The organization of the human cerebral cortex estimated by intrinsic functional connectivity
B.T. Thomas Yeo,Fenna M. Krienen,Jorge Sepulcre,Jorge Sepulcre,Mert R. Sabuncu,Mert R. Sabuncu,Danial Lashkari,Marisa O. Hollinshead,Marisa O. Hollinshead,Joshua L. Roffman,Jordan W. Smoller,Lilla Zöllei,Jonathan R. Polimeni,Bruce Fischl,Bruce Fischl,Hesheng Liu,Randy L. Buckner +16 more
TLDR
In this paper, the organization of networks in the human cerebrum was explored using resting-state functional connectivity MRI data from 1,000 subjects and a clustering approach was employed to identify and replicate networks of functionally coupled regions across the cerebral cortex.Abstract:
Information processing in the cerebral cortex involves interactions among distributed areas. Anatomical connectivity suggests that certain areas form local hierarchical relations such as within the visual system. Other connectivity patterns, particularly among association areas, suggest the presence of large-scale circuits without clear hierarchical relations. In this study the organization of networks in the human cerebrum was explored using resting-state functional connectivity MRI. Data from 1,000 subjects were registered using surface-based alignment. A clustering approach was employed to identify and replicate networks of functionally coupled regions across the cerebral cortex. The results revealed local networks confined to sensory and motor cortices as well as distributed networks of association regions. Within the sensory and motor cortices, functional connectivity followed topographic representations across adjacent areas. In association cortex, the connectivity patterns often showed abrupt transitions between network boundaries. Focused analyses were performed to better understand properties of network connectivity. A canonical sensory-motor pathway involving primary visual area, putative middle temporal area complex (MT+), lateral intraparietal area, and frontal eye field was analyzed to explore how interactions might arise within and between networks. Results showed that adjacent regions of the MT+ complex demonstrate differential connectivity consistent with a hierarchical pathway that spans networks. The functional connectivity of parietal and prefrontal association cortices was next explored. Distinct connectivity profiles of neighboring regions suggest they participate in distributed networks that, while showing evidence for interactions, are embedded within largely parallel, interdigitated circuits. We conclude by discussing the organization of these large-scale cerebral networks in relation to monkey anatomy and their potential evolutionary expansion in humans to support cognition.read more
Citations
More filters
Journal ArticleDOI
Network measures predict neuropsychological outcome after brain injury
David E. Warren,Jonathan D. Power,Joel Bruss,Natalie L. Denburg,Eric J. Waldron,Haoxin Sun,Steven E. Petersen,Daniel Tranel +7 more
TL;DR: Study of neurological patients with focal brain lesions found that damage to hub locations produced much greater cognitive impairment than damage to other locations, and this work may improve the understanding of outcomes of brain injuries and help inform prognosis and rehabilitation efforts.
Journal ArticleDOI
Altered cerebellar connectivity in autism and cerebellar-mediated rescue of autism-related behaviors in mice
Catherine J. Stoodley,Anila M. D'Mello,Jacob Ellegood,Vikram Jakkamsetti,Pei Liu,Mary Beth Nebel,Jennifer M. Gibson,Elyza Kelly,Fan-Tao Meng,Christopher A. Cano,Juan M. Pascual,Stewart H. Mostofsky,Jason P. Lerch,Peter T. Tsai +13 more
TL;DR: This paper showed that chemogenetically mediated inhibition of RCrusI PN activity in mice was sufficient to generate ASD-related social, repetitive, and restricted behaviors, while stimulation of RcrusI PI PNs rescued social impairment in the Purkinje neuron (PN) TscI ASD mouse model.
Journal ArticleDOI
Network-Level Structure-Function Relationships in Human Neocortex
Bratislav Misic,Richard F. Betzel,Marcel A. de Reus,Martijn P. van den Heuvel,Marc G. Berman,Anthony R. McIntosh,Olaf Sporns +6 more
TL;DR: A multivariate statistical technique is deployed to investigate the association between spatially extended structural networks and functional networks and finds multiple statistically robust patterns, reflecting reliable combinations of structural and functional subnetworks that are optimally associated with one another.
Journal ArticleDOI
Classic psychedelics: An integrative review of epidemiology, therapeutics, mystical experience, and brain network function.
TL;DR: An integrative review and novel insights regarding human research with classic psychedelics (classic hallucinogens), which are serotonin 2A receptor (5‐HT2AR) agonists such as lysergic acid diethylamide (LSD), mescaline, and psilocybin, are offered.
Journal ArticleDOI
The serendipitous discovery of the brain's default network.
TL;DR: A personal perspective of the default network's serendipitous discovery is described - a set of brain regions that is spontaneously active during passive moments.
References
More filters
Journal ArticleDOI
Silhouettes: a graphical aid to the interpretation and validation of cluster analysis
TL;DR: A new graphical display is proposed for partitioning techniques, where each cluster is represented by a so-called silhouette, which is based on the comparison of its tightness and separation, and provides an evaluation of clustering validity.
Book
The Principles of Psychology
TL;DR: For instance, the authors discusses the multiplicity of the consciousness of self in the form of the stream of thought and the perception of space in the human brain, which is the basis for our work.
Journal ArticleDOI
Receptive fields, binocular interaction and functional architecture in the cat's visual cortex
David H. Hubel,Torsten N. Wiesel +1 more
TL;DR: This method is used to examine receptive fields of a more complex type and to make additional observations on binocular interaction and this approach is necessary in order to understand the behaviour of individual cells, but it fails to deal with the problem of the relationship of one cell to its neighbours.
Journal ArticleDOI
Advances in functional and structural MR image analysis and implementation as FSL.
Stephen M. Smith,Mark Jenkinson,Mark W. Woolrich,Mark W. Woolrich,Christian F. Beckmann,Behrens Tej.,Heidi Johansen-Berg,Peter R. Bannister,M De Luca,Ivana Drobnjak,D E Flitney,Rami K. Niazy,J Saunders,J Vickers,Yongyue Zhang,N. De Stefano,J M Brady,Paul M. Matthews +17 more
TL;DR: A review of the research carried out by the Analysis Group at the Oxford Centre for Functional MRI of the Brain (FMRIB) on the development of new methodologies for the analysis of both structural and functional magnetic resonance imaging data.
Journal ArticleDOI
Control of goal-directed and stimulus-driven attention in the brain
TL;DR: Evidence for partially segregated networks of brain areas that carry out different attentional functions is reviewed, finding that one system is involved in preparing and applying goal-directed selection for stimuli and responses, and the other is specialized for the detection of behaviourally relevant stimuli.