The organization of the human cerebral cortex estimated by intrinsic functional connectivity
B.T. Thomas Yeo,Fenna M. Krienen,Jorge Sepulcre,Jorge Sepulcre,Mert R. Sabuncu,Mert R. Sabuncu,Danial Lashkari,Marisa O. Hollinshead,Marisa O. Hollinshead,Joshua L. Roffman,Jordan W. Smoller,Lilla Zöllei,Jonathan R. Polimeni,Bruce Fischl,Bruce Fischl,Hesheng Liu,Randy L. Buckner +16 more
TLDR
In this paper, the organization of networks in the human cerebrum was explored using resting-state functional connectivity MRI data from 1,000 subjects and a clustering approach was employed to identify and replicate networks of functionally coupled regions across the cerebral cortex.Abstract:
Information processing in the cerebral cortex involves interactions among distributed areas. Anatomical connectivity suggests that certain areas form local hierarchical relations such as within the visual system. Other connectivity patterns, particularly among association areas, suggest the presence of large-scale circuits without clear hierarchical relations. In this study the organization of networks in the human cerebrum was explored using resting-state functional connectivity MRI. Data from 1,000 subjects were registered using surface-based alignment. A clustering approach was employed to identify and replicate networks of functionally coupled regions across the cerebral cortex. The results revealed local networks confined to sensory and motor cortices as well as distributed networks of association regions. Within the sensory and motor cortices, functional connectivity followed topographic representations across adjacent areas. In association cortex, the connectivity patterns often showed abrupt transitions between network boundaries. Focused analyses were performed to better understand properties of network connectivity. A canonical sensory-motor pathway involving primary visual area, putative middle temporal area complex (MT+), lateral intraparietal area, and frontal eye field was analyzed to explore how interactions might arise within and between networks. Results showed that adjacent regions of the MT+ complex demonstrate differential connectivity consistent with a hierarchical pathway that spans networks. The functional connectivity of parietal and prefrontal association cortices was next explored. Distinct connectivity profiles of neighboring regions suggest they participate in distributed networks that, while showing evidence for interactions, are embedded within largely parallel, interdigitated circuits. We conclude by discussing the organization of these large-scale cerebral networks in relation to monkey anatomy and their potential evolutionary expansion in humans to support cognition.read more
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Primate Cerebellar Scaling in Connection to the Cerebrum: A 34-Species Phylogenetic Comparative Analysis
Neville Magielse,Roberto Toro,Vanessa Steigauf,Mahta Abbaspour,Simon B. Eickhoff,Katja Heuer,Sofie L. Valk +6 more
TL;DR: This article used phylogenetic generalized least squares to find that the cerebellum scales isometrically with the cerebral cortex, whereas crura I-II scales hyper-allometrinically versus both.
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Distance disintegration characterizes node-level topological dysfunctions in cocaine addiction.
Víctor Costumero,Patricia Rosell Negre,Juan Carlos Bustamante,Paola Fuentes-Claramonte,Jesús Adrián-Ventura,María-Ángeles Palomar-García,Anna Miró-Padilla,Juan José Llopis,Jorge Sepulcre,Alfonso Barrós-Loscertales +9 more
TL;DR: In this paper, the authors used resting state functional magnetic resonance imaging (fMRI) data to investigate node-level topological dysfunctions in CUD, finding that CUD individuals had higher optimal connectivity distances in ventral striatum, insula, cerebellum, temporal cortex, lateral orbitofrontal cortex, middle frontal cortex and left hippocampus.
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Memory recovery is related to default mode network impairment and neurite density during brain tumours treatment
Rafael Romero-Garcia,John Suckling,Mallory Owen,Moataz Assem,Rohitashwa Sinha,Pedro Coelho,Emma Woodberry,Stephen J. Price,Amos Burke,Thomas Santarius,Yaara Erez,Michael G Hart +11 more
TL;DR: It is suggested that brain tumours and their corresponding treatment affecting brain networks that are fundamental for memory functioning such as the DMN can have a major impact on patient’s memory recovery.
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Cortical Volume in the Right Cingulate Cortex Mediates the Increase of Self-Control From Young Adult to Middle-Aged
Lili Jiang,Chunlin Li,Yubin Li +2 more
TL;DR: In this paper , the authors explored the age dependence of cortical volume (CV) and self-control from young adult to middle-aged, as well as whether a non-linear association in the tridimensional model of age-brain-self-control was necessary to explain all the data in this study.
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Neuro-PC: Causal Functional Connectivity from Neural Dynamics
Rahul Biswas,Eli Shlizerman +1 more
TL;DR: The Neuro-PC algorithm is developed, which is a novel methodology for inferring the causal functional connectivity between neurons from multi-dimensional time series, such as neuronal recordings, and features of the mapping can be used for quantification of the similarities between neural responses subject to different stimuli.
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