The Role of Lung and Gut Microbiota in the Pathology of Asthma
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TLDR
This review focuses on recently discovered connections between lung and gut microbiota, including bacteria, fungi, viruses, and archaea, and their influence on asthma.About:
This article is published in Immunity.The article was published on 2020-02-18 and is currently open access. It has received 271 citations till now. The article focuses on the topics: Dysbiosis & Microbiome.read more
Citations
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Journal ArticleDOI
Microbiota in health and diseases
Kaijian Hou,Zhuo-Xun Wu,Xuan-Yu Chen,Jing-Quan Wang,Dongya Zhang,Chuan Xiao,Dan Zhu,Jagadish B. Koya,Liuya Wei,Jilin Li,Zhe S Chen +10 more
TL;DR: The role of microbiota in health and diseases is highlighted by numerous studies since its discovery as mentioned in this paper , which can lead to dysregulation of bodily functions and diseases including cardiovascular diseases (CVDs), cancers, respiratory diseases, etc.
Journal ArticleDOI
Elevated Faecal 12,13-diHome Concentration in Neonates at High Risk for Asthma Is Produced by Gut Bacteria and Impedes Immune Tolerance
Sophia R. Levan,Kelsey A. Stamnes,Din L. Lin,Ariane R. Panzer,Elle Fukui,Katherine McCauley,Kei E. Fujimura,Michelle McKean,Dennis R. Ownby,Edward M. Zoratti,Homer A. Boushey,Michael D. Cabana,Christine Cole Johnson,Susan V. Lynch +13 more
TL;DR: The data indicate that elevated 12,13-diHOME concentrations impede immune tolerance and may be produced by bacterial EHs in the neonatal gut, offering a mechanistic link between perturbation of the gut microbiome during early life and atopy and asthma during childhood.
Journal ArticleDOI
Immunology of COVID-19: Mechanisms, clinical outcome, diagnostics, and perspectives-A report of the European Academy of Allergy and Clinical Immunology (EAACI).
Milena Sokolowska,Zuzanna Lukasik,Zuzanna Lukasik,Ioana Agache,Cezmi A. Akdis,Deniz Akdis,Mübeccel Akdis,Weronika Barcik,Helen A. Brough,Thomas Eiwegger,Andrzej Eljaszewicz,Stefanie Eyerich,Wojciech Feleszko,Cristina Gomez-Casado,Karin Hoffmann-Sommergruber,Jozef Janda,Rodrigo Jiménez-Saiz,Rodrigo Jiménez-Saiz,Marek Jutel,Edward F. Knol,Inge Kortekaas Krohn,Akash Kothari,Joanna Makowska,Marcin Moniuszko,Hideaki Morita,Liam O'Mahony,Kari C. Nadeau,Cevdet Ozdemir,Isabella Pali-Schöll,Isabella Pali-Schöll,Oscar Palomares,Francesco Papaleo,Mary Prunicki,Carsten B. Schmidt-Weber,Anna Sediva,Jürgen Schwarze,Mohamed H. Shamji,Gerdien A. Tramper-Stranders,Willem van de Veen,Eva Untersmayr +39 more
TL;DR: The differences between adequate innate and adaptive immune response in mild disease and the deep immune dysfunction in the severe multiorgan disease are characterized and the knowledge gaps and urgent research requirements are highlighted to provide a quick roadmap for ongoing and needed COVID‐19 studies.
Journal ArticleDOI
The potential application of probiotics and prebiotics for the prevention and treatment of COVID-19.
Amin N. Olaimat,Iman Aolymat,Murad A. Al-Holy,Mutamed M. Ayyash,Mahmoud Abu Ghoush,Anas A. Al-Nabulsi,Tareq M. Osaili,Tareq M. Osaili,Vasso Apostolopoulos,Shao-Quan Liu,Nagendra P. Shah +10 more
TL;DR: Clinical studies of the use of probiotic supplementation to prevent or treat respiratory tract infections lead to promising benefits of probiotics in reducing the risk of COVID-19.
References
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Peter J. Turnbaugh,Ruth E. Ley,Micah Hamady,Claire M. Fraser-Liggett,Rob Knight,Jeffrey I. Gordon +5 more
TL;DR: A strategy to understand the microbial components of the human genetic and metabolic landscape and how they contribute to normal physiology and predisposition to disease.
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Catherine A. Lozupone,Jesse Stombaugh,Jeffrey I. Gordon,Janet K. Jansson,Rob Knight,Rob Knight +5 more
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Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation
Nicholas Arpaia,Clarissa Campbell,Xiying Fan,Stanislav Dikiy,Joris van der Veeken,Paul deRoos,Hui Liu,Justin R. Cross,Klaus Pfeffer,Paul J. Coffer,Alexander Y. Rudensky +10 more
TL;DR: The results suggest that bacterial metabolites mediate communication between the commensal microbiota and the immune system, affecting the balance between pro- and anti-inflammatory mechanisms.
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International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma
Kian Fan Chung,Sally E. Wenzel,Jan Brozek,Andrew Bush,Mario Castro,Peter J. Sterk,Ian M. Adcock,Eric D. Bateman,Elisabeth H. Bel,Eugene R. Bleecker,Louis-Philippe Boulet,Christopher E. Brightling,Pascal Chanez,Sven-Erik Dahlén,Ratko Djukanovic,Urs Frey,Mina Gaga,Peter G. Gibson,Qutayba Hamid,Nizar N. Jajour,Thais Mauad,Ronald L. Sorkness,W. Gerald Teague +22 more
TL;DR: Recommendations and guidelines on the evaluation and treatment of severe asthma in children and adults and coordinated research efforts for improved phenotyping will provide safe and effective biomarker-driven approaches to severe asthma therapy are provided.
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Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis
Aurélien Trompette,Eva S. Gollwitzer,Koshika Yadava,Anke Sichelstiel,Norbert Sprenger,Catherine Ngom-Bru,Carine Blanchard,Tobias Junt,Laurent P. Nicod,Nicola L. Harris,Benjamin J. Marsland +10 more
TL;DR: The results show that dietary fermentable fiber and SCFAs can shape the immunological environment in the lung and influence the severity of allergic inflammation.
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