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What’s normal? Oligosaccharide concentrations and profiles in milk produced by healthy women vary geographically

TLDR
The hypothesis that normal HMO concentrations and profiles vary geographically, even in healthy women is supported and targeted genomic analyses are required to determine whether these differences are due at least in part to genetic variation.
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This article is published in The American Journal of Clinical Nutrition.The article was published on 2017-05-01 and is currently open access. It has received 263 citations till now. The article focuses on the topics: Postpartum period.

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Explorations in a galaxy of sialic acids: a review of sensing horizons, motivated by emerging biomedical and nutritional relevance

TL;DR: In this paper , the authors present a rationale for nutrition value and biodiagnostic requirements of sialic acids including Neu5Ac and Neu4Ac. Â
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Interactions between human milk oligosaccharides, microbiota and immune factors in milk of women with and without mastitis

TL;DR: In this paper , a comparison between subacute (SAM) and acute (AM) mastitis cases revealed differences related to the etiological agent (S. epidermidis in SAM; Staphylococcus aureus in AM), milk immunological profile (high content of IL10 and IL13 in SAM and IL2 in AM) and milk HMOs profile, which indicated that microbiological, immunological and HMO profiles of milk are related to mammary health of women.
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Six Oligosaccharides' Variation in Breast Milk: A Study in South China from 0 to 400 Days Postpartum.

TL;DR: Wang et al. as mentioned in this paper investigated the variation in oligosaccharide levels in the breast milk of south Chinese mothers in a prolonged breastfeeding period of up to 400 days postpartum.
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Maternal Diet Is Associated with Human Milk Oligosaccharide Profile

TL;DR: In this paper , a cross-sectional study of the MAMI cohort with 101 human milk samples from healthy mothers was conducted to examine the association between maternal diet and HMO profiles.
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Extraction and Quantitative Analysis of Goat Milk Oligosaccharides: Composition, Variation, Associations, and 2'-FL Variability.

TL;DR: The composition of goat MOS (gMOS) from colostrum up to the 9th month of lactation was studied to conceive an overview of the structures present and their fate, suggesting the possibility of a secretor/non-secretor goat genotype, similar to humans.
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Journal Article

R: A language and environment for statistical computing.

R Core Team
- 01 Jan 2014 - 
TL;DR: Copyright (©) 1999–2012 R Foundation for Statistical Computing; permission is granted to make and distribute verbatim copies of this manual provided the copyright notice and permission notice are preserved on all copies.
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Controlling the false discovery rate: a practical and powerful approach to multiple testing

TL;DR: In this paper, a different approach to problems of multiple significance testing is presented, which calls for controlling the expected proportion of falsely rejected hypotheses -the false discovery rate, which is equivalent to the FWER when all hypotheses are true but is smaller otherwise.
Book

ggplot2: Elegant Graphics for Data Analysis

TL;DR: This book describes ggplot2, a new data visualization package for R that uses the insights from Leland Wilkisons Grammar of Graphics to create a powerful and flexible system for creating data graphics.
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Metagenes and molecular pattern discovery using matrix factorization.

TL;DR: Nonnegative matrix factorization is described, an algorithm based on decomposition by parts that can reduce the dimension of expression data from thousands of genes to a handful of metagenes, and found less sensitive to a priori selection of genes or initial conditions and able to detect alternative or context-dependent patterns of gene expression in complex biological systems.
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