Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus.
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TLDR
In 1992, Piette and colleagues suggested that the ACR revised criteria be reevaluated in light of the above discoveries, and the presence and clinical associations or antiphospholipid antibodies in patients with SLE was suggested.Abstract:
In 1982, the Diagnostic and Therapeutic Criteria Committee of the American College of Rheumatology (ACR)published revised criteria for the classification of systemiclupus erythematosus (SLE) (1). During the ensuing decade several investigators, including Drs. Graham Hughes and Donato Alarcon-Segovia, among others, have described the presence and clinical associations or antiphospholipid antibodies in patients with SLE, as well as the occurrence of theprimary antiphospholipid syndrome (2-5). In 1992, Piette and colleagues suggested that the ACR revised criteria be reevaluated in light of the above discoveries (6).read more
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Thrombocytopenia identifies a severe familial phenotype of systemic lupus erythematosus and reveals genetic linkages at 1q22 and 11p13.
R. Hal Scofield,Gail R. Bruner,Jennifer A. Kelly,Jeff Kilpatrick,Debra Bacino,Swapan K. Nath,John B. Harley +6 more
TL;DR: Results are consistent with thrombocytopenia being a component of a severe familial form of SLE and with genes at 1q22-23 and 11p13 contributing to this severe phenotype and to the subsequent high mortality associated with thROMbocy topenia in SLE.
Journal ArticleDOI
Maternal outcome in pregnant women with lupus nephritis : a prospective multicenter study
Gabriella Moroni,Andrea Doria,Elisa Giglio,Enrico Imbasciati,Chiara Tani,Margherita Zen,Francesca Anna Letizia Strigini,Barbara Zaina,Angela Tincani,Mariele Gatto,Federica de Liso,Claudia Grossi,Pier Luigi Meroni,Gianfranca Cabiddu,Piergiorgio Messa,Pietro Ravani,Marta Mosca +16 more
TL;DR: In pregnant women with lupus nephritis adverse maternal outcomes were relatively common but proved to be reversible when promptly diagnosed and treated and the body mass index (BMI) was associated with increased risk of late flares.
Journal ArticleDOI
Intrarenal cytokine gene expression in lupus nephritis
Rebecca W.Y. Chan,Fernand Mac-Moune Lai,Edmund K. Li,Lai-Shan Tam,Kai-Ming Chow,Ka-Bik Lai,Philip Kam-Tao Li,Cheuk-Chun Szeto +7 more
TL;DR: Intraglomerular expression of certain target genes correlate with the severity of systemic as well as histological activity, whereas the tubulointerstitial expression of other target genes correlation with the degree of chronic kidney scarring.
Journal ArticleDOI
Fitness, fatigue, disease activity, and quality of life in pediatric lupus
TL;DR: Young SLE patients have lower aerobic fitness than reference norms, and the 6MW may be used as a marker of fitness, but it is preferable to determine VO(2) with a graded exercise test.
Journal ArticleDOI
Polyreactive autoantibodies in systemic lupus erythematosus have pathogenic potential
TL;DR: It is demonstrated here that IgM, DNA-reactive antibodies obtained from lupus patients that are unmutated and display polyreactivity can bind to isolated glomeruli and exhibit neurotoxic potential.
References
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Journal ArticleDOI
The 1982 revised criteria for the classification of systemic lupus erythematosus
Eng M. Tan,Alan S. Cohen,James F. Fries,Alfonse T. Masi,Dennis J. McShane,Naomi F. Rothfield,Jane G. Schaller,Norman Talal,Robert Winchester +8 more
TL;DR: The 1971 preliminary criteria for the classification of systemic lupus erythematosus (SLE) were revised and updated to incorporate new immunologic knowledge and improve disease classification and showed gains in sensitivity and specificity.
Journal ArticleDOI
Anticardiolipin antibodies: detection by radioimmunoassay and association with thrombosis in systemic lupus erythematosus
E. N. Harris,Boey Ml,C G Mackworth-Young,A. E. Gharavi,B. M. Patel,S. Loizou,Graham R. V. Hughes +6 more
TL;DR: A new solid-phase radioimmunoassay for the detection of anticardiolipin antibodies is 200-400 times more sensitive than the precipitation method used in the Venereal Disease Reference Laboratory test and appears to have predictive value for thrombosis in SLE and related disorders.
Journal ArticleDOI
Criteria for the diagnosis of lupus anticoagulants: an update. On behalf of the Subcommittee on Lupus Anticoagulant/Antiphospholipid Antibody of the Scientific and Standardisation Committee of the ISTH.
Journal ArticleDOI
The "primary" antiphospholipid syndrome: major clinical and serological features.
Ronald A. Asherson,Munther A. Khamashta,José Ordi-Ros,Ronald H. W. M. Derksen,S J Machin,Jordi Barquinero,H H Outt,E. N. Harris,M Vilardell-Torres,Graham R. V. Hughes +9 more
TL;DR: The group of patients presented appears to be closely related, but distinctly separate from SLE, with a history of deep vein thromboses and a family history of SLE or a familial clotting tendency in a minority.
Journal Article
Evaluation of the anti-cardiolipin antibody test: report of an international workshop held 4 April 1986.
TL;DR: This study shows that properly performed ELISA or SRIA assays can be used to provide an accurate, reproducible, and quantitative measure of IgG and IgM aCL concentration in serum samples.
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