Journal ArticleDOI
The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation.
Peter Angel,Michael Karin +1 more
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This article is published in Biochimica et Biophysica Acta.The article was published on 1991-12-10. It has received 3397 citations till now. The article focuses on the topics: AP-1 Complex.read more
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Structural and Functional Analysis of the Rainbow Trout (Oncorhyncus mykiss) Metallothionein‐A Gene
TL;DR: The distal part of the 5'-flanking region of the rainbow trout metallothionein-A promoter was sequenced in order to identify cis-acting regulatory elements and was found to be functional in promoting gene transcription following exposure of RTH-149 cells to hydrogen peroxide.
Journal ArticleDOI
NF-IL6 and AP-1 cooperatively modulate the activation of the TSG-6 gene by tumor necrosis factor alpha and interleukin-1.
TL;DR: The finding that the inhibitor isoform antagonizes activation of the native TSG-6 promoter by IL-1 and TNF-alpha suggests that NF-IL6 has a physiologic role in these cytokine responses.
Journal ArticleDOI
An ATF/CRE Element Mediates both EBNA2-Dependent and EBNA2-Independent Activation of the Epstein-Barr Virus LMP1 Gene Promoter
TL;DR: The results suggest that EBNA2-induced transactivation via the ATF/CRE site occurs through a direct contact between EB NA2 and an ATF-2/c-Jun heterodimeric complex.
Journal ArticleDOI
Cyclosporin A elicits dose-dependent biphasic effects on osteoblast differentiation and bone formation.
TL;DR: It is shown that low concentrations of CsA are anabolic as they increase bone formation, osteoblast differentiation, and bone mass, while high concentrations elicit an opposite and catabolic response.
Journal ArticleDOI
Function of AP-1 target genes in mesenchymal-epithelial cross-talk in skin.
Peter Angel,Axel Szabowski +1 more
TL;DR: Current knowledge on the molecular mechanisms underlying AP-1-dependent mesenchymal-epithelial interactions are summarized and the physiological relevance of these in vitro findings in skin physiology and pathology is discussed.
References
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Journal ArticleDOI
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
TL;DR: Using an improved method of gel electrophoresis, many hitherto unknown proteins have been found in bacteriophage T4 and some of these have been identified with specific gene products.
Journal Article
Cleavage of structural proteins during the assemble of the head of bacterio-phage T4
TL;DR: Using an improved method of gel electrophoresis, many hitherto unknown proteins have been found in bacteriophage T4 and some of these have been identified with specific gene products as mentioned in this paper.
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The steroid and thyroid hormone receptor superfamily
TL;DR: A superfamily of regulatory proteins that include receptors for thyroid hormone and the vertebrate morphogen retinoic acid is identified, suggesting mechanisms underlying morphogenesis and homeostasis may be more ubiquitous than previously expected.
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The role of protein kinase C in cell surface signal transduction and tumour promotion
TL;DR: Protein kinase C probably serves as a receptor for the tumour promoters and further exploration of the roles of this enzyme may provide clues for understanding the mechanism of cell growth and differentiation.
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The molecular heterogeneity of protein kinase C and its implications for cellular regulation
TL;DR: Protein kinase C is now known to be a large family of proteins, with multiple subspecies that have subtle individual enzymological characteristics, and probably have distinct functions in the processing and modulation of a variety of physiological and pathological responses to external signals.