Journal ArticleDOI
The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation.
Peter Angel,Michael Karin +1 more
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This article is published in Biochimica et Biophysica Acta.The article was published on 1991-12-10. It has received 3397 citations till now. The article focuses on the topics: AP-1 Complex.read more
Citations
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Free Radicals in the Physiological Control of Cell Function
TL;DR: There is growing evidence that aging involves, in addition, progressive changes in free radical-mediated regulatory processes that result in altered gene expression.
Journal ArticleDOI
Allergic Rhinitis and Its Impact on Asthma
TL;DR: This systematic review and meta-analyses confirmed the findings of a previous study published in “Rhinitis and Asthma: Causes and Prevention, 2nd Ed.” (2015) as well as new findings of “Mechanisms of Respiratory Disease and Allergology,” which confirmed the role of EMTs in the development of these diseases.
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JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain
Benoit Dérijard,Benoit Dérijard,Masahiko Hibi,I-Huan Wu,I-Huan Wu,Tamera Barrett,Bing Su,Tiliang Deng,Michael Karin,Roger J. Davis,Roger J. Davis +10 more
TL;DR: JNK1 is a component of a novel signal transduction pathway that is activated by oncoproteins and UV irradiation and its properties indicate that JNK1 activation may play an important role in tumor promotion.
Journal ArticleDOI
AP-1 function and regulation.
TL;DR: This work has shown that regulation by heterodimerization between Jun, Fos and ATF proteins, AP-1 activity is regulated through interactions with specific protein kinases and a variety of transcriptional coactivators, and there has been considerable progress in understanding some of the mechanisms and signaling pathways involved in the regulation of AP.
Journal ArticleDOI
AP-1 as a regulator of cell life and death
Eitan Shaulian,Michael Karin +1 more
TL;DR: Interestingly, the growth-promoting activity of c-Jun is mediated by repression of tumour suppressors, as well as upregulation of positive cell cycle regulators, whereas JunB has the converse effect.
References
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Activation of transcription by two factors that bind promoter and enhancer sequences of the human metallothionein gene and SV40
TL;DR: The identification of two cellular DNA-binding proteins that interact selectively with sequences governing the basal level expression of hMTIIA, a novel activator protein (API) that interacts with sequences in the BLE of h MTIIA and also binds to a site within the 72-base pair repeats of the simian virus 40 (SV40) enhancer region.
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Autoinduction of transforming growth factor beta 1 is mediated by the AP-1 complex.
Seong-Jin Kim,Peter Angel,Robert Lafyatis,Kazue Hattori,Kyung Young Kim,Michael B. Sporn,Michael Karin,Anita B. Roberts +7 more
TL;DR: These results demonstrate that both components of the AP-1 complex are required for TGF-beta 1 autoinduction, and may amplify the action of TGF -beta 1 during normal development and oncogenesis.
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Jun-B differs in its biological properties from, and is a negative regulator of, c-Jun.
TL;DR: Using chimeric proteins, it is shown that the distinct behavior of c-Jun and Jun-B is due to differences in their activation domains, which greatly expands the regulatory potential of the Jun family.
Journal ArticleDOI
Negative effect of the transcriptional activator GAL4
Grace Gill,Mark Ptashne +1 more
TL;DR: It is suggested that this inhibition, which the authors call squelching, reflects titration of a transcription factor by the activating region of GAL4, and that more efficient activators inhibit more strongly and that inhibition does not depend on the DNA-binding domain.
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Trans-acting protein factors and the regulation of eukaryotic transcription: lessons from studies on DNA tumor viruses.
TL;DR: It is now clear that many promoters, particularly those of 'housekeeping' genes, lack TATA boxes and are instead composed of GC-rich elements that are often located within methylation-free islands (Bird 1986).