Journal ArticleDOI
The neurobiology of human aggressive behavior: Neuroimaging, genetic, and neurochemical aspects.
Francesca Anna Cupaioli,Fabio A. Zucca,Cinzia Caporale,Klaus-Peter Lesch,Luca Passamonti,Luca Passamonti,Luigi Zecca +6 more
TLDR
Considering the social burden of pathological forms of aggression, more basic and translational studies should be conducted to accelerate applications to clinical practice, justice courts, and policy making.Abstract:
In modern societies, there is a strive to improve the quality of life related to risk of crimes which inevitably requires a better understanding of brain determinants and mediators of aggression. Neurobiology provides powerful tools to achieve this end. Pre-clinical and clinical studies show that changes in regional volumes, metabolism-function and connectivity within specific neural networks are related to aggression. Subregions of prefrontal cortex, insula, amygdala, basal ganglia and hippocampus play a major role within these circuits and have been consistently implicated in biology of aggression. Genetic variations in proteins regulating the synthesis, degradation, and transport of serotonin and dopamine as well as their signal transduction have been found to mediate behavioral variability observed in aggression. Gene-gene and gene-environment interactions represent additional important risk factors for aggressiveness. Considering the social burden of pathological forms of aggression, more basic and translational studies should be conducted to accelerate applications to clinical practice, justice courts, and policy making.read more
Citations
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A population-specific HTR2B stop codon predisposes to severe impulsivity
Laura Bevilacqua,Stéphane Doly,Jaakko Kaprio,Jaakko Kaprio,Qiaoping Yuan,Roope Tikkanen,Tiina Paunio,Zhifeng Zhou,Juho Wedenoja,Juho Wedenoja,Luc Maroteaux,Silvina L. Diaz,Arnauld Belmer,Colin A. Hodgkinson,Liliana Dell'Osso,Jaana Suvisaari,Emil F. Coccaro,Richard J. Rose,Leena Peltonen,Matti Virkkunen,David Goldman +20 more
TL;DR: In this paper, a stop codon in HTR2B was identified that is common (minor allele frequency > 1%) but exclusive to Finnish people, which was associated with psychiatric diseases marked by impulsivity in both population and family-based analyses.
Genetic background of extreme violent behavior
Jari Tiihonen,M-R Rautiainen,Hanna Ollila,Eila Repo-Tiihonen,Matti Virkkunen,Aarno Palotie,Olli Pietiläinen,Kati Kristiansson,Matti Joukamaa,Hannu Lauerma,Janna Saarela,Sasu Tyni,Heikki Vartiainen,Jussi Paananen,David Goldman,Tiina Paunio +15 more
TL;DR: In this article, the authors found that both low monoamine metabolism and neuronal membrane dysfunction are plausible factors in the etiology of extreme criminal violent behavior, and imply that at least about 5-10% of all severe violent crime in Finland is attributable to the aforementioned MAOA and CDH13 genotypes.
Journal ArticleDOI
Treatment of Aggression in Adults with Autism Spectrum Disorder: A Review.
TL;DR: In this article, a review of evidence-based interventions for aggression in adults with ASD was conducted using relevant search terms, and the strongest (controlled trial) evidence suggests beneficial effects of risperidone, propranolol, fluvoxamine, vigorous aerobic exercise, and dextromethorphan/quinidine for treating aggression.
Journal Article
The impact of dopamine on aggression: An [18F]FDOPA PET study
Ingo Vernaleken,Thorben Schlüter,Kai Dautzenberg,Jörn Schmaljohann,Oliver Winz,Felix M. Mottaghy,Gerhard Gruender +6 more
TL;DR: In this article, a modified version of the Point Subtraction Aggression Paradigm (PSAP) was used to measure aggressive behavior during a monetary reward-related paradigm, where a putative adversary habitually tried to cheat.
Journal ArticleDOI
Identification of violent patients with schizophrenia using a hybrid machine learning approach at the individual level.
Ningzhi Gou,Yizhen Xiang,Jiansong Zhou,Simei Zhang,Shaoling Zhong,Juntao Lu,Xiaoxi Liang,Jin Liu,Xiaoping Wang +8 more
TL;DR: In this paper, a hybrid ML method was proposed to improve the prediction capability in 42 violent offenders with schizophrenia and 33 non-violent patients with schizophrenia, which achieved the highest prediction performance with an accuracy of 90.67%.
References
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Journal ArticleDOI
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Klaus-Peter Lesch,D. Bengel,Armin Heils,Sue Z. Sabol,Benjamin D. Greenberg,Susanne Petri,Jonathan Benjamin,Clemens R. Müller,Dean H. Hamer,Dennis L. Murphy +9 more
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Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats.
G. Di Chiara,Assunta Imperato +1 more
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Journal ArticleDOI
Role of Genotype in the Cycle of Violence in Maltreated Children
Avshalom Caspi,Avshalom Caspi,Joseph L. McClay,Terrie E. Moffitt,Terrie E. Moffitt,Jonathan Mill,Judy Martin,Ian W. Craig,Alan Taylor,Richie Poulton +9 more
TL;DR: In this paper, a large sample of male children from birth to adulthood was studied to determine why some children who are maltreated grow up to develop antisocial behavior, whereas others do not.
Journal ArticleDOI
Common SNPs explain a large proportion of the heritability for human height
Jian Yang,Beben Benyamin,Brian P. McEvoy,Scott D. Gordon,Anjali K. Henders,Dale R. Nyholt,Pamela A. F. Madden,Andrew C. Heath,Nicholas G. Martin,Grant W. Montgomery,Michael E. Goddard,Peter M. Visscher +11 more
TL;DR: Evidence is provided that the remaining heritability is due to incomplete linkage disequilibrium between causal variants and genotyped SNPs, exacerbated by causal variants having lower minor allele frequency than the SNPs explored to date.