Utilization of sialic acid as a coreceptor enhances reovirus attachment by multistep adhesion strengthening.
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TLDR
Results indicate that reovirus binding to sialic acid enhances virus infection through adhesion of virus to the cell surface where access to a proteinaceous receptor is thermodynamically favored.About:
This article is published in Journal of Biological Chemistry.The article was published on 2001-01-19 and is currently open access. It has received 210 citations till now. The article focuses on the topics: Sialic acid binding & N-Acetylneuraminic acid.read more
Citations
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Chemical Diversity in the Sialic Acids and Related α-Keto Acids: An Evolutionary Perspective
Takashi Angata,Ajit Varki +1 more
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Junction Adhesion Molecule Is a Receptor for Reovirus
Erik S. Barton,J. Craig Forrest,Jodi L. Connolly,James D. Chappell,Yuan Liu,Frederick J. Schnell,Asma Nusrat,Charles A. Parkos,Terence S. Dermody +8 more
TL;DR: Reovirus interaction with cell-surface receptors is a critical determinant of both cell-type specific tropism and virus-induced intracellular signaling events that culminate in cell death.
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Survey of the year 2003 commercial optical biosensor literature
Rebecca L. Rich,David G. Myszka +1 more
TL;DR: In this overview, 13 papers that should be on everyone's ‘must read’ list for 2003 are spotlighted and examples of how to identify and interpret high‐quality biosensor data are provided.
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Antiviral immunity via RIG-I-mediated recognition of RNA bearing 5′-diphosphates
Delphine Goubau,Martin Schlee,Safia Deddouche,Andrea J. Pruijssers,Thomas Zillinger,Marion Goldeck,Christine Schuberth,Annemarthe G. van der Veen,Tsutomu Fujimura,Jan Rehwinkel,Jason A. Iskarpatyoti,Winfried Barchet,Janos Ludwig,Terence S. Dermody,Gunther Hartmann,Caetano Reis e Sousa +15 more
TL;DR: It is shown that RIG-I also mediates antiviral responses to RNAs bearing 5′-diphosphates (5′pp), indicating that recognition of 5′pp-RNA acts as a powerful means of self/non-self discrimination by the innate immune system.
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Reovirus infection triggers inflammatory responses to dietary antigens and development of celiac disease
Romain Bouziat,Reinhard Hinterleitner,Judy J. Brown,Jennifer E. Stencel-Baerenwald,Mine R. Ikizler,Toufic Mayassi,Marlies Meisel,Sangman M. Kim,Valentina Discepolo,Valentina Discepolo,Andrea J. Pruijssers,Jordan D. Ernest,Jason A. Iskarpatyoti,Léa M.M. Costes,Léa M.M. Costes,Ian Lawrence,Brad A. Palanski,Mukund Varma,Matthew A. Zurenski,Solomiia Khomandiak,Nicole McAllister,Pavithra Aravamudhan,Karl W. Boehme,Fengling Hu,Janneke N. Samsom,Hans Christian Reinecker,Sonia S. Kupfer,Stefano Guandalini,Carol E. Semrad,Valérie Abadie,Chaitan Khosla,Luis B. Barreiro,Ramnik J. Xavier,Aylwin Ng,Terence S. Dermody,Bana Jabri +35 more
TL;DR: A viral infection model that makes use of two reovirus strains that infect the intestine but differ in their immunopathological outcomes discovered that it can nonetheless disrupt intestinal immune homeostasis at inductive and effector sites of oral tolerance by suppressing peripheral regulatory T cell (pTreg) conversion and promoting TH1 immunity to dietary antigen.
References
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The Attractions of Proteins for Small Molecules and Ions
TL;DR: The number and variety of known compounrjs between proteins and small molecules are increasing rapidly and make a fascinating story as discussed by the authors, and there are many compounds of serum albumin, which was used during the war by many chemists, most of whom found at least one 6ew compound.
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HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5.
Tatjana Dragic,Virginia M. Litwin,Graham P. Allaway,Scott R. Martin,Yaoxing Huang,Kirsten A. Nagashima,Charmagne Cayanan,Paul J. Maddon,Richard A. Koup,John P. Moore,William A. Paxton +10 more
TL;DR: The β-chemokine receptor CC-CKR-5 as mentioned in this paper is a second receptor for NSI primary viruses, which allows env-mediated cell-cell membrane fusion, but it does not allow the fusion of cells from some HIV-1-exposed uninfected individuals.
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CHEMOKINE RECEPTORS AS HIV-1 CORECEPTORS: Roles in Viral Entry, Tropism, and Disease
TL;DR: In this paper, the chemokine receptors CXCR4 and CCR5, members of the G protein-coupled receptor superfamily, have been identified as the principal coreceptors for T cell line-tropic and macrophagetropic HIV-1 isolates, respectively.
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Leukocytes roll on a selectin at physiologic flow rates: Distinction from and prerequisite for adhesion through integrins
TL;DR: Rolling of leukocytes on vascular endothelial cells, an early event in inflammation, can be reproduced in vitro on artificial lipid bilayers containing purified CD62, a selectin also named PADGEM and GMP-140 that is inducible on endothelial Cells.
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CD4-induced interaction of primary HIV-1 gp120 glycoproteins with the chemokine receptor CCR-5
Lijun Wu,Norma P. Gerard,Richard T. Wyatt,Hyeryun Choe,Cristina Parolin,Nancy Ruffing,Alessândra Borsetti,Angelo A. Cardoso,Elizabeth Desjardin,Walter Newman,Craig Gerard,Joseph Sodroski +11 more
TL;DR: It is suggested that HIV-1 attachment to CD4 creates a high-affinity binding site for CCR-5, leading to membrane fusion and virus entry.