Journal ArticleDOI
The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation.
Peter Angel,Michael Karin +1 more
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This article is published in Biochimica et Biophysica Acta.The article was published on 1991-12-10. It has received 3397 citations till now. The article focuses on the topics: AP-1 Complex.read more
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Molecular responses of human lung epithelial cells to the toxicity of copper oxide nanoparticles inferred from whole genome expression analysis.
Nobutaka Hanagata,Nobutaka Hanagata,Fei Zhuang,Fei Zhuang,Sarah Connolly,Jie Li,Nobuhiro Ogawa,Mingsheng Xu +7 more
TL;DR: Cells that survived exposure to CuO-NPs arrested the cell cycle as a result of the downregulation of proliferating cell nuclear antigen, cell division control 2, cyclin B1, CCNB1, TPX2, AURKA, and AURKB.
Journal ArticleDOI
Metallothionein in physiological and physiopathological processes
Pierre Moffatt,Francine Denizeau +1 more
TL;DR: The metal composition of MT appears to be an important factor to consider in determining the overall effect of MT in the resistance process.
Journal ArticleDOI
Modulation of redox-sensitive transcription factors by calorie restriction during aging.
TL;DR: Age-related increases in redox-sensitive NF-kappaB, AP-1, and HIF-1 binding activities are concluded to be associated with increased ROS and CR to modulate their activations by suppressing oxidative stress.
Journal ArticleDOI
Regulation of human involucrin promoter activity by a protein kinase C, Ras, MEKK1, MEK3, p38/RK, AP1 signal transduction pathway
TL;DR: Results suggest that activation of involucrin transcription involves a pathway that includes protein kinase C, Ras, MEKK1, MEK3, and p38/RK, and AP1 transcription factors appear to be the ultimate target of this regulation.
Journal ArticleDOI
p38 isoforms have opposite effects on AP-1-dependent transcription through regulation of c-Jun: The determinant role of the isoforms in the p38 MAPK signal specificity
Rocky Pramanik,Xiaomei Qi,Stanley Borowicz,Divaker Choubey,Richard M. Schultz,Jiahuai Han,Guan Chen +6 more
TL;DR: It is shown that the expression profile of p38 isoforms determines whether the p38 signal pathway activates or inhibits AP-1-dependent processes and the levels of endogenous c-Jun and its phosphorylated form on p38 activation are higher in NIH 3T3 cells.
References
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Journal ArticleDOI
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
TL;DR: Using an improved method of gel electrophoresis, many hitherto unknown proteins have been found in bacteriophage T4 and some of these have been identified with specific gene products.
Journal Article
Cleavage of structural proteins during the assemble of the head of bacterio-phage T4
TL;DR: Using an improved method of gel electrophoresis, many hitherto unknown proteins have been found in bacteriophage T4 and some of these have been identified with specific gene products as mentioned in this paper.
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The steroid and thyroid hormone receptor superfamily
TL;DR: A superfamily of regulatory proteins that include receptors for thyroid hormone and the vertebrate morphogen retinoic acid is identified, suggesting mechanisms underlying morphogenesis and homeostasis may be more ubiquitous than previously expected.
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The role of protein kinase C in cell surface signal transduction and tumour promotion
TL;DR: Protein kinase C probably serves as a receptor for the tumour promoters and further exploration of the roles of this enzyme may provide clues for understanding the mechanism of cell growth and differentiation.
Journal ArticleDOI
The molecular heterogeneity of protein kinase C and its implications for cellular regulation
TL;DR: Protein kinase C is now known to be a large family of proteins, with multiple subspecies that have subtle individual enzymological characteristics, and probably have distinct functions in the processing and modulation of a variety of physiological and pathological responses to external signals.