What’s normal? Oligosaccharide concentrations and profiles in milk produced by healthy women vary geographically
Michelle K. McGuire,Courtney L. Meehan,Mark A. McGuire,Janet E. Williams,James A. Foster,Daniel W. Sellen,Elizabeth W. Kamau-Mbuthia,Egidioh W. Kamundia,Samwel Mbugua,Sophie E. Moore,Andrew M. Prentice,Linda J. Kvist,Gloria E. Otoo,Sarah L Brooker,William J. Price,Bahman Shafii,Caitlyn D. Placek,Kimberly A. Lackey,Bianca Robertson,Susana Manzano,Lorena Ruiz,Juan M. Rodríguez,Rossina G. Pareja,Lars Bode +23 more
TLDR
The hypothesis that normal HMO concentrations and profiles vary geographically, even in healthy women is supported and targeted genomic analyses are required to determine whether these differences are due at least in part to genetic variation.About:
This article is published in The American Journal of Clinical Nutrition.The article was published on 2017-05-01 and is currently open access. It has received 263 citations till now. The article focuses on the topics: Postpartum period.read more
Citations
More filters
Journal ArticleDOI
Variations in the Composition of Human Milk Oligosaccharides Correlates with Effects on Both the Intestinal Epithelial Barrier and Host Inflammation: A Pilot Study
Richard Y. Wu,Steven R. Botts,Kathene C. Johnson-Henry,Eva Landberg,Thomas Abrahamsson,Philip M. Sherman +5 more
TL;DR: Evidence is provided of both shared and distinct effects on the host intestinal epithelial function that are attributable to inter-individual differences in the composition of human milk oligosaccharides.
Journal ArticleDOI
Human milk oligosaccharides alleviate stress-induced visceral hypersensitivity and associated microbiota dysbiosis
TL;DR: In this paper , the authors investigated whether human milk oligosaccharides (HMOs) impact visceral hypersensitivity (VHS) and explored the role of the gut microbiota in alleviating abdominal pain.
Journal ArticleDOI
Studies and Application of Sialylated Milk Components on Regulating Neonatal Gut Microbiota and Health.
Yushuang Wang,Xiaolei Ze,Binqi Rui,Xinke Li,Nina Zeng,Jieli Yuan,Wenzhe Li,Jingyu Yan,Ming Li +8 more
TL;DR: In this article, the authors reviewed the current research progress in the regulation of sialylated milk oligosaccharides and glycoconjugates on neonatal gut microbiota and health.
Journal ArticleDOI
Environmental determinants of human milk composition in relation to health outcomes
Zoya Gridneva,Alexandra D George,Majed A Suwaydi,Azhar S M Sindi,Jie Ma,Lisa F Stinson,Donna T. Geddes +6 more
TL;DR: Current literature shows lactation is a dynamic process and is responsive to multiple environmental challenges including geographical location, lifestyle, persistent pollutants and maternal factors that may influence human milk composition in a synergistic manner and should be considered in order to improve infant and maternal outcomes on a populations scale.
Journal ArticleDOI
A human milk oligosaccharide, 2′-fucosyllactose, enhances the immunity in mice fed an infant formula milk diet
TL;DR: The immune effect of 2′-fucosyllactose in mice fed an infant formula (IF) milk diet was studied and there was a significant increase in thymus index in high dose 2′FL group.
References
More filters
Journal Article
R: A language and environment for statistical computing.
TL;DR: Copyright (©) 1999–2012 R Foundation for Statistical Computing; permission is granted to make and distribute verbatim copies of this manual provided the copyright notice and permission notice are preserved on all copies.
Journal ArticleDOI
Controlling the false discovery rate: a practical and powerful approach to multiple testing
Yoav Benjamini,Yosef Hochberg +1 more
TL;DR: In this paper, a different approach to problems of multiple significance testing is presented, which calls for controlling the expected proportion of falsely rejected hypotheses -the false discovery rate, which is equivalent to the FWER when all hypotheses are true but is smaller otherwise.
Book
ggplot2: Elegant Graphics for Data Analysis
TL;DR: This book describes ggplot2, a new data visualization package for R that uses the insights from Leland Wilkisons Grammar of Graphics to create a powerful and flexible system for creating data graphics.
gplots: Various R Programming Tools for Plotting Data
Gregory R. Warnes,Ben Bolker,L. Bonebakker,Robert Gentleman,Wha Liaw,T. Lumley,M Maechler,A. Magnusson,S. Moeller,Michael L. Schwartz,B Venables,Wolfgang Huber,Andy Liaw,R. Gregory,BB Warnes,Lodewijk Bonebakker,Robert Gentleman,Wolfgang Huber Andy Liaw,Thomas Lumley,Martin Maechler,Arni Magnusson,Steffen Moeller,Marc Schwartz,Bill Venables +23 more
Journal ArticleDOI
Metagenes and molecular pattern discovery using matrix factorization.
TL;DR: Nonnegative matrix factorization is described, an algorithm based on decomposition by parts that can reduce the dimension of expression data from thousands of genes to a handful of metagenes, and found less sensitive to a priori selection of genes or initial conditions and able to detect alternative or context-dependent patterns of gene expression in complex biological systems.