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The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation.
Peter Angel,Michael Karin +1 more
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This article is published in Biochimica et Biophysica Acta.The article was published on 1991-12-10. It has received 3397 citations till now. The article focuses on the topics: AP-1 Complex.read more
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Chrysin inhibits tumor promoter-induced MMP-9 expression by blocking AP-1 via suppression of ERK and JNK pathways in gastric cancer cells.
Yong Xia,Sen Lian,Pham Ngoc Khoi,Hyun Joong Yoon,Young Eun Joo,Kee Oh Chay,Kyung Keun Kim,Young Do Jung +7 more
TL;DR: The results suggest that chrysin may exert at least part of its anticancer effect by controlling MMP-9 expression through suppression of AP-1 activity via a block of the JNK1-2 and ERK1/2 signaling pathways in gastric cancer AGS cells.
Journal ArticleDOI
The C-terminal domain of c-fos is required for activation of an AP-1 site specific for jun-fos heterodimers.
Kevin M. McBride,Mona Nemer +1 more
TL;DR: It is suggested that phosphorylation of the C terminus of c-fos affects its transactivation properties and provides evidence for novel regulatory mechanisms that may contribute to biologic specificities of the AP-1 transcription complex.
Journal ArticleDOI
Characterization of promoter elements required for cell-specific expression of the neurotensin/neuromedin N gene in a human endocrine cell line.
TL;DR: It is speculated that a complex pattern of regulation requiring interaction between a proximal CRE/AP-1-like motif and other upstream control elements play an important role in the high-level constitutive expression of NT/N in the human endocrine cell line BON.
inflammation and tumor promotion in a strain-dependent manner
TL;DR: It is demonstrated that V2O5, an occupational and environmentally relevant metal oxide, functions as an in vivo lung tumor promoter among different inbred strains of mice and a positive relationship between tumor promotion and susceptibility to V2 O5-induced pulmonary inflammation is identified.
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Growth factor signaling pathways as targets for prevention of epithelial carcinogenesis.
TL;DR: It is suggested that GFR signaling and subsequent downstream signaling pathways are potential targets for the prevention of epithelial cancers including skin cancer.
References
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Journal ArticleDOI
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
TL;DR: Using an improved method of gel electrophoresis, many hitherto unknown proteins have been found in bacteriophage T4 and some of these have been identified with specific gene products.
Journal Article
Cleavage of structural proteins during the assemble of the head of bacterio-phage T4
TL;DR: Using an improved method of gel electrophoresis, many hitherto unknown proteins have been found in bacteriophage T4 and some of these have been identified with specific gene products as mentioned in this paper.
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The steroid and thyroid hormone receptor superfamily
TL;DR: A superfamily of regulatory proteins that include receptors for thyroid hormone and the vertebrate morphogen retinoic acid is identified, suggesting mechanisms underlying morphogenesis and homeostasis may be more ubiquitous than previously expected.
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The role of protein kinase C in cell surface signal transduction and tumour promotion
TL;DR: Protein kinase C probably serves as a receptor for the tumour promoters and further exploration of the roles of this enzyme may provide clues for understanding the mechanism of cell growth and differentiation.
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The molecular heterogeneity of protein kinase C and its implications for cellular regulation
TL;DR: Protein kinase C is now known to be a large family of proteins, with multiple subspecies that have subtle individual enzymological characteristics, and probably have distinct functions in the processing and modulation of a variety of physiological and pathological responses to external signals.