Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus.
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In 1992, Piette and colleagues suggested that the ACR revised criteria be reevaluated in light of the above discoveries, and the presence and clinical associations or antiphospholipid antibodies in patients with SLE was suggested.Abstract:
In 1982, the Diagnostic and Therapeutic Criteria Committee of the American College of Rheumatology (ACR)published revised criteria for the classification of systemiclupus erythematosus (SLE) (1). During the ensuing decade several investigators, including Drs. Graham Hughes and Donato Alarcon-Segovia, among others, have described the presence and clinical associations or antiphospholipid antibodies in patients with SLE, as well as the occurrence of theprimary antiphospholipid syndrome (2-5). In 1992, Piette and colleagues suggested that the ACR revised criteria be reevaluated in light of the above discoveries (6).read more
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Specific antinuclear antibodies are associated with clinical features in systemic lupus erythematosus
Ilse Hoffman,I Peene,Lydie Meheus,Twj Huizinga,L Cebecauer,David A. Isenberg,K De Bosschere,Frank Hulstaert,Emilie Veys,F De Keyser +9 more
TL;DR: In a large and consecutive cohort of patients with SLE, clusters of antibodies were identified and previously reported associations of antibodies with symptoms were confirmed and new associations found.
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Accelerated damage accrual among men with systemic lupus erythematosus: XLIV. Results from a multiethnic US cohort.
Rosa M. Andrade,Graciela S. Alarcón,Mónica Fernández,Mandar Apte,Luis M. Vilá,John D. Reveille +5 more
TL;DR: Poorer long-term prognosis among men with SLE appears to be decisively determined by their accelerated development of damage, particularly early in the course of the disease.
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Genetic linkage and association of Fcγ receptor IIIA (CD16A) on chromosome 1q23 with human systemic lupus erythematosus
Jeffrey C. Edberg,Carl D. Langefeld,Jianming Wu,Kathy L. Moser,Kenneth M. Kaufman,Jennifer A. Kelly,Vipin Bansal,W. Mark Brown,Jane E. Salmon,Stephen S. Rich,John B. Harley,Robert P. Kimberly +11 more
TL;DR: These data are the first to demonstrate linkage and both family-based and case-control-based association of FcgammaRIIIA with SLE and provide genetic evidence supporting a role for the physiologically relevant single nucleotide polymorphism of the FcGammaR IIIA gene in the pathophysiology of this complex genetic disease.
Journal ArticleDOI
Photosensitivity and type I IFN responses in cutaneous lupus are driven by epidermal-derived interferon kappa.
Mrinal K. Sarkar,Grace A. Hile,Lam C. Tsoi,Xianying Xing,Jianhua Liu,Yun Liang,Celine C. Berthier,William R. Swindell,Matthew Patrick,Shuai Shao,Pei-Suen Tsou,Ranjitha Uppala,Maria A. Beamer,Anshika Srivastava,Stephanie L. Bielas,Paul W. Harms,Spiro Getsios,James T. Elder,John J. Voorhees,Johann E. Gudjonsson,J. Michelle Kahlenberg +20 more
TL;DR: IFN-κ is identified as a critical IFN in CLE pathology via promotion of enhanced IFN responses and photosensitivity and is a potential novel target for UVB prophylaxis and CLE-directed therapy.
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Rituximab in severe lupus nephritis: early B-cell depletion affects long-term renal outcome.
Catherine Melander,Marion Sallée,Pierre Trolliet,Sophie Candon,Xavier Belenfant,Eric Daugas,Phillipe Rémy,Virginie Zarrouk,Evangeline Pillebout,Christian Jacquot,Jean-Jacques Boffa,Alexandre Karras,Virginie Masse,Philippe Lesavre,Caroline Elie,Isabelle Brocheriou,Bertrand Knebelmann,Laure-Hélène Noël,Fadi Fakhouri +18 more
TL;DR: Rituximab is an interesting therapeutic option in relapsing or refractory lupus nephritis when early B cell depletion is obtained and negatively correlated with black ethnicity and hypoalbuminemia.
References
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Journal ArticleDOI
The 1982 revised criteria for the classification of systemic lupus erythematosus
Eng M. Tan,Alan S. Cohen,James F. Fries,Alfonse T. Masi,Dennis J. McShane,Naomi F. Rothfield,Jane G. Schaller,Norman Talal,Robert Winchester +8 more
TL;DR: The 1971 preliminary criteria for the classification of systemic lupus erythematosus (SLE) were revised and updated to incorporate new immunologic knowledge and improve disease classification and showed gains in sensitivity and specificity.
Journal ArticleDOI
Anticardiolipin antibodies: detection by radioimmunoassay and association with thrombosis in systemic lupus erythematosus
E. N. Harris,Boey Ml,C G Mackworth-Young,A. E. Gharavi,B. M. Patel,S. Loizou,Graham R. V. Hughes +6 more
TL;DR: A new solid-phase radioimmunoassay for the detection of anticardiolipin antibodies is 200-400 times more sensitive than the precipitation method used in the Venereal Disease Reference Laboratory test and appears to have predictive value for thrombosis in SLE and related disorders.
Journal ArticleDOI
Criteria for the diagnosis of lupus anticoagulants: an update. On behalf of the Subcommittee on Lupus Anticoagulant/Antiphospholipid Antibody of the Scientific and Standardisation Committee of the ISTH.
Journal ArticleDOI
The "primary" antiphospholipid syndrome: major clinical and serological features.
Ronald A. Asherson,Munther A. Khamashta,José Ordi-Ros,Ronald H. W. M. Derksen,S J Machin,Jordi Barquinero,H H Outt,E. N. Harris,M Vilardell-Torres,Graham R. V. Hughes +9 more
TL;DR: The group of patients presented appears to be closely related, but distinctly separate from SLE, with a history of deep vein thromboses and a family history of SLE or a familial clotting tendency in a minority.
Journal Article
Evaluation of the anti-cardiolipin antibody test: report of an international workshop held 4 April 1986.
TL;DR: This study shows that properly performed ELISA or SRIA assays can be used to provide an accurate, reproducible, and quantitative measure of IgG and IgM aCL concentration in serum samples.
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