Journal ArticleDOI
Therapeutic modulation of the phosphatidylinositol 3-kinases (PI3K) pathway in cerebral ischemic injury.
TLDR
In this article, a review elaborates the mechanistic interventions of the PI3K pathway in cerebral ischemic injury in context to nuclear factor erythroid 2-related factor 2 (Nrf2) regulation, Hypoxia-inducible factor 1 signaling (HIF-1), growth factors, Endothelial NOS (eNOS) proinflammatory cytokines, Erythropoietin (EPO), Phosphatase and tensin homologous protein of chromosome 10 gene (PTEN) signaling, NF-κB/About:
This article is published in Brain Research.The article was published on 2021-03-02. It has received 25 citations till now. The article focuses on the topics: PI3K/AKT/mTOR pathway & Notch signaling pathway.read more
Citations
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Mechanistic insights and perspectives involved in neuroprotective action of quercetin
Amarjot Kaur Grewal,Thakur Gurjeet Singh,Deepak Sharma,Veerta Sharma,Manjinder Singh,Md. Habibur Rahman,Agnieszka Najda,Magdalena Walasek-Janusz,Mohamed Kamel,Ghadeer M. Albadrani,Muhammad Furqan Akhtar,Ammara Saleem,Mohamed M. Abdel-Daim +12 more
TL;DR: A review of the role of quercetin in the protection against neurodegenerative diseases (NDDs) is presented in this article, where the authors assessed the food sources and its pharmacokinetic profile, structure activity relationship and its pathophysiological role in various NDDs.
Journal ArticleDOI
Apoptotic Pathways and Alzheimer's Disease: Probing Therapeutic Potential.
Vivek Kumar Sharma,Vivek Kumar Sharma,Thakur Gurjeet Singh,Shareen Singh,Nikhil Garg,Sonia Dhiman +5 more
TL;DR: A review of diverse and versatile apoptotic mechanisms that are indispensable for neuronal survival and constitute an integral part of the pathological progression of Alzheimer's disease can be found in this paper, where the authors identify potential targets (restoring apoptotic and antiapoptotic balance, caspases, TRADD, RIPK1, FADD, TNFα, etc.) to decide the fate of neurons and to develop potential therapeutics for treatment of AD.
Journal ArticleDOI
Pharmacological Modulation of Ubiquitin-Proteasome Pathways in Oncogenic Signaling.
Anmol Sharma,Heena Khan,Thakur Gurjeet Singh,Amarjot Kaur Grewal,Agnieszka Najda,Małgorzata Kawecka-Radomska,Mohamed Kamel,Ahmed E. Altyar,Mohamed M. del-Daim +8 more
TL;DR: A systematic literature review of PubMed, Medline, Bentham, Scopus, and EMBASE (Elsevier) databases was carried out to understand the nature of the extensive work done on modulation of ubiquitin-proteasome pathways in oncogenic signaling as discussed by the authors.
Journal ArticleDOI
Therapeutic implications of cyclooxygenase (COX) inhibitors in ischemic injury
TL;DR: This review will discuss the various COX types, specifically COX-1 andCOX-2, which are involved in developing I/R injury in organs such as the brain, spinal cord, heart, kidney, liver, and intestine.
Journal ArticleDOI
Neuropeptides: Potential neuroprotective agents in ischemic injury.
TL;DR: In this paper, the role of neuropeptides in ischemic injury has been discussed, including anti-apoptotic, anti-inflammatory, and antioxidant actions that provide a powerful protective impact in neurons when combined.
References
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Journal ArticleDOI
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism
TL;DR: In light of the recent advances in understanding of the function of PI3Ks in the pathogenesis of diabetes and cancer, the exciting therapeutic opportunities for targeting this pathway to treat these diseases are discussed.
Journal ArticleDOI
Correction: Corrigendum: The Serum Profile of Hypercytokinemia Factors Identified in H7N9-Infected Patients can Predict Fatal Outcomes
Jing Guo,Fengming Huang,Jun Liu,Yu Chen,Wei Wang,Bin Cao,Zhen Zou,Song Liu,Jingcao Pan,Changjun Bao,Mei Zeng,Haixia Xiao,Hainv Gao,Shigui Yang,Yan Zhao,Qiang Liu,Huandi Zhou,Jingdong Zhu,Xiaoli Liu,Weifeng Liang,Yida Yang,Shufa Zheng,Jiezuan Yang,Hongyan Diao,Kunkai Su,Li Shao,Hongcui Cao,Ying Wu,Min Zhao,Shuguang Tan,Hui Li,Xiaoqing Xu,Chunmei Wang,Jianmin Zhang,Li Wang,Jianwei Wang,Jun Xu,Dangsheng Li,Nanshan Zhong,Xuetao Cao,George F. Gao,Lanjuan Li,Chengyu Jiang +42 more
TL;DR: This Article contains typographical errors in Table 2 where ‘Week 2 (N = 32)’ was incorrectly given as ‘week (n’=2’.
Journal ArticleDOI
PI3K: Downstream AKTion Blocks Apoptosis
TL;DR: Results from Evan and colleagues demonstrated that mutants of V12 Ras that selectively stimulate PI3K and Akt/PKB but not the Raf/MEK/MAPK pathway are able to prevent c-myc-induced cell death in Rat-1 cells and granule neurons.
Journal ArticleDOI
The emerging mechanisms of isoform-specific PI3K signalling
TL;DR: A better understanding of how the different PI3K isoforms are regulated and control signalling could uncover their roles in pathology and reveal in which disease contexts their blockade could be most beneficial.
Journal ArticleDOI
Transcriptional Regulation by Nrf2
TL;DR: The different modes of regulation of Nrf2 activity are reviewed and the current knowledge of NRF2-mediated transcriptional control is reviewed to provide insight into mechanisms of disease and instruct new treatment strategies.