TPX2 Enhanced the Activation of the HGF/ETS-1 Pathway and Increased the Invasion of Endocrine-Independent Prostate Carcinoma Cells
Qinghong Zhou,Mingsheng Liu,Tao Shao,Pingbo Xie,Shaojie Zhu,Wei Wang,Qiong Miao,Jiaxi Peng,Peng Zhang +8 more
TLDR
In this article, a microtubulin interacted protein (TPX2) was identified as a coactivator of ETS-1, a transcription factor that plays a central role in mediating the metastasis of human malignancies.Abstract:
The prognosis for endocrine-independent prostate carcinoma is still poor due to its highly metastatic feature. In the present work, TPX2 (the targeting protein for Xklp2), which is known as a micro-tubulin interacted protein, was identified as a novel coactivator of ETS-1, a transcription factor that plays a central role in mediating the metastasis of human malignancies. TPX2 enhanced the transcription factor activation of ETS-1 and increased the expression of ETS-1's downstream metastasis-related genes, such as mmp3 or mmp9, induced by HGF (hepatocyte growth factor), a typical agonist of the HGF/c-MET/ETS-1 pathway. The protein-interaction between TPX2 and ETS-1 was examined using immunoprecipitation (IP). TPX2 enhanced the accumulation of ETS-1 in the nuclear and the recruitment of its binding element (EST binding site, EBS) located in the promoter region of its downstream gene, mmp9. Moreover, TPX2 enhanced the in vitro or in vivo invasion of a typical endocrine-independent prostate carcinoma cell line, PC-3. Therefore, TPX2 enhanced the activation of the HGF/ETS-1 pathway to enhance the invasion of endocrine-independent prostate carcinoma cells and thus it would be a promising target for prostate carcinoma treatment.read more
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Hypermethylation of the Promoter of miR-338-5p Mediates Aberrant Expression of ETS-1 and Is Correlated With Disease Severity Of Astrocytoma Patients.
TL;DR: In this article, the authors examined the correlation of the aberrant expression of ETS-1 with histological or clinical classification of astrocytoma: grade I (pilocytic, grade II (diffuse), grade III (anaplastic) and grade IV (glioblastoma multiforme).
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Target Protein for Xklp2 Functions as Coactivator of Androgen Receptor and Promotes the Proliferation of Prostate Carcinoma Cells
TL;DR: The present study indicated that TPX2 may be an activator of AR and thus exhibits potential as a novel target for prostate carcinoma treatment.
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Gleason Score-related MT1L as biomarker for prognosis in prostate adenocarcinoma and contribute to tumor progression in vitro
Lei Liu,Yaping Li,Shiying Tang,Bingmei Yang,Qiming Zhang,Ruotao Xiao,Xiaofei Hou,Cheng Liu,Lulin Ma +8 more
TL;DR: In this paper , the clinical significance and function of Gleason-score-related genes in prostate adenocarcinoma (PRAD) were derived to determine clinical significance of genes in PRAD.
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MTBP enhances the activation of transcription factor ETS-1 and promotes the proliferation of hepatocellular carcinoma cells
Hongbo Wang,Fang Chu,Liao Zhijie,Qian Bi,Li Lixin,Yunlong Zhuang,Zhang Xiaofeng,Xiao-Li Niu,Dali Zhang,He Xi,Bo'an Li +10 more
TL;DR: The results demonstrate that MTBP could function as a co-activator of transcription factor E26 transformation-specific sequence (ETS-1), which plays an important role in HCC cell proliferation and/or metastasis and promotes proliferation of HCC cells.
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Comprehensive Analysis of the Oncogenic Role of Targeting Protein for Xklp2 (TPX2) in Human Malignancies
TL;DR: This comprehensive pan-cancer analysis shows that TPX2 is a prognostic molecular biomarker for most cancers and suggests its potential as an effective therapeutic target for the treatment of these diseases.
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