The organization of the human cerebral cortex estimated by intrinsic functional connectivity
B.T. Thomas Yeo,Fenna M. Krienen,Jorge Sepulcre,Jorge Sepulcre,Mert R. Sabuncu,Mert R. Sabuncu,Danial Lashkari,Marisa O. Hollinshead,Marisa O. Hollinshead,Joshua L. Roffman,Jordan W. Smoller,Lilla Zöllei,Jonathan R. Polimeni,Bruce Fischl,Bruce Fischl,Hesheng Liu,Randy L. Buckner +16 more
TLDR
In this paper, the organization of networks in the human cerebrum was explored using resting-state functional connectivity MRI data from 1,000 subjects and a clustering approach was employed to identify and replicate networks of functionally coupled regions across the cerebral cortex.Abstract:
Information processing in the cerebral cortex involves interactions among distributed areas. Anatomical connectivity suggests that certain areas form local hierarchical relations such as within the visual system. Other connectivity patterns, particularly among association areas, suggest the presence of large-scale circuits without clear hierarchical relations. In this study the organization of networks in the human cerebrum was explored using resting-state functional connectivity MRI. Data from 1,000 subjects were registered using surface-based alignment. A clustering approach was employed to identify and replicate networks of functionally coupled regions across the cerebral cortex. The results revealed local networks confined to sensory and motor cortices as well as distributed networks of association regions. Within the sensory and motor cortices, functional connectivity followed topographic representations across adjacent areas. In association cortex, the connectivity patterns often showed abrupt transitions between network boundaries. Focused analyses were performed to better understand properties of network connectivity. A canonical sensory-motor pathway involving primary visual area, putative middle temporal area complex (MT+), lateral intraparietal area, and frontal eye field was analyzed to explore how interactions might arise within and between networks. Results showed that adjacent regions of the MT+ complex demonstrate differential connectivity consistent with a hierarchical pathway that spans networks. The functional connectivity of parietal and prefrontal association cortices was next explored. Distinct connectivity profiles of neighboring regions suggest they participate in distributed networks that, while showing evidence for interactions, are embedded within largely parallel, interdigitated circuits. We conclude by discussing the organization of these large-scale cerebral networks in relation to monkey anatomy and their potential evolutionary expansion in humans to support cognition.read more
Citations
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Prospective Validation That Subgenual Connectivity Predicts Antidepressant Efficacy of Transcranial Magnetic Stimulation Sites.
Anne Weigand,Andreas Horn,Ruth Caballero,Danielle Cooke,Adam P. Stern,Stephan F. Taylor,Daniel Z. Press,Alvaro Pascual-Leone,Michael D. Fox,Michael D. Fox +9 more
TL;DR: This study provides prospective validation that functional connectivity between an individual's rTMS cortical target and the subgenual cingulate predicts antidepressant response.
Journal ArticleDOI
Control-related systems in the human brain.
TL;DR: This article begins by introducing a psychological model of task control and several neuroimaging signals it predicts, and presents results derived from spontaneous task-free functional connectivity between control-related regions that dovetail with distinctions made by control signals present in these regions, leading to a proposal that there are at least two task control systems in the brain.
Journal ArticleDOI
Modular Segregation of Structural Brain Networks Supports the Development of Executive Function in Youth
Graham L. Baum,Rastko Ciric,David R. Roalf,Richard F. Betzel,Tyler M. Moore,Russell T. Shinohara,Ari E. Kahn,Simon N. Vandekar,Petra Rupert,Megan Quarmley,Philip A. Cook,Mark A. Elliott,Kosha Ruparel,Raquel E. Gur,Ruben C. Gur,Danielle S. Bassett,Theodore D. Satterthwaite +16 more
TL;DR: In this article, structural network modules become more segregated with age, with weaker connections between modules and stronger connections within modules, and they are associated with enhanced executive performance and mediate the improvement of executive functioning with age.
Journal ArticleDOI
Atypical functional connectome hierarchy in autism
Seok-Jun Hong,Seok-Jun Hong,Reinder Vos de Wael,Richard A. I. Bethlehem,Sara Larivière,Casey Paquola,Sofie L. Valk,Michael P. Milham,Michael P. Milham,Adriana Di Martino,Daniel S. Margulies,Jonathan Smallwood,Boris C. Bernhardt +12 more
TL;DR: Evidence of atypical connectivity transitions between sensory and higher-order cortical areas in people with ASD is provided, which could underlie the diverse symptoms.
Journal ArticleDOI
Gradients of structure-function tethering across neocortex.
Bertha Vázquez-Rodríguez,Laura E. Suárez,Ross D. Markello,Golia Shafiei,Casey Paquola,Patric Hagmann,Martijn P. van den Heuvel,Boris C. Bernhardt,R. Nathan Spreng,Bratislav Misic +9 more
TL;DR: The present results demonstrate that structural and functional networks do not align uniformly across the brain, but gradually uncouple in higher-order polysensory areas.
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