The organization of the human cerebral cortex estimated by intrinsic functional connectivity
B.T. Thomas Yeo,Fenna M. Krienen,Jorge Sepulcre,Jorge Sepulcre,Mert R. Sabuncu,Mert R. Sabuncu,Danial Lashkari,Marisa O. Hollinshead,Marisa O. Hollinshead,Joshua L. Roffman,Jordan W. Smoller,Lilla Zöllei,Jonathan R. Polimeni,Bruce Fischl,Bruce Fischl,Hesheng Liu,Randy L. Buckner +16 more
TLDR
In this paper, the organization of networks in the human cerebrum was explored using resting-state functional connectivity MRI data from 1,000 subjects and a clustering approach was employed to identify and replicate networks of functionally coupled regions across the cerebral cortex.Abstract:
Information processing in the cerebral cortex involves interactions among distributed areas. Anatomical connectivity suggests that certain areas form local hierarchical relations such as within the visual system. Other connectivity patterns, particularly among association areas, suggest the presence of large-scale circuits without clear hierarchical relations. In this study the organization of networks in the human cerebrum was explored using resting-state functional connectivity MRI. Data from 1,000 subjects were registered using surface-based alignment. A clustering approach was employed to identify and replicate networks of functionally coupled regions across the cerebral cortex. The results revealed local networks confined to sensory and motor cortices as well as distributed networks of association regions. Within the sensory and motor cortices, functional connectivity followed topographic representations across adjacent areas. In association cortex, the connectivity patterns often showed abrupt transitions between network boundaries. Focused analyses were performed to better understand properties of network connectivity. A canonical sensory-motor pathway involving primary visual area, putative middle temporal area complex (MT+), lateral intraparietal area, and frontal eye field was analyzed to explore how interactions might arise within and between networks. Results showed that adjacent regions of the MT+ complex demonstrate differential connectivity consistent with a hierarchical pathway that spans networks. The functional connectivity of parietal and prefrontal association cortices was next explored. Distinct connectivity profiles of neighboring regions suggest they participate in distributed networks that, while showing evidence for interactions, are embedded within largely parallel, interdigitated circuits. We conclude by discussing the organization of these large-scale cerebral networks in relation to monkey anatomy and their potential evolutionary expansion in humans to support cognition.read more
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Distinct functional networks within the cerebellum and their relation to cortical systems assessed with independent component analysis.
Vitaly I. Dobromyslin,David H. Salat,David H. Salat,Catherine Fortier,Catherine Fortier,Elizabeth C. Leritz,Christian F. Beckmann,William P. Milberg,William P. Milberg,Regina E. McGlinchey,Regina E. McGlinchey +10 more
TL;DR: The gain in sensitivity attained through specifying the cerebellum as a target structure with regard to the identification of robust and reliable networks is demonstrated and revealed at least one network component that was not apparent with the application of whole brain ICA.
Journal ArticleDOI
Short-term test-retest reliability of resting state fMRI metrics in children with and without attention-deficit/hyperactivity disorder.
Krishna Somandepalli,Clare Kelly,Philip T. Reiss,Philip T. Reiss,Xi-Nian Zuo,R. C. Craddock,R. C. Craddock,Chao-Gan Yan,Chao-Gan Yan,Chao-Gan Yan,Eva Petkova,Eva Petkova,Francisco X. Castellanos,Francisco X. Castellanos,Michael P. Milham,Michael P. Milham,Adriana Di Martino +16 more
TL;DR: Children with or without ADHD have moderate/high R-fMRI test–retest reliability, and regional differences in ICC related to diagnostic groups reflect underlying pathophysiology for ADHD affecting both inter and intra subject variability.
Journal ArticleDOI
Allometric Analysis Detects Brain Size-Independent Effects of Sex and Sex Chromosome Complement on Human Cerebellar Organization.
Catherine Mankiw,Min Tae M. Park,Min Tae M. Park,Paul K. Reardon,Ari M. Fish,Liv S. Clasen,Deanna Greenstein,Jay N. Giedd,Jonathan D. Blumenthal,Jason P. Lerch,Jason P. Lerch,M. Mallar Chakravarty,Armin Raznahan +12 more
TL;DR: This work uses a rare neuroimaging dataset to deconvolve the interwoven effects of sex, sex chromosome complement, and brain size on human cerebellar organization, and reveals topographically variegated scaling relationships between regional Cerebellar volume andbrain size in humans.
Journal ArticleDOI
Functional Connectivity in Multiple Cortical Networks Is Associated with Performance Across Cognitive Domains in Older Adults.
TL;DR: Examination of multiple cortical networks using Template-Based Rotation found that the FPCN mediated the relationships of the other networks with cognition, suggesting that this network may play a central role in understanding individual variation in cognition during aging
Journal ArticleDOI
Generalizability and reproducibility of functional connectivity in autism
Jace B. King,Molly B.D. Prigge,Molly B.D. Prigge,Carolyn K. King,Jubel Morgan,Jubel Morgan,Fiona L. Weathersby,J. Chancellor Fox,Douglas C. Dean,Abigail Freeman,Joaquin Alfonso M. Villaruz,Karen L. Kane,Erin D. Bigler,Andrew L. Alexander,Nicholas Lange,Brandon A. Zielinski,Janet E. Lainhart,Jeffrey S. Anderson +17 more
TL;DR: Overall, functional connectivity features predictive of autism demonstrated limited generalizability across sites, with consistent results only for large samples.
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