Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus.
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TLDR
In 1992, Piette and colleagues suggested that the ACR revised criteria be reevaluated in light of the above discoveries, and the presence and clinical associations or antiphospholipid antibodies in patients with SLE was suggested.Abstract:
In 1982, the Diagnostic and Therapeutic Criteria Committee of the American College of Rheumatology (ACR)published revised criteria for the classification of systemiclupus erythematosus (SLE) (1). During the ensuing decade several investigators, including Drs. Graham Hughes and Donato Alarcon-Segovia, among others, have described the presence and clinical associations or antiphospholipid antibodies in patients with SLE, as well as the occurrence of theprimary antiphospholipid syndrome (2-5). In 1992, Piette and colleagues suggested that the ACR revised criteria be reevaluated in light of the above discoveries (6).read more
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Immunosuppressive therapy in lupus- and mixed connective tissue disease-associated pulmonary arterial hypertension: a retrospective analysis of twenty-three cases.
Xavier Jaïs,David Launay,David Launay,Azzedine Yaici,Jérôme Le Pavec,Colas Tcherakian,Olivier Sitbon,Gérald Simonneau,Marc Humbert +8 more
TL;DR: PAH associated with SLE or MCTD may respond to a treatment combining cyclophosphamide and glucocorticoids, and patients who could benefit from this immunosuppressive therapy could be those who have less severe disease at baseline.
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Compromised CD4+ CD25(high) regulatory T-cell function in patients with relapsing-remitting multiple sclerosis is correlated with a reduced frequency of FOXP3-positive cells and reduced FOXP3 expression at the single-cell level.
Koen Venken,Niels Hellings,Marielle Thewissen,Veerle Somers,Karen Hensen,Jean-Luc Rummens,Robert Medaer,Raymond Hupperts,Piet Stinissen +8 more
TL;DR: Analysis of forkhead box P3 at the single‐cell level in MS patients and controls suggests that Tregs accumulate in the CSF of RR‐MS patients, in an attempt to down‐regulate local inflammation in the central nervous system.
Journal ArticleDOI
Immunosuppressive Therapy in Connective Tissue Diseases-Associated Pulmonary Arterial Hypertension
TL;DR: PAH associated with SLE or MCTD might respond to a treatment combining glucocorticosteroids and cyclophosphamide, and patients with a lower baseline NYHA functional class and better baseline pulmonary hemodynamics were more likely to benefit from immunosuppressive therapy.
Journal ArticleDOI
Treatment of systemic lupus erythematosus by inhibition of T cell costimulation with anti-CD154: a randomized, double-blind, placebo-controlled trial.
TL;DR: IDEC-131 administered at doses ranging 2.5-10.0 mg/kg over 16 weeks was safe and well tolerated in patients with SLE and there were statistically significant improvements from baseline in all groups, including the placebo group.
Journal ArticleDOI
Klinefelter's syndrome (47,XXY) in male systemic lupus erythematosus patients: Support for the notion of a gene-dose effect from the X chromosome
R. Hal Scofield,R. Hal Scofield,R. Hal Scofield,Gail R. Bruner,Bahram Namjou,Robert P. Kimberly,Rosalind Ramsey-Goldman,Michelle Petri,John D. Reveille,Graciela S. Alarcón,Luis M. Vilá,Jeff Reid,Bryan Harris,Shibo Li,Jennifer A. Kelly,John B. Harley,John B. Harley +16 more
TL;DR: The frequency of Klinefelter's syndrome (47,XXY), often subclinical, is increased in men with SLE by approximately 14-fold compared with its prevalence in men without SLE, consistent with the notion that SLE susceptibility is partly explained by an X chromosome gene-dose effect.
References
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Journal ArticleDOI
The 1982 revised criteria for the classification of systemic lupus erythematosus
Eng M. Tan,Alan S. Cohen,James F. Fries,Alfonse T. Masi,Dennis J. McShane,Naomi F. Rothfield,Jane G. Schaller,Norman Talal,Robert Winchester +8 more
TL;DR: The 1971 preliminary criteria for the classification of systemic lupus erythematosus (SLE) were revised and updated to incorporate new immunologic knowledge and improve disease classification and showed gains in sensitivity and specificity.
Journal ArticleDOI
Anticardiolipin antibodies: detection by radioimmunoassay and association with thrombosis in systemic lupus erythematosus
E. N. Harris,Boey Ml,C G Mackworth-Young,A. E. Gharavi,B. M. Patel,S. Loizou,Graham R. V. Hughes +6 more
TL;DR: A new solid-phase radioimmunoassay for the detection of anticardiolipin antibodies is 200-400 times more sensitive than the precipitation method used in the Venereal Disease Reference Laboratory test and appears to have predictive value for thrombosis in SLE and related disorders.
Journal ArticleDOI
Criteria for the diagnosis of lupus anticoagulants: an update. On behalf of the Subcommittee on Lupus Anticoagulant/Antiphospholipid Antibody of the Scientific and Standardisation Committee of the ISTH.
Journal ArticleDOI
The "primary" antiphospholipid syndrome: major clinical and serological features.
Ronald A. Asherson,Munther A. Khamashta,José Ordi-Ros,Ronald H. W. M. Derksen,S J Machin,Jordi Barquinero,H H Outt,E. N. Harris,M Vilardell-Torres,Graham R. V. Hughes +9 more
TL;DR: The group of patients presented appears to be closely related, but distinctly separate from SLE, with a history of deep vein thromboses and a family history of SLE or a familial clotting tendency in a minority.
Journal Article
Evaluation of the anti-cardiolipin antibody test: report of an international workshop held 4 April 1986.
TL;DR: This study shows that properly performed ELISA or SRIA assays can be used to provide an accurate, reproducible, and quantitative measure of IgG and IgM aCL concentration in serum samples.
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