Journal ArticleDOI
The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation.
Peter Angel,Michael Karin +1 more
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This article is published in Biochimica et Biophysica Acta.The article was published on 1991-12-10. It has received 3397 citations till now. The article focuses on the topics: AP-1 Complex.read more
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Suppression of Skin Tumorigenesis in c-Jun NH2-Terminal Kinase-2-Deficient Mice
Nanyue Chen,Masaaki Nomura,Qing-Bai She,Wei-Ya Ma,Ann M. Bode,Linan Wang,Richard A. Flavell,Zigang Dong +7 more
TL;DR: It is shown that in JNK2-deficient (Jnk2(-/-)) mice, the multiplicity of papillomas induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) was lower than that in wild-type mice, and data suggest that J NK2 is critical in the tumor promotion process.
Journal ArticleDOI
Patterns of regulatory activity across diverse human cell types predict tissue identity, transcription factor binding, and long-range interactions
Nathan C. Sheffield,Robert E. Thurman,Lingyun Song,Alexias Safi,John A. Stamatoyannopoulos,Boris Lenhard,Gregory E. Crawford,Terrence S. Furey +7 more
TL;DR: A classifier that accurately predicts cell-type lineage based on only 43 DHSs is developed and a similar classifier identified three sex-specific loci on the X chromosome, including the XIST lincRNA locus.
BookDOI
Ubiquitin and the biology of the cell
TL;DR: The Ubiquitin System: Past, Present and Future Perspectives A.D. Wilkinson, M. Hochstrasser, D. Kornitzer and the Molecular Pathology of Human Disease R.J. Mayer.
Journal ArticleDOI
The paradox of arsenic: molecular mechanisms of cell transformation and chemotherapeutic effects
Ann M. Bode,Zigang Dong +1 more
TL;DR: The primary purpose of this review is to examine recent findings, from this laboratory and others, that focus on the molecular mechanisms of arsenic's actions in cell transformation and as a therapeutic agent.
Journal ArticleDOI
CREB binding protein is a coactivator for the androgen receptor and mediates cross-talk with AP-1.
TL;DR: CBP significantly increased the ability of endogenous AR in LNCaP cells to activate transcription from an AR-dependent reporter construct and that the transcriptional interference between AR and AP-1 is the result of competition for limiting amounts of CBP in the cell.
References
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Journal ArticleDOI
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
TL;DR: Using an improved method of gel electrophoresis, many hitherto unknown proteins have been found in bacteriophage T4 and some of these have been identified with specific gene products.
Journal Article
Cleavage of structural proteins during the assemble of the head of bacterio-phage T4
TL;DR: Using an improved method of gel electrophoresis, many hitherto unknown proteins have been found in bacteriophage T4 and some of these have been identified with specific gene products as mentioned in this paper.
Journal ArticleDOI
The steroid and thyroid hormone receptor superfamily
TL;DR: A superfamily of regulatory proteins that include receptors for thyroid hormone and the vertebrate morphogen retinoic acid is identified, suggesting mechanisms underlying morphogenesis and homeostasis may be more ubiquitous than previously expected.
Journal ArticleDOI
The role of protein kinase C in cell surface signal transduction and tumour promotion
TL;DR: Protein kinase C probably serves as a receptor for the tumour promoters and further exploration of the roles of this enzyme may provide clues for understanding the mechanism of cell growth and differentiation.
Journal ArticleDOI
The molecular heterogeneity of protein kinase C and its implications for cellular regulation
TL;DR: Protein kinase C is now known to be a large family of proteins, with multiple subspecies that have subtle individual enzymological characteristics, and probably have distinct functions in the processing and modulation of a variety of physiological and pathological responses to external signals.