon Naeem,Nikhil Sapre,Pramit M. Phal,Natalie Kurganovs,Xiaowen Chin,Michael Kerger,Anne Y. Warren,David E. Neal,Vincent Gnanapragasam,Nitzan Rosenfeld,John Pedersen,Andrew Ryan,Izhak Haviv,Anthony J. Costello,Niall M. Corcoran,Christopher M. Hovens +28 more
TL;DR: The precise direction of metastatic spread is revealed across four lethal prostate cancer patients using whole-genome and ultra-deep targeted sequencing of longitudinally collected primary and metastatic tumours and analysis of mutations associated with metastasis reveals an enrichment of TP53 mutations.
Journal ArticleDOI
Cancer genetics and genomics of human FOX family genes
TL;DR: Whole-genome sequencing data from tens of thousands of human cancers will uncover the mutational landscape of FOX family genes themselves as well as FOX-binding sites, which will be ultimately applied for cancer diagnostics, prognostics, and therapeutics.
Journal ArticleDOI
Androgen Signaling in Prostate Cancer
TL;DR: Current understanding of AR signaling as it pertains to the biology and natural history of prostate cancer is reviewed.
Journal ArticleDOI
Evolution of androgen receptor targeted therapy for advanced prostate cancer
TL;DR: This Review aims to revisit the discovery and evolution of androgen receptor targeting therapeutics for the treatment of advanced-stage prostate cancer over the years and to discuss the upcoming future and challenges in the Treatment of this common cancer.
References
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Global cancer statistics
TL;DR: A substantial proportion of the worldwide burden of cancer could be prevented through the application of existing cancer control knowledge and by implementing programs for tobacco control, vaccination, and early detection and treatment, as well as public health campaigns promoting physical activity and a healthier dietary intake.
Journal ArticleDOI
Recurrent Fusion of TMPRSS2 and ETS Transcription Factor Genes in Prostate Cancer
Scott A. Tomlins,Daniel R. Rhodes,Sven Perner,Saravana M. Dhanasekaran,Rohit Mehra,Xiao-Wei Sun,Sooryanarayana Varambally,Xuhong Cao,Joelle Tchinda,Rainer Kuefer,Charles Lee,James E. Montie,Rajal B. Shah,Kenneth J. Pienta,Mark A. Rubin,Arul M. Chinnaiyan +15 more
TL;DR: In this article, the authors used a bioinformatics approach to discover candidate oncogenic chromosomal aberrations on the basis of outlier gene expression and identified recurrent gene fusions of the 5' untranslated region of TMPRSS2 to ERG or ETV1.
Journal ArticleDOI
Integrative genomic profiling of human prostate cancer
Barry S. Taylor,Nikolaus Schultz,Haley Hieronymus,Anuradha Gopalan,Yonghong Xiao,Brett S. Carver,Vivek K. Arora,Poorvi Kaushik,Ethan Cerami,Boris Reva,Yevgeniy Antipin,Nicholas Mitsiades,Thomas Landers,Igor Dolgalev,John E. Major,Manda Wilson,Nicholas D. Socci,Alex E. Lash,Adriana Heguy,James A. Eastham,Howard I. Scher,Victor E. Reuter,Peter T. Scardino,Chris Sander,Charles L. Sawyers,Charles L. Sawyers,William L. Gerald +26 more
TL;DR: Analysis of genomic and clinical outcome data from 218 prostate cancer tumors revealed that copy-number alterations robustly define clusters of low- and high-risk disease beyond that achieved by Gleason score.
Journal ArticleDOI
The polycomb group protein EZH2 is involved in progression of prostate cancer
Sooryanarayana Varambally,Saravana M. Dhanasekaran,Ming Zhou,Terrence R. Barrette,Chandan Kumar-Sinha,Martin G. Sanda,Debashis Ghosh,Kenneth J. Pienta,Richard George Antonius Bernardus Sewalt,Arie P. Otte,Mark A. Rubin,Arul M. Chinnaiyan +11 more
TL;DR: Dysregulated expression of EZH2 may be involved in the progression of prostate cancer, as well as being a marker that distinguishes indolent prostate cancer from those at risk of lethal progression.
Journal ArticleDOI
The mutational landscape of lethal castration-resistant prostate cancer
Catherine S. Grasso,Yi-Mi Wu,Dan R. Robinson,Xuhong Cao,Saravana M. Dhanasekaran,Amjad Khan,Michael J. Quist,Xiaojun Jing,Robert J. Lonigro,J. Chad Brenner,Irfan A. Asangani,Bushra Ateeq,Sang Y. Chun,Javed Siddiqui,Lee Sam,Matt Anstett,Rohit Mehra,John R. Prensner,Nallasivam Palanisamy,Gregory A. Ryslik,Fabio Vandin,Benjamin J. Raphael,Lakshmi P. Kunju,Daniel R. Rhodes,Kenneth J. Pienta,Arul M. Chinnaiyan,Scott A. Tomlins +26 more
TL;DR: The mutational landscape of a heavily treated metastatic cancer is described, novel mechanisms of AR signalling deregulated in prostate cancer are identified, and candidates for future study are prioritize.
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