Journal ArticleDOI
The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation.
Peter Angel,Michael Karin +1 more
Reads0
Chats0
About:
This article is published in Biochimica et Biophysica Acta.The article was published on 1991-12-10. It has received 3397 citations till now. The article focuses on the topics: AP-1 Complex.read more
Citations
More filters
Journal ArticleDOI
JunB Forms the Majority of the AP-1 Complex and Is a Target for Redox Regulation by Receptor Tyrosine Kinase and G Protein-coupled Receptor Agonists in Smooth Muscle Cells
TL;DR: A role for NADH/NADPH oxidase activity in some subset of early signaling events such as p38 MAP kinase activation and c-Fos and JunB induction, which appear to be important in agonist-induced AP-1 activity and DNA synthesis in VSMC are suggested.
Journal ArticleDOI
Cartilage breakdown in rheumatoid arthritis.
TL;DR: Results suggest that the mediators function as a network and that inhibition of a single mediator can affect the entire web, and that TNF antagonists are potent inhibitors of joint destruction in clinical practice.
Journal ArticleDOI
Direct evidence of high DNA binding activity of transcription factor AP-1 in rheumatoid arthritis synovium
Hiroshi Asahara,Koushi Fujisawa,Tetsuji Kobata,Tomoko Hasunuma,Toshiro Maeda,Masato Asanuma,Norio Ogawa,Hajime Inoue,Takayuki Sumida,Kusuki Nishioka +9 more
TL;DR: Findings suggest that AP-1 may play an important role in the pathogenesis of RA, including synovial hyperplasia and abnormal immune responses.
Journal ArticleDOI
Studies on the contribution of c-fos/AP-1 to arthritic joint destruction.
TL;DR: In this paper, a short double-stranded AP-1 DNA oligonucleotides were administered to mice with collagen-induced arthritis to compete for the binding of the AP binding site at the promoter binding site.
Journal ArticleDOI
Contrasting effects of alendronate and clodronate on RAW 264 macrophages: the role of a bisphosphonate metabolite.
Niina Makkonen,Antero Salminen,Michael J. Rogers,Julie C. Frith,Arto Urtti,Elena Azhayeva,Jukka Mönkkönen +6 more
TL;DR: It is suggested that the metabolite of clodronate may be responsible for the anti-inflammatory properties of cladronate, and that the contrasting effects of different bisphosphonates on the release of cytokines could be mediated partly through changes in the DNA binding activity of NF-kappaB.
References
More filters
Journal ArticleDOI
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
TL;DR: Using an improved method of gel electrophoresis, many hitherto unknown proteins have been found in bacteriophage T4 and some of these have been identified with specific gene products.
Journal Article
Cleavage of structural proteins during the assemble of the head of bacterio-phage T4
TL;DR: Using an improved method of gel electrophoresis, many hitherto unknown proteins have been found in bacteriophage T4 and some of these have been identified with specific gene products as mentioned in this paper.
Journal ArticleDOI
The steroid and thyroid hormone receptor superfamily
TL;DR: A superfamily of regulatory proteins that include receptors for thyroid hormone and the vertebrate morphogen retinoic acid is identified, suggesting mechanisms underlying morphogenesis and homeostasis may be more ubiquitous than previously expected.
Journal ArticleDOI
The role of protein kinase C in cell surface signal transduction and tumour promotion
TL;DR: Protein kinase C probably serves as a receptor for the tumour promoters and further exploration of the roles of this enzyme may provide clues for understanding the mechanism of cell growth and differentiation.
Journal ArticleDOI
The molecular heterogeneity of protein kinase C and its implications for cellular regulation
TL;DR: Protein kinase C is now known to be a large family of proteins, with multiple subspecies that have subtle individual enzymological characteristics, and probably have distinct functions in the processing and modulation of a variety of physiological and pathological responses to external signals.