Book ChapterDOI
UV-Induced Molecular Signaling Differences in Melanoma and Non-melanoma Skin Cancer.
Reads0
Chats0
TLDR
One shared characteristic of skin cancer is that, according to the current views, they all are caused by solar or artificial ultraviolet radiation (UVR).Abstract:
There are three major types of skin cancer: melanoma, basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). BCC and SCC are often referred to as non-melanoma skin cancer (NMSC). NMSCs are relatively non-lethal and curable by surgery, hence are not reportable in most cancer registries all over the world. Melanoma is the deadliest skin cancer. Its incidence rate (case number) is about 1/10th of that for NMSC, yet its death toll is ~8 fold higher than NMSC.read more
Citations
More filters
Journal ArticleDOI
Emerging Perspective: Role of Increased ROS and Redox Imbalance in Skin Carcinogenesis
TL;DR: In spite of ROS inducing skin carcinogenesis, toxic-dose ROS could trigger cell death/apoptosis and, therefore, may be an efficient therapeutic tool to battle skin cancer.
Journal ArticleDOI
Cellular Senescence and the Senescence-Associated Secretory Phenotype as Drivers of Skin Photoaging.
TL;DR: The mechanisms contributing to the accumulation of senescent cells in the skin are described and how the persistence of cellular senescence can promote impaired regenerative capacity, chronic inflammation, and tumorigenesis associated with photoaging are described.
Journal ArticleDOI
Cannabinoids in the Pathophysiology of Skin Inflammation.
Cristian Scheau,Ioana Anca Badarau,Livia-Gratiela Mihai,Andreea-Elena Scheau,Daniel Octavian Costache,Carolina Constantin,Daniela Calina,Constantin Caruntu,Raluca Simona Costache,Ana Caruntu +9 more
TL;DR: In vivo and in vitro studies that employed either phyto-, endo-, or synthetic cannabinoids were considered and the potential role of cannabinoids as antitumoral drugs is explored in relation to the inflammatory component of skin cancer.
Melanoma genome sequencing reveals frequent PREX2 mutations
Eric S. Lander,Michael F. Berger,Eran Hodis,Timothy P. Heffernan,Yonathan Lissanu Deribe,Michael S. Lawrence,Alexei Protopopov,Elena Ivanova,Ian R. Watson,Elizabeth Nickerson,Papia Ghosh,Hailei Zhang,Rhamy Zeid,Xiaojia Ren,Kristian Cibulskis,Andrey Sivachenko,Nikhil Wagle,Antje Sucker,Carrie Sougnez,Robert C. Onofrio +19 more
TL;DR: A wide range of point mutation rates was observed: lowest in melanomas whose primaries arose on non-ultraviolet-exposed hairless skin of the extremities (3 and 14 per megabase (Mb) of genome, intermediate in those originating from hair-bearing skin on the trunk (5-55 per Mb), and highest in a patient with a documented history of chronic sun exposure (111 per Mb) as mentioned in this paper.
Journal ArticleDOI
Photoprotection according to skin phototype and dermatoses: practical recommendations from an expert panel.
Thierry Passeron,Henry W. Lim,C. L. Goh,Kang Hy,F Ly,Akimichi Morita,J Ocampo Candiani,S. Puig,Sergio Schalka,L Wei,Brigitte Dréno,Jean Krutmann +11 more
TL;DR: A selective literature search was performed by an international expert panel, focusing on the type of sunscreen to recommend for photoaging, skin cancers, photodermatoses, pigmentary disorders and skin inflammatory disorders as discussed by the authors.
References
More filters
Journal ArticleDOI
Mutations of the BRAF gene in human cancer
Helen Davies,Graham R. Bignell,Charles Cox,Philip J. Stephens,Sarah Edkins,S. M. Clegg,Jon W. Teague,Hayley Woffendin,Mathew J. Garnett,William Bottomley,Neil Davis,Ed Dicks,Rebecca Ewing,Yvonne Floyd,Kristian Gray,S. Hall,Rachel Hawes,Jaime Hughes,Vivian Kosmidou,Andrew Menzies,Catherine Mould,Adrian Parker,Claire Stevens,Stephen Watt,Steven Hooper,Rebecca Wilson,Hiran Jayatilake,Barry A. Gusterson,Colin Cooper,Janet Shipley,Darren Hargrave,Kathy Pritchard-Jones,Norman J. Maitland,Georgia Chenevix-Trench,Gregory J. Riggins,Darell D. Bigner,Giuseppe Palmieri,Antonio Cossu,Adrienne M. Flanagan,Andrew G. Nicholson,Judy W. C. Ho,Suet Yi Leung,Siu Tsan Yuen,Barbara L. Weber,Hilliard F. Seigler,Timothy L. Darrow,Hugh Paterson,Richard Marais,Christopher J. Marshall,Richard Wooster,Michael R. Stratton,P. Andrew Futreal +51 more
TL;DR: BRAF somatic missense mutations in 66% of malignant melanomas and at lower frequency in a wide range of human cancers, with a single substitution (V599E) accounting for 80%.
