Journal ArticleDOI
The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation.
Peter Angel,Michael Karin +1 more
Reads0
Chats0
About:
This article is published in Biochimica et Biophysica Acta.The article was published on 1991-12-10. It has received 3397 citations till now. The article focuses on the topics: AP-1 Complex.read more
Citations
More filters
Journal ArticleDOI
c-fos Controls the “Private Pathway” of Light-Induced Apoptosis of Retinal Photoreceptors
Andreas Wenzel,Christian Grimm,Andreas Marti,Nicole Kueng-Hitz,Farhad Hafezi,Günter Niemeyer,Charlotte E. Remé +6 more
TL;DR: Hafezi et al. as discussed by the authors showed that light-exposed c-fos+/- mice showed increased activity of the transcription factor activator protein-1 (AP-1) in retinas, indicating an acute contribution of AP-1 to apoptosis induction.
Journal ArticleDOI
Nicotinic regulation of c-fos and osteopontin expression in human-derived osteoblast-like cells and human trabecular bone organ culture.
TL;DR: It is suggested that nicotine has a direct effect on human bone cells in modulating proliferation, upregulation of the c-fos transcription factor, and the synthesis of the bone matrix protein, osteopontin.
Journal ArticleDOI
Impaired CD28-mediated Interleukin 2 Production and Proliferation in Stress Kinase SAPK/ERK1 Kinase (SEK1)/Mitogen-activated Protein Kinase Kinase 4 (MKK4)-deficient T Lymphocytes
Hiroshi Nishina,Martin F. Bachmann,Antonio J. Oliveira-dos-Santos,Ivona Kozieradzki,Klaus D. Fischer,Bernhard Odermatt,Andrew Wakeham,Arda Shahinian,Hiroaki Takimoto,Alan Bernstein,Tak W. Mak,James R. Woodgett,Pamela S. Ohashi,Josef M. Penninger +13 more
TL;DR: The results show that signaling pathways for SAPK activation are developmentally regulated in T cells, and provide the first genetic evidence that SEK1 is an important effector molecule that relays CD28 signaling to IL-2 production and T cell proliferation.
Journal Article
Inhibition of xanthine oxidase by catechins from tea (Camellia sinensis)
TL;DR: Tea catechins may act at an earlier stage than has previously been suspected, by inhibiting ROS production, rather than only neutralizing the already formed ROS, which suggests a new mechanism whereby tea drinking may prevent oxidative stress related diseases, e.g. atherosclerosis and cancer.
Journal ArticleDOI
Role of oxidative stress in intermittent hypoxia‐induced immediate early gene activation in rat PC12 cells
Guoxiang Yuan,Gautam Adhikary,Andrew A. McCormick,John. J. Holcroft,Ganesh K. Kumar,Nanduri R. Prabhakar +5 more
TL;DR: IH‐induced c‐fos‐mediated transcriptional activation involves oxidative stress, and the involvement of the mitochondrial electron transport chain in the generation of superoxide anions during IH is suggested.
References
More filters
Journal ArticleDOI
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
TL;DR: Using an improved method of gel electrophoresis, many hitherto unknown proteins have been found in bacteriophage T4 and some of these have been identified with specific gene products.
Journal Article
Cleavage of structural proteins during the assemble of the head of bacterio-phage T4
TL;DR: Using an improved method of gel electrophoresis, many hitherto unknown proteins have been found in bacteriophage T4 and some of these have been identified with specific gene products as mentioned in this paper.
Journal ArticleDOI
The steroid and thyroid hormone receptor superfamily
TL;DR: A superfamily of regulatory proteins that include receptors for thyroid hormone and the vertebrate morphogen retinoic acid is identified, suggesting mechanisms underlying morphogenesis and homeostasis may be more ubiquitous than previously expected.
Journal ArticleDOI
The role of protein kinase C in cell surface signal transduction and tumour promotion
TL;DR: Protein kinase C probably serves as a receptor for the tumour promoters and further exploration of the roles of this enzyme may provide clues for understanding the mechanism of cell growth and differentiation.
Journal ArticleDOI
The molecular heterogeneity of protein kinase C and its implications for cellular regulation
TL;DR: Protein kinase C is now known to be a large family of proteins, with multiple subspecies that have subtle individual enzymological characteristics, and probably have distinct functions in the processing and modulation of a variety of physiological and pathological responses to external signals.