Journal ArticleDOI
The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation.
Peter Angel,Michael Karin +1 more
Reads0
Chats0
About:
This article is published in Biochimica et Biophysica Acta.The article was published on 1991-12-10. It has received 3397 citations till now. The article focuses on the topics: AP-1 Complex.read more
Citations
More filters
Journal ArticleDOI
c-fos proto-oncogene regulation and function
Journal ArticleDOI
MOLECULAR ASPECTS OF ALCOHOL METABOLISM: Transcription Factors Involved in Early Ethanol-Induced Liver Injury
TL;DR: Upon continued exposure to ethanol, the progression of liver injury involves ethanol metabolism via CYP2E1 and consequent oxidant stress, as well as potential direct effects of ethanol on membrane proteins that are independent of ethanol metabolism.
Journal ArticleDOI
Control of differentiation, transformation, and apoptosis in granulosa cells by oncogenes, oncoviruses, and tumor suppressor genes.
TL;DR: Involvement of the cytoskeleton in granulosa cell differentiation, transformation, and survival Genes in Granulosa Cells and Mechanism of Induction of Differentiation in Oncogene-Transformed Cells is studied.
Journal ArticleDOI
Regulation of the DNA Methyltransferase by the Ras-AP-1 Signaling Pathway
TL;DR: A potential molecular link between nodal cellular signaling pathways and the control of expression of the DNA MeTase gene is established and it is suggested that DNAMeTase is one possible downstream effector of Ras.
Journal ArticleDOI
Arsenic at very low concentrations alters glucocorticoid receptor (GR)-mediated gene activation but not GR-mediated gene repression: complex dose-response effects are closely correlated with levels of activated GR and require a functional GR DNA binding domain.
TL;DR: Mutational deletion studies indicated that the central DNA binding domain (DBD) of GR is the minimal region required for the As effect and does not require free sulfhydryls, indicating that the DBD is important for mediating these As effects.
References
More filters
Journal ArticleDOI
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
TL;DR: Using an improved method of gel electrophoresis, many hitherto unknown proteins have been found in bacteriophage T4 and some of these have been identified with specific gene products.
Journal Article
Cleavage of structural proteins during the assemble of the head of bacterio-phage T4
TL;DR: Using an improved method of gel electrophoresis, many hitherto unknown proteins have been found in bacteriophage T4 and some of these have been identified with specific gene products as mentioned in this paper.
Journal ArticleDOI
The steroid and thyroid hormone receptor superfamily
TL;DR: A superfamily of regulatory proteins that include receptors for thyroid hormone and the vertebrate morphogen retinoic acid is identified, suggesting mechanisms underlying morphogenesis and homeostasis may be more ubiquitous than previously expected.
Journal ArticleDOI
The role of protein kinase C in cell surface signal transduction and tumour promotion
TL;DR: Protein kinase C probably serves as a receptor for the tumour promoters and further exploration of the roles of this enzyme may provide clues for understanding the mechanism of cell growth and differentiation.
Journal ArticleDOI
The molecular heterogeneity of protein kinase C and its implications for cellular regulation
TL;DR: Protein kinase C is now known to be a large family of proteins, with multiple subspecies that have subtle individual enzymological characteristics, and probably have distinct functions in the processing and modulation of a variety of physiological and pathological responses to external signals.