Journal ArticleDOI
Signatures of mutational processes in human cancer
Ludmil B. Alexandrov,Serena Nik-Zainal,Serena Nik-Zainal,David C. Wedge,Samuel Aparicio,Sam Behjati,Sam Behjati,Andrew V. Biankin,Graham R. Bignell,Niccolo Bolli,Niccolo Bolli,Åke Borg,Anne Lise Børresen-Dale,Anne Lise Børresen-Dale,Sandrine Boyault,Birgit Burkhardt,Adam Butler,Carlos Caldas,Helen Davies,Christine Desmedt,Roland Eils,Jorunn E. Eyfjord,John A. Foekens,Mel Greaves,Fumie Hosoda,Barbara Hutter,Tomislav Ilicic,Sandrine Imbeaud,Sandrine Imbeaud,Marcin Imielinsk,Natalie Jäger,David T. W. Jones,David T. Jones,Stian Knappskog,Stian Knappskog,Marcel Kool,Sunil R. Lakhani,Carlos López-Otín,Sancha Martin,Nikhil C. Munshi,Nikhil C. Munshi,Hiromi Nakamura,Paul A. Northcott,Marina Pajic,Elli Papaemmanuil,Angelo Paradiso,John V. Pearson,Xose S. Puente,Keiran Raine,Manasa Ramakrishna,Andrea L. Richardson,Andrea L. Richardson,Julia Richter,Philip Rosenstiel,Matthias Schlesner,Ton N. Schumacher,Paul N. Span,Jon W. Teague,Yasushi Totoki,Andrew Tutt,Rafael Valdés-Mas,Marit M. van Buuren,Laura van ’t Veer,Anne Vincent-Salomon,Nicola Waddell,Lucy R. Yates,Icgc PedBrain,Jessica Zucman-Rossi,Jessica Zucman-Rossi,P. Andrew Futreal,Ultan McDermott,Peter Lichter,Matthew Meyerson,Matthew Meyerson,Sean M. Grimmond,Reiner Siebert,Elias Campo,Tatsuhiro Shibata,Stefan M. Pfister,Stefan M. Pfister,Peter J. Campbell,Peter J. Campbell,Peter J. Campbell,Michael R. Stratton,Michael R. Stratton +84 more
TL;DR: It is shown that hypermutation localized to small genomic regions, ‘kataegis’, is found in many cancer types, and this results reveal the diversity of mutational processes underlying the development of cancer.
Journal ArticleDOI
Distinct Sets of Genetic Alterations in Melanoma
John A. Curtin,Jane Fridlyand,Toshiro Kageshita,Hetal N. Patel,Klaus J. Busam,Heinz Kutzner,Kwang Hyun Cho,Setsuya Aiba,Eva B. Bröcker,Philip E. LeBoit,Daniel Pinkel,Boris C. Bastian +11 more
TL;DR: The genetic alterations identified in melanoma at different sites and with different levels of sun exposure indicate that there are distinct genetic pathways in the development of melanoma and implicate CDK4 and CCND1 as independent oncogenes in melanomas without mutations in BRAF or N-RAS.
Journal ArticleDOI
A landscape of driver mutations in melanoma
Eran Hodis,Ian R. Watson,Ian R. Watson,Gregory V. Kryukov,Gregory V. Kryukov,Gregory V. Kryukov,Stefan T. Arold,Marcin Imielinski,Jean Philippe Theurillat,Elizabeth Nickerson,Daniel Auclair,Liren Li,Liren Li,Chelsea S. Place,Daniel DiCara,Alex H. Ramos,Alex H. Ramos,Michael S. Lawrence,Kristian Cibulskis,Andrey Sivachenko,Douglas Voet,Gordon Saksena,Nicolas Stransky,Robert C. Onofrio,Wendy Winckler,Kristin G. Ardlie,Nikhil Wagle,Nikhil Wagle,Jennifer A. Wargo,Kelly Chong,Donald L. Morton,Katherine Stemke-Hale,Guo Chen,Michael S. Noble,Matthew Meyerson,John E. Ladbury,Michael A. Davies,Jeffrey E. Gershenwald,Stephan N. Wagner,Dave S.B. Hoon,Dirk Schadendorf,Eric S. Lander,Eric S. Lander,Stacey Gabriel,Gad Getz,Levi A. Garraway,Lynda Chin +46 more
TL;DR: The spectrum of driver mutations provided unequivocal genomic evidence for a direct mutagenic role of UV light in melanoma pathogenesis, providing oncogenic insights in BRAF- and NRAS-driven melanoma as well as those without known NRAS/BRAF mutations.
Journal ArticleDOI
8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G----T and A----C substitutions.
TL;DR: These assays illustrate mutagenic replication of oh8Gua as template causing G----T substitutions and misincorporation of Oh8G Hua as substrate causing A----C substitutions, both caused by oh8 Gua.