Journal ArticleDOI
The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation.
Peter Angel,Michael Karin +1 more
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This article is published in Biochimica et Biophysica Acta.The article was published on 1991-12-10. It has received 3397 citations till now. The article focuses on the topics: AP-1 Complex.read more
Citations
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Free Radicals in the Physiological Control of Cell Function
TL;DR: There is growing evidence that aging involves, in addition, progressive changes in free radical-mediated regulatory processes that result in altered gene expression.
Journal ArticleDOI
Allergic Rhinitis and Its Impact on Asthma
TL;DR: This systematic review and meta-analyses confirmed the findings of a previous study published in “Rhinitis and Asthma: Causes and Prevention, 2nd Ed.” (2015) as well as new findings of “Mechanisms of Respiratory Disease and Allergology,” which confirmed the role of EMTs in the development of these diseases.
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JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain
Benoit Dérijard,Benoit Dérijard,Masahiko Hibi,I-Huan Wu,I-Huan Wu,Tamera Barrett,Bing Su,Tiliang Deng,Michael Karin,Roger J. Davis,Roger J. Davis +10 more
TL;DR: JNK1 is a component of a novel signal transduction pathway that is activated by oncoproteins and UV irradiation and its properties indicate that JNK1 activation may play an important role in tumor promotion.
Journal ArticleDOI
AP-1 function and regulation.
TL;DR: This work has shown that regulation by heterodimerization between Jun, Fos and ATF proteins, AP-1 activity is regulated through interactions with specific protein kinases and a variety of transcriptional coactivators, and there has been considerable progress in understanding some of the mechanisms and signaling pathways involved in the regulation of AP.
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AP-1 as a regulator of cell life and death
Eitan Shaulian,Michael Karin +1 more
TL;DR: Interestingly, the growth-promoting activity of c-Jun is mediated by repression of tumour suppressors, as well as upregulation of positive cell cycle regulators, whereas JunB has the converse effect.
References
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DNA binding activities of three murine Jun proteins: stimulation by Fos.
TL;DR: The general conclusion is that c-Jun, Jun-B, and Jun-D are similar in their DNA binding properties and in their interaction with Fos, and if there are functional differences between them, they are likely to involve other activities of the Jun proteins.
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Stimulation of neuronal acetylcholine receptors induces rapid gene transcription
TL;DR: It is suggested that neurotransmitters may rapidly activate specific gene transcription in nondividing neuronally differentiated cells and a functional role for neurotransmitter induction of c-fos and actin expression in the nervous system is suggested.
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Transient accumulation of c-fos RNA following serum stimulation requires a conserved 5' element and c-fos 3' sequences.
TL;DR: The study of fusion genes showed that in addition to the 5' activating element, transient accumulation of c-fosH RNA following serum stimulation requires sequences at the 3' end of the c- fosH gene.
Journal ArticleDOI
The role of the leucine zipper in the fos–jun interaction
Tony Kouzarides,Edward B. Ziff +1 more
TL;DR: It is shown that the complex between fos and jun can bind to DNA more tightly than either protein alone and that basic residues adjacent to the leucine repeat offos contribute to the DNA-binding potential of the complex.
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The pituitary-specific transcription factor GHF-1 is a homeobox-containing protein
Mordechai Bodner,José-Luis Castriilo,Lars E. Theill,Thomas J. Deerinck,Mark H. Ellisman,Michael Karin +5 more
TL;DR: The isolation of bovine and rat GHF-1 cDNA clones is described and it is indicated that this region of the protein functions as its DNA binding domain, which correlates with the selective transcription of its target, the GH gene.